by Avneet K. Mangat  and Georg M. Schmölzer

Received: 07 June 2019;  Published: 20 August 2019;  doi: 10.21926/obm.icm.1903051

The incidence of Neonatal Abstinence Syndrome (NAS) is increasing due to more mothers using illicit drugs. This results in an increase in costs and resources for the healthcare system. Newborns with NAS might experience withdrawal symptoms that can cause pain, distress, and may potentially increase the risk of future health complications. It is therefore important to find effective treatments that can alleviate NAS. Various non-pharmacological treatments are used in conjunction with pharmacological treatments to re [...]

by Samuel Brennan  , Matthew Keon  , Zheng Su  , Bing Liu  , Xiao Min Song  , Thiri Zaw  , Matthew McKay  , Donna Pascovici  and Nitin K. Saksena

Received: 21 August 2020;  Published: 29 March 2021;  doi: 10.21926/obm.geriatr.2101164

There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. Here we describe an ALS patient, who by choice, received allogeneic human cord-blood derived multipotent stem cells (MSC) intravenously and intrathecally. This is the first snapshot of pre-and post-stem cell transplantation in an ALS patient through transcriptomic, epigenomic, and proteomic follow-up elucidating the effect of stem cells in [...]

by Alberto Ferrarese  , Marco Senzolo  and Patrizia Burra

Received: 29 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.transplant.2002110

Bacterial infection represents a common event in the natural history of cirrhosis, especially in patients with end-stage liver disease. An episode of bacterial infection may significantly modify a patient’s outcome in the setting of liver transplantation (LT) by impairing hepatic and extrahepatic organ functions, both in pre-operative and post-operative phases. Infections caused by multidrug-resistant organisms (MDRO) are increasing in cirrhosis due to high antibiotic exposure and hospitalizations. This issue is pa [...]

by Jade M Kozuch  , Kamyar Afshar  and Ashley Feist

Received: 15 November 2024;  Published: 20 February 2025;  doi: 10.21926/obm.transplant.2501235

Lung transplant recipients represent a high-risk group for cytomegalovirus (CMV) infection and disease, even among solid organ transplant (SOT) recipients, due to multiple factors. Additionally, CMV has significant consequences in this group including pneumonitis, acute rejection, and chronic lung allograft dysfunction. For the past two plus decades, treatment of CMV in SOT recipients has been limited to off-label use of 4 antiviral medications associated with significant toxicities including myelosuppression and n [...]

by Melanie J. Chandler  , Michelle Graff Radford  , Pauline Lucas  , Dona E.C. Locke  , Julia Crook  , Colleen Ball  , Maria Caselli  , Angela Lunde  , Vaishali Phatak  and Glenn E. Smith

Received: 30 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101147

Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our research also has shown yoga helps sustain positive psychological well-being of care partners at 12 months. In this analysis, we sought to examine the impact of yoga training on physical performance in pwMCI and their care partners. In this multisite, randomized clinical trial, we enrol [...]

by Masahiro Sato  , Issei Saito  , Eri Akasaka  and Emi Inada

Received: 11 October 2020;  Published: 10 March 2021;  doi: 10.21926/obm.genet.2101126

Direct colony cloning of adherent mammalian cells using rings or dilution cloning has been used frequently for obtaining stable transfectants after gene delivery. As an alternative to these methods, successful isolation of the cells in a single colony is possible by placing a trypsin-immersed small paper disk onto the colony and subsequently picking up the paper with the assumption that it carries the trypsinized cells. However, the cloning success using this technique largely relies on the cell type used. In the p [...]

by Line L. Olesen

Received: 01 February 2020;  Published: 21 April 2020;  doi: 10.21926/obm.geriatr.2002115

The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardized and its usage has declined, digoxin intoxication still occurs frequently. Due to the risk of fatal complications, it has a negative prognosis. The knowledge about the etiology and symptoms of intoxication is critical f [...]

by Andrew Williams  and Murray Thomson

Received: 09 November 2022;  Published: 09 January 2023;  doi: 10.21926/jept.2301003

This paper examines the economic case for the UK to proceed urgently with the installation of thermal insulation and heat pumps in most UK buildings, in the context of the legal requirement to achieve net-zero carbon emissions by 2050. A recent study by the same authors assumed that such insulation and heat pumps would be in place, and showed how the whole of the UK’s energy demand could be met by low carbon electricity generation and appropriate storage. This paper extends the modelling to consider the risk that i [...]

by Diane B. Paul  and Ilana Löwy

Received: 16 April 2018;  Published: 12 June 2018;  doi: 10.21926/obm.genet.1802022

We address an ongoing controversy over what health-care providers tell prospective parents about Down Syndrome (DS). Many parent, disability-rights, and anti-abortion activists believe that the messages that health-care professionals transmit to pregnant women and their partners are distorted. In their view, OB-GYNs, primary-care providers, clinical geneticists, midwives and other medical professionals generally assume that the quality of life for individuals with DS and their families is poor, whereas in fact, tho [...]

by Peta Stapleton  and Hannah Chatwin

Received: 17 May 2018;  Published: 02 July 2018;  doi: 10.21926/obm.icm.1803014

(1) Background: Because patients vary in their response to treatment, including adherence, the effect of treatment length in the use of EFT on food cravings was examined by comparing two studies in order to ascertain if shorter programs are as effective. This may then impact treatment adherence and completion. (2) Methods: In study one, 96 overweight and obese adults were randomly allocated to a 4-week treatment for their food craving or waitlist condition. In study two, an 8-week EFT program for 47 adults, the sam [...]