by Giuseppe Cocco  and Philipp Amiet

Received: 23 March 2021;  Published: 30 July 2021;  doi: 10.21926/obm.genet.2103133

“Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence” (https://www.cdc.gov/genomics/disease/epigenetics.htm). Epigenetic interactions, along with the genetic expression in innate cells, change the structure and function of chromatin, and thus, turn the genes on and off. Epigenetic changes influence dise [...]

by Yasushi Shibata  , Masayuki Goto  and Sumire Ishiyama

Received: 25 October 2021;  Published: 08 February 2022;  doi: 10.21926/obm.neurobiol.2201115

Magnetic resonance imaging (MRI) has been used to investigate migraine pathophysiology because it is a non-invasive technique. The main aim of clinical imaging for patients with headaches is to exclude secondary headaches due to organic lesions. Conventional structural imaging techniques such as routine MRI demonstrate white matter lesions, changes in gray matter volume or cortical thickness, and cerebral blood flow in patients with migraine. Changes in metabolite levels are observed by magnetic resonance spectrosc [...]

by Sydney Rudowski  , Cornelius F. Boerkoel  , Miao He  and Shibani Kanungo

Received: 20 April 2023;  Published: 05 October 2023;  doi: 10.21926/obm.genet.2304195

After the completion of the human genome project, there have been many advances in the field of genetics. With next generation sequencing, patients can undergo genomic analysis through whole exome or whole genome testing. These comprehensive tests can shorten the diagnostic odyssey and guide medical management and thereby potentially reduce mortality and morbidity. To date, parents and physicians have reported positive perceptions of using these genomic testing even when a diagnosis is not made. Remaining challenge [...]

by Abdullah Abbas Kendoush

Received: 04 October 2021;  Published: 07 December 2021;  doi: 10.21926/jept.2104048

By the adoption of a drag-buoyancy equality model, analytical solutions were obtained for the drag coefficients (CD) of Taylor bubbles rising steadily in pipes. The obtained solutions were functions of the geometry of the Taylor bubble and the gas volume fraction. The solutions were applicable at a wide range of Capillary numbers. The solution was validated by comparison with experimental data of other investigators. All derived drag formulas were subject to the condition that Bond number >4, for air-water syste [...]

by Wolf-Dieter Heiss

Received: 02 July 2018;  Published: 19 September 2018;  doi: 10.21926/obm.neurobiol.1803011

Gliomas originating from glial cells comprise about 30% of all primary central nervous system tumors and 80% of malignant brain tumors. Gliomas differ in their biological activity and are categorized according to grades, from benign to malignant with high recurrence rates. For diagnosis, location and extent of the tumor is assessed by CT and MRI, but for grading, additional parameters are necessary: contrast enhanced CT and MRI reveal damage of the blood–brain barrier, perfusion-weighted MRI shows regional blood su [...]

by Ezgi Cabuk Sahin  , Yildiz Aydin  and Ahu Altinkut Uncuoglu

Received: 17 May 2024;  Published: 02 September 2024;  doi: 10.21926/obm.genet.2403260

Molecular markers play a crucial role in accelerating crop production for sustainable agriculture by identifying resistant traits and enhancing genetic diversity. In this review, we examine the impact of the molecular markers on advancing our understanding of stress tolerance mechanisms in plants, addressing the pressing imperative to bolster global food production to meet the escalating demands of the growing population. Additionally, the application of molecular markers to evaluate the genetic accuracy of plants [...]

by Owen Sedej  , Eric Mbonimpa  , Trevor Sleight  and Jeremy Slagley

Received: 18 February 2022;  Published: 18 August 2022;  doi: 10.21926/jept.2203027

Waste-to-Energy technologies have the potential to dramatically improve both the natural and human environment. One type of waste-to-energy technology that has been successful is gasification. There are numerous types of gasification processes and in order to drive understanding and the optimization of these systems, traditional approaches like computational fluid dynamics software have been utilized to model these systems. The modern advent of machine learning models has allowed for accurate and computationally ef [...]

by Holly Hazlett-Stevens

Received: 12 April 2022;  Published: 07 June 2022;  doi: 10.21926/obm.icm.2202022

Mindfulness-based stress reduction (MBSR) teaches mindfulness meditation to reduce stress, anxiety, depression, and related forms of distress among a variety of patients. Much research has documented statistically significant reductions across a variety of self-report measures following MBSR, but researchers rarely assessed and reported the clinical significance of MBSR symptom reduction in accordance with specific criteria famously established by Jacobson and Truax [1]. Patients reporting symptoms of anxiety, depr [...]

by Étienne Cusson  , Jean-Christophe Mougeot  , Mélanie Maho  , Florian Lacroix  , Ali Fazli  and Denis Rodrigue

Received: 01 March 2022;  Published: 11 April 2022;  doi: 10.21926/aeer.2202012

Recycled styrene butadiene rubber (rSBR) from waste car tires was used as a filler in poly(lactic) acid (PLA) to modify its properties. The compounds were prepared via twin-screw extrusion and molded by injection with different rSBR contents (0 to 25% wt.). Additionally, recycled rubber particle size was controlled between 125 and 1000 μm to determine the effect of this parameter. From the samples produced, a series of morphological, physical and mechanical characterizations were performed. As expected, rSBR additi [...]

by Thaninee Prasoppokakorn  , Supachaya Sriphoosanaphan  , Nutbordee Nalinthassanai  , Thitaporn Roongrawee  , Pongtorn Hanboonkunupakarn  , Pisit Tangkijvanich  and Rungsun Rerknimitr

Received: 08 December 2023;  Published: 02 February 2024;  doi: 10.21926/obm.icm.2401013

Reports indicate that Andrographolide inhibits viral replication and reduces COVID-19 symptoms. This study aimed to determine Andrographolide's additional effect and safety in mild COVID-19 patients treated with favipiravir. A multicenter, open-labeled, randomized controlled trial was conducted from October 2021 to February 2022. The patients were randomized to receive a combination of Andrographolide and favipiravir or favipiravir monotherapy. The primary outcome was the occurrence rate of severe pneumonia. The se [...]