by Carine Vassy  , Laurence Brunet  and Christine Noiville

Received: 02 September 2021;  Published: 25 February 2022;  doi: 10.21926/obm.genet.2201149

This article examines the regulation of the screening of fetal abnormalities in France before and after the implementation of the new technique of non-invasive prenatal testing (NIPT) in 2013. In addition, this article evaluates the effectiveness of the regulatory framework in addressing the ethical and social issues raised by this technique from a legal and sociological perspective. The analysis reveals that the regulations, consistent with that applied to other prenatal screening techniques, fail to take proper a [...]

by Megan Berberich  and Bettina Bernstein

Received: 10 March 2018;  Published: 13 November 2018;  doi: 10.21926/obm.icm.1804030

Background: Treatment of mood and anxiety disorders with supplements, herbs and nutraceuticals (dietary supplements) is at this point viewed as an integrative or alternative treatment, however these substances have been around for quite some time and are regarded as basic to the understanding of human biochemistry, physiology, health and illness in medicine. Methods: This review article was done using a literature search utilizing the National Library of Medicine online data base and the PCOM electronic library dat [...]

by Dimitrios Dionysopoulos  , Olga Gerasimidou  and Constantinos Papadopoulos

Received: 01 May 2022;  Published: 01 June 2022;  doi: 10.21926/rpm.2202011

Glass ionomer cements (GICs) are dental materials that were invented by Wilson & Kent in 1972. They can chemically bond to enamel and dentin and can exhibit anti-cariogenic activity that allows the release and uptake of fluoride ions. They also possess the ability to render color. The setting reaction of GICs is a neutralization reaction that results in the formation of polycarboxylate salts. The most important GIC modification process involves the addition of resin components, resulting in the development of resin [...]

by Ciro Comparetto  and Franco Borruto

Received: 31 August 2023;  Published: 13 September 2023;  doi: 10.21926/obm.geriatr.2303248

In the United States (US), menopause occurs at an average age of 52. Menopausal symptoms tend to be maximal during the few years before and the year after menopause (during perimenopause), except for symptomatic vulvovaginal atrophy, which may worsen over time. Up to 20% of bone density loss occurs during the first 5 years after menopause, followed by an age-related bone loss rate similar to that in men. Menopause should be considered confirmed if an age-appropriate woman who is not pregnant has not had a menstrual [...]

by Kuldeep Saini  , Vinay Mohan Pathak  , Arpit Tyagi  and Rani Gupta

Received: 11 June 2022;  Published: 22 September 2022;  doi: 10.21926/cr.2203029

Cyclodextrin glycosyltransferase (CGTase) is a multifunctional enzyme that hydrolyzes the α-glycosidic bond between two sugar molecules and synthesizes cyclodextrins (CDs) and other transglycosylation products. It is a ubiquitously present extracellular enzyme that offers the CGTase-producing organism the sole right onto starch substrates over other microbes. The present review provides a brief account of diversity among CGTase-producing microbes, CGTase production in different heterologous hosts (wherein ext [...]

by Dana Shamshtein  and Timur Liwinski

Received: 06 December 2021;  Published: 17 February 2022;  doi: 10.21926/rpn.2201003

Major depressive disorder (MDD) is a debilitating illness that places a great burden on global health. A ketogenic diet, which has traditionally been used for treating refractory epileptic disorders, is being increasingly explored for its potential of alleviating other neuropsychiatric conditions. Providing an up-to-date summary on the ketogenic diet’s potential to alleviate MDD, its neurobiological basis, and preliminary clinical evidence. A structured literature survey was performed, and a narrative review was wr [...]

by BAGOT Jean-Lionel

Received: 31 May 2018;  Published: 15 September 2018;  doi: 10.21926/obm.icm.1803019

Background: After fatigue, pain is one of the major complaints from cancer patients. Regular use of Class 1 analgesics may cause side effects and is not always sufficient to relieve pain. Homeopathy is the complementary and integrative medicine most frequently used in France in supportive care in oncology (SCO). What is its place in the treatment of pain? Method: Extraction and analysis of results concerning pain from three surveys, two of which were carried out in France, on the main indications of homeopathy in S [...]

by Sonica Sondhi  , Navleen Kaur Chopra  , Aditya Kumar  and Naveen Gupta

Received: 21 February 2023;  Published: 05 May 2023;  doi: 10.21926/aeer.2302030

A multicopper oxidase, laccases catalyze the four-electron reduction of the substrate with the use of molecular oxygen. Laccases are abundant in nature and can be found in virtually every form of life on the planet. Generally speaking, laccases are classified into three types: blue, white, and yellow. Plant, bacterial and fungal laccases all have the same trinuclear copper site for substrate reduction. Non-phenolic as well as phenolic molecules are both capable of being catalyzed by this enzyme. Laccases are used i [...]

by Jessica Lin  , Valentina L Kouznetsova  and Igor F Tsigelny

Received: 08 December 2020;  Published: 24 May 2021;  doi: 10.21926/obm.genet.2102131

Feline cancers have not been studied as extensively as canine cancers, though they may offer similar advantages, with cats being immunocompetent animals subject to similar conditions as their human counterparts. The most common feline cancers include lymphoma, squamous cell carcinoma, sarcoma, and mammary tumors, though mast cell tumors were also investigated in this review. As the pathogenesis of many feline cancers remains unclear, this study seeks to elucidate some molecular mechanisms behind feline cancers. Fel [...]

by Ryan Anthony  , Michael J. Macartney  and Gregory E. Peoples

Received: 12 November 2024;  Published: 19 March 2025;  doi: 10.21926/rpn.2501004

Long-chain omega-3 fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), support heart function during exercise and recovery by incorporating into the cardiac cell membranes. Traditionally sourced from fish and fish oil, algae-derived LCn-3PUFA have become alternative in supplemental forms. This study evaluated whether 12 weeks supplementation of a microencapsulated algal oil, delivered as chewable tablets, would perform equivalently to fish-derived LCn-3PUFA in boosting the [...]