by Shoichiro Sumi  , Sin-Yu Yang  , Priyadarshini Canning  and Kai-Chiang Yang

Received: 29 May 2019;  Published: 24 July 2019;  doi: 10.21926/obm.transplant.1903074

Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, recent clinical trials show that micro-encapsulated islets are not fully retrievable after transplantation. By contrast, macro-encapsulated islets can be retrieved when necessary. As to the transplantation site, subcutaneous tissue can be promising, if new [...]

by Divya B. Mella  , Josie Sewell  and Edward Pan

Received: 12 October 2018;  Published: 01 November 2018;  doi: 10.21926/obm.neurobiol.1804014

Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent used in gliomas, which has been given to patients with prolactinomas refractory to conventional treatments. Methods: Retrospective chart review was conducted for refractory prolactinoma patients treated between 2008 and 20 [...]

by Victoria M. Dahl  , Alyssa L. Chimiklis  , Sarah Peralta  , Yasmin Siddiqui  and Anil Chacko

Received: 15 August 2024;  Published: 18 March 2025;  doi: 10.21926/obm.icm.2501015

Schools have made commendable efforts to incorporate yoga and mindfulness programs to address the wellbeing of students; however, research on the efficacy of school-based yoga and mindfulness programs is still in its infancy, particularly with school-aged students at risk of developing externalizing disorders. Much of the research has also focused on evaluating interventions implemented by researchers, rather than evaluating those implemented by the school and its staff. The aim of this pilot study was to evaluate [...]

by Firas AL-Rshoud  , Lina Almahmoud  , Nagham Younis  , Rnad AL. Ajarmeh  and Ahmad M. Fares

Received: 02 January 2024;  Published: 07 March 2024;  doi: 10.21926/obm.genet.2401222

This study aims to assess the Trophectoderm (TE) biopsy practice in Jordan in terms of the following effectiveness parameters: timing of zona breaching, risk of inner cell mass herniation if zona breaching was done on day 3, timing of TE sampling, method of biopsy (pulling or flicking), number of laser pulses, assessment of embryo survival after biopsy, and degeneration rate. An online cross-sectional survey was conducted in November 2022. The collected data presented the perception of embryologists (>10 years e [...]

by Jamylle Yanka Cruz Ribeiro  , Ronaldo Santos da Silva  , Giancarlo Richard Salazar-Banda  and Katlin Ivon Barrios Eguiluz

Received: 06 September 2022;  Published: 19 January 2023;  doi: 10.21926/cr.2301005

This paper describes the synthesis of Pd0.70-Nix-By nanoparticles (x:y = 0.30:0, 0:0.30, 0.25:0.05, 0.20:0.10, 0.15:0.15, and 0.10:0.20) supported on carbon Vulcan XC-72 R by the chemical reduction method using ethylene glycol as a reducing agent for the study of the electrochemical oxidation of ethanol in alkaline media. Neither surfactants nor templates were used during the syntheses. The catalysts were physically characterized by transmission electron microscopy that showed the formation of nanoparticles with di [...]

by Robert J. Hoss  , Lynne M. Hoss  and Dawson Church

Received: 25 January 2022;  Published: 05 July 2022;  doi: 10.21926/obm.icm.2203024

The purpose of this paper is to demonstrate that the integration of dreamwork and Energy Psychology (EP) can enhance outcomes in the treatment of a range of psychological disorders. The therapeutic process often begins with a peeling away of emotional layers until underlying issues surface. When utilizing dreamwork, however, it is possible to begin at a deeper level. Because dreams address salient unresolved emotional conflicts, dreamwork can quickly bring into consciousness previously unconscious emotional issues [...]

by Edwin Meresh  , Clinton Korneffel  , Bavani Rajah  and Ryan Bergren

Received: 23 December 2020;  Published: 23 March 2021;  doi: 10.21926/obm.neurobiol.2101089

Catatonia can occur in patients diagnosed with schizophrenia and bipolar disorder and malignant catatonia is life threatening. Anti-psychotic medications should be discontinued during acute phase of catatonia. Anti-psychotic discontinuation in catatonia is a challenge in patients maintained on long-acting injectable antipsychotics because of the extended release. Case report: We present a case of malignant catatonia developed in a patient with history of schizophrenia and developmental delay. Symptoms lasted severa [...]

by Masahiro Sato  , Emi Inada  , Satoshi Watanabe  , Issei Saitoh  , Naoko Kubota  , Yoko Iwase  , Kazunori Morohoshi  and Shingo Nakamura

Received: 31 August 2025;  Published: 24 November 2025;  doi: 10.21926/obm.genet.2504317

An episomal vector is a plasmid- or virus-based vector that is present extrachromosomally in cells after transfection. Although it disappears during cell proliferation, it can exist in non-dividing cells, such as neuronal and muscular cells, and continues to express a gene of interest (GOI). Such episomal vectors are usually based on sequences from DNA viruses such as bovine papillomavirus 1 and Epstein-Barr virus. When cells are transfected with an episomal vector harboring a drug-resistance gene and subsequently [...]

by Thibaut Triquet  , Claire Tendero  , Laure Latapie  , Romain Richard  and Caroline Andriantsiferana

Received: 20 January 2022;  Published: 15 March 2022;  doi: 10.21926/cr.2201007

This work reports the performance of a sequential adsorption/photocatalysis process using activated carbon fibers with deposited TiO2 for the elimination of the antibiotic ciprofloxacin (CIP) in water. A commercial activated carbon fiber (ACF10) was selected as the support, and a TiO2 coating was synthesized using Metal Organic Chemical Vapor Deposition (MOCVD). Experiments were carried out using a photocatalytic reactor irradiated with monochromatic LEDs (365nm). Two different processes have been studied: adsorpti [...]

by Ugo Testa  , Germana Castelli  and Elvira Pelosi

Received: 27 May 2020;  Published: 06 August 2020;  doi: 10.21926/obm.genet.2003114

Cancer is characterized by sequential and progressive genetic and epigenetic alterations in key proto-oncogenes and tumor suppressor genes, which ultimately lead to tumor development. Advances in the technology of analysis of molecular mechanisms have increased the efficiency of clinical management of cancer patients. Recent years have witnessed a progressive development in technologies that enable the detection of specific molecular abnormalities associated with various types of solid tumors in body fluids, a proc [...]