by Gerhard Litscher

Received: 27 May 2016;  Published: 15 August 2016;  doi: 10.21926/obm.icm.1601001

Integrative and Complementary Medicine (ICM-OBM) is an international peer-reviewed, open-access journal which covers all evidence-based scientific studies on integrative and complementary approaches to improving health and quality of life. Integrative and complementary medicine comprises science-oriented “university” or academic medicine, but also experience-based medicine with all its complementary methods. It is not a special field in itself, but a signal for an all-encompassing medicine, open-minded about the p [...]

by Alireza Modir  , Arnaud Casterman  and Ibrahim Tansel

Received: 10 January 2023;  Published: 26 July 2023;  doi: 10.21926/rpm.2303028

The process of metal additive manufacturing (AM) involves creating strong, complex components by using fine metal powders. Extensive use of AM methods is expected in near future for the production of small and medium-sized batches of end-use products and tools. The ability to detect loads and defects would enable AM components to be used in critical applications and improve their value. In this study, the Surface Response to Excitation (SuRE) method was used to investigate wave propagation characteristics and load [...]

by Ioannis Syros  , Panagiota Pervanidou  , Charis Liapi  , Filia Apostolakou  , George P Chrousos  and Gerasimos Kolaitis

Received: 01 March 2020;  Published: 11 June 2020;  doi: 10.21926/obm.neurobiol.2002060

Data available on possible associations of lipids, steroid levels, and depression are conflicting. This study investigated their possible associations in a sample of youth with depression. Ninety-eight youth with depression and individually matched healthy volunteers on the basis of age and sex were enrolled for the study. The two groups had nearly similar body mass index. After fasting overnight, they underwent blood sampling for triglycerides (TG), total cholesterol, low-density lipoprotein, high-density lipoprot [...]

by Sofia Silva  , Alexandra Cravo  , João Rodrigues  , Cátia Correia  and Cristina M.M. Almeida

Received: 09 April 2021;  Published: 19 June 2021;  doi: 10.21926/aeer.2102015

The use of biomarkers in bivalves has gained significance as a reliable method for the assessment of the presence and effect of contaminants in aquatic ecosystems. However, it is important to note that the biomarkers respond not only to contaminant loadings and bioavailability but also to environmental stress. Therefore, the association between biomarkers and contamination/pollution should be conducted cautiously as the environmental factors also affect their response. These factors should be integrated into the as [...]

by Roy G Beran

Received: 30 November 2022;  Published: 13 February 2023;  doi: 10.21926/obm.geriatr.2301223

This paper reviews the relationship between RBD and PD and the pathophysiology. Most RBD patients develop PD within 14 years. PD pathophysiology is α-synucleinopathy with dopamine degeneration in nigrostriatal pathways. RBD pathology is poorly understood. Anomalies suggest RBD and PD are different, evidenced by smoking. RBD and PD are associated with glucocerebrosidase gene mutations (GBA gene), suggesting RDB with GBA gene mutation predicts PD. PET imaging, assessing vesicular monoamine transporter 2 (VMAT2), inde [...]

by Tran X Phuoc  and Mehrdad Massoudi

Received: 28 October 2021;  Published: 22 December 2021;  doi: 10.21926/jept.2104050

To store CO2 in geological reservoirs, expansion valves have been used to intentionally release supercritical CO2 from high-pressure containers at a source point to lower-pressure pipelines and transport to a selected injection site. Using expansion valves, however, has some shortcomings: (i) the fluid potential, in the form of kinetic energy and pressure which can produce mechanical work or electricity, is wasted, and (ii) due to the Joule-Thomson cooling effect, the reduction in the temperature of the released CO [...]

by Alla V. Balueva  , Ilia N. Dashevskiy  and Patricia Todebush

Received: 12 May 2021;  Published: 27 October 2021;  doi: 10.21926/rpm.2104043

One of the ways to improve the fusion of an implant with bone tissue is through the use of biocompatible coatings, in particular, hydroxyapatite (HAp). It is important to assess the strength of the HAp adhesion to the implant. The measure of the strength of the bond of the coating with the substrate is the energy of this bond. Using density functional theory and molecular dynamics, the reaction path, reaction products, oscillation frequency, activation energy and bond energy between different combinations of compon [...]

by Vineela Nagamalla  , Jay Patel  and Mir Saleem

Received: 20 December 2020;  Published: 21 July 2021;  doi: 10.21926/obm.neurobiol.2103104

Alzheimer’s disease (AD) is a neurodegenerative condition which consists of stages of mental, memory, and cognitive decline. As it continues to stand as the sixth leading cause of death in the U.S., 44 million people worldwide are affected. The objective of this paper is to explore the risk factors for AD in an attempt to examine potential causes for the incidence of AD. We examined genetics, lifestyle, and pre-existing conditions as risk factors for AD. We found that there are various alleles, such as APP, P [...]

by Junhyeong T. Park  , Junseong A. Park  , Igor F. Tsigelny  and Valentina L. Kouznetsova

Received: 07 December 2021;  Published: 13 February 2022;  doi: 10.21926/obm.genet.2201147

The occurrence of various mutation patterns, such as changes in the DNA sequence and the loss of some sequences, is called a “mutational signature,” and they represent the molecular fingerprints that exist for the type of mutation occurring in a specific gene. Our study elucidates the correlations of mutational signatures in frequently mutated cancer genes with general mutational signatures previously found for different cancers. We hypothesized that the top twenty most frequently mutated genes (MFMG) of a cancer t [...]

by Laura A. Huppert  , Marie Sinclair  and Jennifer C. Lai

Received: 08 November 2018;  Published: 28 November 2018;  doi: 10.21926/obm.transplant.1804028

Background: Patients with cirrhosis suffer not only from commonly-diagnosed portal hypertensive complications such as ascites and hepatic encephalopathy but also from more insidious effects of chronic liver failure including muscle wasting, under-nutrition, and functional decline. These manifestations of physical frailty have been demonstrated to predict mortality in patients with cirrhosis independently of liver disease severity, but objective biomarkers associated with physical frailty in cirrhosis are needed. Th [...]