by Boel De Paepe

Received: 28 February 2019;  Published: 16 May 2019;  doi: 10.21926/obm.genet.1902079

In order to successfully recover from damage, skeletal muscle tissue requires proper activation of a tightly orchestrated repair program. Non-coding RNAs actively participate in this complex process of demolition and rebuilding. In this review, the contribution of dysregulated non-coding RNA expression to disease-associated pathological changes is explored in hereditary muscular dystrophies and idiopathic inflammatory myopathies. Disturbances in spatiotemporal expression of non-coding RNAs appear to be key factors [...]

by Shih-Ang Hsu

Received: 25 July 2021;  Published: 02 September 2021;  doi: 10.21926/aeer.2103022

Spatial relation between wind stress and storm surge during two hurricanes in 2020 is investigated. It is found that, during Laura’s landfall, the area inside of 65 knots (34 m s -1) isotach or line of equal wind speed can produce up to 18 ft (5.5 m) inundation and during Delta, the area inside of 50 knots (26 m s -1) up to 11 ft (3.3 m) high water level above the ground. The tropical cyclone (TC) surface analysis near landfall by the Regional and Mesoscale Meteorology Branch (RAMMB) is recommended as a first [...]

by Farida Arisanti  , Tertianto Prabowo  , Putri Endyana  and Apichana Kovindha

Received: 03 October 2024;  Published: 18 March 2025;  doi: 10.21926/obm.neurobiol.2501279

Spinal tuberculosis (TB), an extrapulmonary manifestation of TB, primarily involves one or multiple vertebrae, with a high prevalence at the thoracolumbar region, which can compromise spinal cord integrity and result in severe sequelae such as paraplegia, bladder and bowel dysfunction, and mobility limitation. This study aimed to review medical, surgical, and rehabilitation management, clinical outcomes, and prognostic factors of spinal TB with spinal cord injury (SCI). Research was conducted utilizing databases su [...]

by Hong Chee Chew  , Ling Gao  , Jeanette E. Villaneuva  , Aoife Doyle  , Mark Hicks  , Andrew Jabbour  , Kumud K. Dhital  and Peter S. Macdonald

Received: 09 March 2019;  Published: 18 June 2019;  doi: 10.21926/obm.transplant.1902067

Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in donation after circulatory death (DCD), blood collection may delay delivery of preservation solutions resulting in longer warm ischaemic times for the heart and other organs. Banked blood (BB) is a potential alternative [...]

by Marina Moguilevitch  and Tracey Straker

Received: 05 July 2020;  Published: 12 November 2020;  doi: 10.21926/obm.transplant.2004123

Clinical presentation and progression of Wilson’s disease can be diverse in different groups of patients. While young children most likely to present with acute or chronic liver failure, older children and adults may exhibit extrahepatic manifestation like neuropsychiatric, cardiac, renal, pancreatic and several others. Diagnosis of Wilson’s disease is based on the combination of specific clinical findings, laboratory and genetic testing. There are different modalities of treatment available for this condition. Liv [...]

by Chaimae Merimi  , Abdessamad Benabbou  , Lamiae Bourassi  , Abdelhay Addous  , Ahmed A. Elhenawy  , Rachid Touzani  and Belkheir Hammouti

Received: 22 January 2025;  Published: 25 June 2025;  doi: 10.21926/obm.icm.2502027

Cardiovascular diseases and hypertension represent significant global health challenges, driving the need for innovative therapeutic solutions. In this study, we employed advanced in silico methods to investigate the molecular properties of two bioactive compounds, Flavonoids and Rosmarinic Acid, extracted from five medicinal plants: Rosemary, Oregano, Pink Savory, Lemon Balm, and Saffron. The bioactive compounds were evaluated against key biological targets associated with hypertension and cardiovascular diseases, [...]

by Omid Ranjbar Pouya  , Ahmad Byagowi  , Debbie M. Kelly  and Zahra Moussavi

Received: 20 August 2018;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902059

Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) from VR scenes has not been adequately investigated. During this study, we used a novel rotating visual scene to study the effects of aging, prior experience with VR, and dementia on the accuracy of encoding categorical [...]

by Erivaldo Genuíno Lima  , Fabiana Medeiros Nascimento Silva  , Tellys Lins Almeida Barbosa  and Meiry Gláucia Freire Rodrigues

Received: 20 December 2022;  Published: 07 April 2023;  doi: 10.21926/cr.2302015

This work prepared mordenite using seeds and without organic structure-directing agents (OSDAs). The Mo/Mordenite was prepared through wet impregnation and the catalysts’ performance was checked for transesterification of soybean oil with methanol. The mordenite zeolite was prepared through hydrothermal crystallization under static conditions with a molar composition of 6Na2O:Al2O3:30SiO2:780H2O. The catalyst samples were characterized crystallinity through X-ray diffraction, elemental composition by X-ray fluoresc [...]

by Chloe Moran  , Hannah Shaw  , Sue Black  and Kay Brewster

Received: 29 July 2022;  Published: 16 January 2023;  doi: 10.21926/obm.icm.2301006

There is increasing evidence for the effectiveness of brief, group-based compassionate mind training (CMT) in reducing shame and self-criticism, and increasing self-compassion. The current evaluation of an 8-week CMT group programme in an NHS Physical Health Psychology Service supports these findings. Based on a cross-diagnostic sample of 25-39 participants with physical health difficulties, results demonstrate significant reduction in depression and anxiety, significant increase in perceived wellbeing and acceptan [...]

by Shashya Wijesinghe  and Elizabeta B. Mukaetova-Ladinska

Received: 03 March 2024;  Published: 10 May 2024;  doi: 10.21926/obm.geriatr.2402279

In the UK, 25,000 people from ethnic minority background live with dementia. Although dementia associated risk factors are common amongst South Asians, they tend to present at services later and when in crisis. This review explores UK South Asian communities perception of dementia to understand factors impacting their decision to seek help. Search terms assisted by the PICO strategy were inputted into five databases and ten qualitative papers identified. Meta-ethnography methodological framework was implemented for [...]