Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await
Abstract
1865 9850
Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures AwaitAbstract
Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a century of pharmacological failures in stopping or slowing the disease, there is a need to examine how the simplified cause evolved and to explore alternate approaches to understanding Alzheimer’s disease. Going beyond the nar [...] 1865 9850 |
Converting CO2 from a Harmful Gas to a Renewable Source of Matter and Energy: A ReviewAbstract
The emission of greenhouse gases, specifically CO2, has reached non-acceptable levels causing global warming with adverse effects. Owing to rigorous ongoing research, these harmful substances might be converted to beneficial sources. The main objective of this study was to review the most effective processes that might utilize carbon dioxide to produce various substances, chemicals, and energy. For this, different existing and projected short-term and long-term strategies have been presented and discussed. Specific [...] 1654 9839 |
Application of Epistemic Uncertainty Analysis and Sensitivity Analysis in Green Construction DesignAbstract
Building performance is often expressed according to primary energy use; however studies should also include environmental load. To mitigate the effects of increased CO2 emissions, green building designs are now increasingly popular options for stakeholders. In contrast, impacts of green design parameters, building performance assessment, and design optimization objectives are not addressed sufficiently for American infrastructure. Designing low-energy architecture to minimize carbon emissions requires thoughtful a [...] 1289 9835 |
Comparing the Perspectives of Professionals and Relatives Toward the Quality of Palliative Care: A Qualitative StudyAbstract
High-quality care is an important aim of palliative care services. However, the quality of care is a complex phenomenon and is subjectively perceived by those who are closest to the services and are often evaluated poorly. Prior research has highlighted the difficulties in evaluating the quality of care because of different perspectives, and still, only a little is understood about the perception of the quality of care in palliative care services. Investigating the perspectives of key individuals involved in pallia [...] 1957 9835 |
Understanding Mental Health Needs and Predictors of Anxiety in Emirati Female Students in Higher EducationAbstract
The prevalence rates of depression, anxiety, and stress range between 5% to 70% globally. Many students experience these mental health conditions as they go through transitional periods in life, such as starting higher education. This study aimed to explore mental health concerns, specifically depression, anxiety, stress, and quality of sleep, in Emirati female university students, a topic that has been understudied in the Middle East. We used the Depression, Anxiety, and Stress Scales (DASS-21) and the Pittsburgh [...] 1086 9834 |
Standardized Precipitation Index Comparison along the Limbe-Bamenda Axis of the Cameroon Gulf of GuineaAbstract
Mean monthly rainfall decline with continentality is a commonplace phenomenon that has been used in this study to compare its trend in Bamenda in the Western Highlands and Limbe on the Atlantic lowland coast. This study attempts to bridge some of the methodological gaps in the previous studies on rainfall variability in Cameroon that had emphasized only the inter-annual variability and coefficient of variation without focusing on the specific indices and contrasts between different ecological zones. In this study, [...] 1410 9831 |
Gender-Dependent Effects of Endocrine Disrupting Chemicals on Retinoic Acid-Related Orphan Receptor Alpha [RORA] and Aromatase Genes on Human Progenitor NeuronsAbstract
Normally we encounter a myriad of chemicals in our daily lives. Endocrine disrupting chemicals [EDCs] are ubiquitous in our environment and upon bodily entry many be stored in adipose tissue and, in pregnant woman, can reach the developing fetal brain, disrupting normal fetal brain development. EDC-induced aberrant levels of sex hormones can alter sexual dimorphism [i.e. degree of feminization or masculinization; sex differences in brain and behavior] and may contribute to the differential susceptibility of males a [...] 1280 9817 |
Computational Micromechanics for the Optimization of Compression Strength of Unidirectional Carbon Fiber Composites for Use in Wind Turbine Bladesby
Abstract
As wind turbine blades grow longer, new design parameters gain additional importance such as blade weight, tip deflection and material cost. These parameters require designers to relook at carbon fiber as a potential design solution. However, the composite materials in wind turbine blades are subjected to significant compressive loading, and the compressive strength of carbon fiber reinforced polymer (CFRP) composites is much lower than its tensile strength. This reduction in compression strength is due to a change [...] 1764 9817 |
Experimental DNA- or RNA-Directed Therapies for Trinucleotide Repeat DiseaseAbstract
Some repeats of three or more nucleotides in tandem, which are present in a gene or in its vicinity, tend to increase in number and for this reason are called dynamic mutations. These triplet repeats are unstable and can expand from one generation to the next. According to the expansion size, an unaffected individual can carry a pre-mutation that will expand through generations leading to the development of triplet repeat expansion diseases. The increase in the number of repeats over time leads to earlier developme [...] 2086 9815 |
Satisfaction with Social Life and Academic Adaptation in Students with Different Types of Loneliness in the Process of Distance Learning During the COVID-19 PandemicAbstract
In an age when publicity is the norm, human loneliness is a significant socio-psychological problem. Objective loneliness (e.g., as experienced during the pandemic) does not always result in subjective loneliness. Subjective loneliness directly influences various aspects of the human psyche and activities. Analysis of satisfaction with social life, as a marker of social well-being and academic adaptation of students with different loneliness types, allows determining the magnitude of subjective loneliness and how i [...] 1432 9813 |
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