by Daicia Price  , Yatesha Robinson  , Hurley Riley  , Julie Ribaudo  , Chris Giang  , Todd I. Herrenkohl  and Alison L. Miller

Received: 21 March 2023;  Published: 21 November 2023;  doi: 10.21926/obm.icm.2304055

Adverse and traumatic childhood experiences can have profound negative health and mental health consequences across the lifespan. Prevention and early intervention strategies to mitigate such impacts and foster resilience are essential, yet extant approaches often do not consider the systemic nature of trauma exposure, particularly among communities most impacted by the COVID-19 pandemic and historic disinvestment. Addressing the impacts of trauma early in life is critical in order to mitigate their long-term effec [...]

by Andrew Williams  and Murray Thomson

Received: 25 September 2022;  Published: 13 December 2022;  doi: 10.21926/jept.2204041

This paper sets out a quantified scenario for the UK to reach net zero carbon emissions. Wind and solar are the main energy sources and their intermittency is accommodated through hydrogen electrolysis, biogas from anaerobic digesters, and their combination into biomethane. Hydrogen and biomethane stocks are tracked. A daily energy balance model is presented, using the most recent recorded weather data-2017 to 2021. Long periods of low wind in 2021 indicated the necessary energy storage capacities, which were adjus [...]

by Razieh Sadraei

Received: 25 April 2020;  Published: 01 July 2020;  doi: 10.21926/rpm.2003017

A literature survey shows that the valorization of urban and/or agricultural biowastes into chemicals has caught the attention of experts and is gradually becoming quite an important issue. This review presents the application of the Bio-Based Substances (BBS) isolated from the compost of bio-wastes from urban gardening and park trimming residues. The non-cost BBS has been well studied in the literature. BBS are biological macromolecules with a complex lignin-derived structure containing several functional groups, [...]

by Thomas Liehr  , Monika Ziegler  , Nadezda Kosyakova  and Ahmed B.H. Al-Rikabi

Received: 16 March 2018;  Published: 17 May 2018;  doi: 10.21926/obm.genet.1802021

Background:Fluorescence in situ hybridization (FISH) can be performed on metaphase- and/or interphase cells. Metaphase cells can exclusively be obtained and studied after time-consuming cell culture. Therefore, this technique is suitable only for cells derived from peripheral blood, bone marrow or fibroblasts, the latter including skin, tumour or "prenatal tissues", such as the amnion or chorion. On the other hand, interphase cells can be gained from many different cells and even without cell culture. Methods:Here, [...]

by Ashley Lahr  , Nadene Henderson  , Lee Williams  , Georgianne Arnold  and Damara Ortiz

Received: 14 June 2023;  Published: 25 September 2023;  doi: 10.21926/obm.genet.2303194

Lysosomal storage disorders (LSD) are caused by enzymatic failure to degrade specific cellular byproducts of metabolism within the lysosome. They have a wide range of presentations involving multiple body systems and can manifest from infancy through adulthood. As treatments have become available for many of these disorders, newborn screening has been adapted for early identification and pre-symptomatic treatment. This article will review some of the LSD that are now being added to newborn screening panels, includi [...]

by Vladimir Bashkin  , Andrey Alekseev  , Boris Levin  and Evgenia Mescherova

Received: 17 October 2022;  Published: 28 January 2023;  doi: 10.21926/aeer.2301012

The review article discusses the application of biogeochemical technologies aimed at restoring biogeochemical cycles in agroecosystems, primarily in the microbial link regulating CO2 flows. The factors of management this microbial link when applying mineral and organic fertilizers are shown. The processes of mineralization of soil organic matter and methods of controlling soil's conjugate carbon- and nitrogen-mineralizing ability are considered. The changes in the productivity of agricultural ecosystems under c [...]

by Kosuke Shigematsu  , Yukiko Mikami  , Mamiko Shinsaka  , Masanobu Kinoshita  and Yasushi Takai

Received: 29 June 2022;  Published: 28 March 2023;  doi: 10.21926/obm.genet.2301179

Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease often resulting in more severe symptoms in affected children. The number of CTG repeats is reportedly related to congenital myotonic dystrophy 1 (CDM) severity. In this study, we aimed to clarify whether the number of CTG repeats can predict the severity of symptoms in children with CDM. This retrospective study examined 14 women with DM1 and their 14 children diagnosed with CDM. There were 11 CDM and 3 non-CDM patients. The correlation betwee [...]

by Elham Amjad  , Babak Sokouti  , Solmaz Asnaashari  and Siavoush Dastmalchi

Received: 29 August 2024;  Published: 17 December 2024;  doi: 10.21926/obm.genet.2404275

This systematic review examines the role of SnRK2 (Sucrose non-fermenting 1-Related protein Kinase 2) genes in Arabidopsis thaliana growth and responses to abiotic stresses. SnRK2 protein kinases are key components of abscisic acid (ABA) signaling and osmotic stress responses in plants. The review synthesizes findings from numerous studies on how different SnRK2 genes regulate Arabidopsis growth, development, and stress tolerance at various life stages. Key topics covered include SnRK2 functions under environmental [...]

by Siva Mahendran  , Paramit Chowdhury  , Ronan Breen  , Grainne d’Ancona  and Heather J. Milburn

Received: 14 August 2020;  Published: 08 March 2021;  doi: 10.21926/obm.transplant.2101137

Patients with chronic kidney disease (CKD) have an increased risk of developing tuberculosis (TB) compared to those with normal renal function. The reasons for this are well described, but include impaired cellular immunity, a high incidence of co-morbid conditions as well as the concomitant use of immunosuppressive medications. Ethnicity as well as socio-economic factors also prevail. Expert guidelines recommend TB chemoprophylaxis in renal transplant recipients deemed at high risk – invariably those from ethnic m [...]

by Joep Geraedts

Received: 05 June 2018;  Published: 23 July 2018;  doi: 10.21926/obm.genet.1803024

Both preimplantation genetic testing (PGT) and prenatal diagnosis (PND) are powerful tools to tackle the transmission of inherited disorders carried by families from generation to generation. Here, we present an overview of the current landscape of both methods and identify the pros and cons of each of these reproductive options. In prenatal testing, non-invasive diagnostic methods have become available as an alternative for invasive diagnosis. Different genome sequencing strategies have now been introduced that en [...]