by Jennifer Marchbank  , KJ Reed  , Claire Robson  , Gloria Gutman  and Balbir Gurm

Received: 04 January 2024;  Published: 18 March 2024;  doi: 10.21926/obm.geriatr.2401274

Elder abuse occurs to older adults who are members of gender and sexual minorities (GSM). Whilst most of that abuse is similar to that experienced by their heterosexual and cisgender peers GSM older adults face particular vulnerabilities due to their life experiences and changes. In this article we report on our findings from a literature search and knowledge synthesis, conducted as part of a larger project to inform Canadian policy makers working to eliminate gender and sexuality-based inequalities. The review inc [...]

by Sami Badwan  , Elizabeth Bailey  and James M. Harper

Received: 09 November 2022;  Published: 07 March 2023;  doi: 10.21926/obm.geriatr.2301226

In the 1950’s Denham Harman proposed the Free Radical Theory of Aging whereby species lifespan and individual longevities are the consequence of free radical driven damage to biomolecules. This led to decades of research to ascertain the effect of altered antioxidant defense systems on aging and mortality in an array of species using reverse genetics and dietary manipulation. Within invertebrates, the data generally support the Free Radical Theory in that overexpression of antioxidant enzymes or dietary supplementa [...]

by Naoaki Sakata  , Gumpei Yoshimatsu  and Shohta Kodama

Received: 15 January 2019;  Published: 03 April 2019;  doi: 10.21926/obm.transplant.1902059

Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease such as chronic pancreatitis or pancreatic injury. However, because this surgery involves removal of the whole pancreas, both exocrine and endocrine pancreatic functions are abolished, significantly impairing the nutritional statuses of patients as well as having other detrimental outcomes. Thus, especially in benign cases additional treatment to recover endocrine function is recommended, as permanent endocrine [...]

by Michael Fossel

Received: 20 March 2018;  Published: 28 March 2018;  doi: 10.21926/obm.geriatr.1801004

All of us are intuitively aware, and many of us explicitly aware as well, of the meaning of geriatrics as a specialty. After all, most of us practice geriatrics or we have been intimately involved with this area and we are know the reality of geriatrics. Or do we? Geriatrics is an oddly ill-defined specialty when you look at it more carefully. Some of us practice medicine, some of us practice in the social sciences, and many of us simply do our jobs day-to-day and try to get by. What we share, however, is the heart [...]

by Regiani Aparecida de Almeida  , Ricardo Vicente de Paula Rezende  , Flavia Aparecida Reitz Cardoso  and Lucio Cardozo Filho

Received: 17 December 2022;  Published: 18 April 2023;  doi: 10.21926/jept.2302016

In this work with CFD simulations, the evaluation of the supercritical anti-solvent (SAS) process for producing nanoparticles from an expanded solution of ethanol/solute in carbon dioxide is reported. The influence of the solution and antisolvent flow rates on mean particle size, the flow dynamic, and the supercritical mixture's jet velocity must be well established in the literature and analyzed. The high flow rate of the anti-solvent resulted in increased mean particle sizes for all studied cases. At the lowe [...]

by Clément Dumont  , Madeleine Lefèvre  , Quiterie Aussedat  , Pierre-Louis Régnier  , Alexandra Masson-Lecomte  , Evanguelos Xylinas  , Hélène Gauthier  , Virginie Fossey-Diaz  , Amélie Arégui  and Stéphane Culine

Received: 23 July 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104183

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because of their perceived frailty. Therefore, in order to evaluate the effectiveness of C-NAC in elderly patients with MIBS, we retrospectively reviewed the medical files of [...]

by Nicholas J. Geraghty  , Amal Elhage  , Peter Cuthbertson  , Debbie Watson  and Ronald Sluyter

Received: 06 June 2022;  Published: 06 September 2022;  doi: 10.21926/obm.transplant.2203166

Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy is limited by graft-versus-host disease (GVHD). This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. The immune cell receptor channel P2X7 and its ligand adenosine 5’-triphosphate (ATP) have been implicated in GVHD pathogenesis. Therefore, this signaling axis represents a potential therapeutic target. This study aime [...]

by Vardan Apinyan

Received: 30 March 2023;  Published: 24 June 2023;  doi: 10.21926/rpm.2302026

This paper considers a finite-sized two-leg ladder of spin-1/2 particles with local inter-chain Ising interaction. We include the effects of an external magnetic field by incorporating a Zeeman-type coupling between the magnetic field and the spins localized on the lattice sites. To analyze the system, we utilize the transfer-matrix formalism to calculate the partition function. We compute the magnetization for different configurations by varying the system's parameters. We observe the presence 3of spontaneous magn [...]

by Takeshi Hatta  , Taketoshi Hatta  , Junko Hatta  , Akihiko Iwahara  , Kazumi Fujiwara  , Kimiko Kato  and Yukiharu Hasegawa

Received: 15 October 2021;  Published: 24 February 2022;  doi: 10.21926/obm.geriatr.2201190

In the present study, we identified the factors of cognitive and physical performances predicting self-rated health perception (SRH) using an SRH questionnaire in 660 (298 men and 362 women) upper-middle-aged community dwellers. In addition, neuropsychological test battery and physical ability tests were applied. A multiple regression analysis was conducted using the forced entry method; digit cancellation test (D-CAT1), logical memory test, verbal fluency test, back strength, timed-up and-go (TUG), balancing test, [...]

by Annapaola Mariniello  and Silvia Novello

Received: 15 November 2018;  Published: 22 March 2019;  doi: 10.21926/obm.genet.1901069

Immune oncology treatment with immune checkpoint inhibitors (ICIs) is revolutionizing therapeutic approach for advanced non-small cell lung cancer (NSCLC) patients, in terms of longer survival and improved quality of life. To date, the widely used and approved biomarker is programmed death ligand 1 (PD-L1) expression on tumour cells, but it is considered not accurate and it is more likely that many factors, related to both cancer and host, may better predict response to ICI. Among those factors, great attention is [...]