by Fawzy Georges

Received: 21 April 2020;  Published: 13 August 2020;  doi: 10.21926/obm.genet.2003115

The challenges which face the world today can be summed up in a few words: An increasingly congested world with dwindling areas of viable cultivated land and accelerating climate instability. The combined effect of these realities, together with the trend of striving to extend the average human life, puts the world on the path toward future catastrophe. This situation makes it imperative to seek realistic and practical solutions, which must be able to address food shortages and climate problems in a timely manner. [...]

by Satchit Anand Saha  , Katelyn Ann Williams  , George Murphy  and Sandeep Ajoy Saha

Received: 24 September 2023;  Published: 09 January 2024;  doi: 10.21926/obm.icm.2401006

Food insecurity and insufficient access to affordable nutrition have been associated with increased risk for the development of multiple chronic medical conditions, including cardiovascular disease. In this narrative review, we explore the association between food insecurity and the development of chronic medical conditions that confer increased cardiometabolic risk, cardiovascular disease, and mortality. We also identify the various barriers leading to food insecurity and lack of food literacy, with an emphasis on [...]

by Jun Gu  , Wei Wang  , Guilin Tang  , Gokce A. Toruner  , Ming Zhao  , Steven Sfamenos  , Zhenya Tang  , Joseph D. Khoury  and L. Jeffrey Medeiros

Received: 13 October 2020;  Published: 07 December 2020;  doi: 10.21926/obm.transplant.2004128

Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). DCL might represent up to 5% of the post-HSCT disease relapses, but case numbers reported in the literature might underestimate the frequency. The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. Although many theories have been proposed for leukemogenesis of DCL, the underl [...]

by Birthe Osorio  and Karsten Münstedt

Received: 27 February 2019;  Published: 05 July 2019;  doi: 10.21926/obm.icm.1903043

Background: In particular, the women with breast cancer seek methods offered by complementary and alternative medicine (CAM). Unfortunately, the value of most of such methods remains unclear. Methods: The present review was aimed at identifying reasonable strategies for patients with breast cancer on the basis of the current literature. Results: The analyses revealed that there is no evidence of alternative medicine which might result in healing. However, several strategies are available which could improve patient [...]

by Steven R. Brenner

Received: 29 August 2018;  Published: 26 February 2019;  doi: 10.21926/obm.geriatr.1901035

Alzheimer Disease may result from excessive stimulation of the innate immune system from development of underlying opportunistic infections and impaired age related self-recognition as non-self, due to immunodeficiency and immunosenescence, resulting in excessive inflammation and runaway Beta-amyloid production (a component of the innate immune system) causing cytosolic calcium overload. Excessive cytosolic calcium may cause over activation of calcineurin and inactivation of cis-trans prolyl isomerase (Pin1), with [...]

by Martin Wynn  and Peter Jones

Received: 06 September 2023;  Published: 07 December 2023;  doi: 10.21926/aeer.2304053

While artificial intelligence has been attracting increasing investment and controversy, a new, and potentially much more powerful technology, Quantum Computing, is on the business horizon. Already, organizations are assessing its potential for addressing a range of computationally challenging issues, such as last-mile optimization and cryptanalysis to break encryption algorithms, and are exploring possible applications in a range of business areas. While the advent of Quantum Computing may bring an array of opport [...]

by Musa Itopa Yakubu  , Nuhu Mohammed Danjamu  , Mohammed Garba Magaji  , Sani Malami  , Axel Becker  , Medinat Yakubu Abbas  and Ben Ahmed Chindo

Received: 25 February 2022;  Published: 31 March 2022;  doi: 10.21926/obm.icm.2201013

Preparations of Zingiber officinale are used in Nigerian folk medicine to manage colds, pain, arthritis, nausea, and epilepsy. The ameliorative effects of co-administering aqueous Zingiber officinale extract (GE) and sodium valproate (SDV) on pentylenetetrazole-kindled mice were evaluated regarding cognitive deficits, neuronal cell loss, and seizure severity. GFAP was also quantified. Male mice were pretreated with GE (50 mg/kg), SDV (100 and 200 mg/kg), and GE + SDV before kindling. After kindling, the mice underw [...]

by Chloe Moran  , Hannah Shaw  , Sue Black  and Kay Brewster

Received: 29 July 2022;  Published: 16 January 2023;  doi: 10.21926/obm.icm.2301006

There is increasing evidence for the effectiveness of brief, group-based compassionate mind training (CMT) in reducing shame and self-criticism, and increasing self-compassion. The current evaluation of an 8-week CMT group programme in an NHS Physical Health Psychology Service supports these findings. Based on a cross-diagnostic sample of 25-39 participants with physical health difficulties, results demonstrate significant reduction in depression and anxiety, significant increase in perceived wellbeing and acceptan [...]

by Jiankang Jin  , Shumei Song  and Jaffer A. Ajani

Received: 30 June 2020;  Published: 16 September 2020;  doi: 10.21926/obm.genet.2003116

Gastric adenocarcinoma (GAC) is among the three most common cancers in the world. The majority of GAC patients are diagnosed in an advanced stage and have a median survival of ~9 months. There are limited effective therapeutic strategies available in the clinic and currently U.S. Food and Drug Administration (FDA) approved immune therapy is programmed death-1 (PD-1) antibodies (e.g. pembrolizumab) but only a few patients seem to benefit. Transformation to cancer occurs when multiple genes and cellular pathways are [...]

by Paul M. Valliant  , Charlotte Aelick  , Amber Sinclair  and Joseph M. Caswell

Received: 07 August 2018;  Published: 18 October 2018;  doi: 10.21926/obm.geriatr.1804015

Background: Previous research has indicated the attitudes that others have toward older adults play an important role in their well-being. The current study contributes to the literature because it evaluates attitudes toward older adults. Methods: The participants included Caucasian and Indigenous people residing in Northern Ontario. All participants were asked to complete a demographics questionnaire and the Kogan’s Attitudes Toward Old People Scale (KAOP). Results: Results indicated that Indigenous participants h [...]