by Verena Hofmann  , Céline Pagnotta  , Noémie Lacombe  and Myriam Squillaci

Received: 30 March 2023;  Published: 10 August 2023;  doi: 10.21926/obm.icm.2303033

Burnout is a syndrome commonly characterized by the three dimensions of Maslach and Leiter's model, namely emotional exhaustion, depersonalization, and lack of professional accomplishment. While burnout affects individuals in all professions, teachers are recognized as being at particular risk, a fact explained in the literature by the high level of relational demands inherent to the profession. During the pandemic and subsequently, these demands have even increased. Several studies have focused on the influence of [...]

by Jasmine French  , Richard J. Brown  and Tobyn Bell

Received: 25 August 2023;  Published: 11 October 2023;  doi: 10.21926/obm.icm.2304041

Soothing-rhythm breathing (SRB) is a core component of compassion focused therapy (CFT). While integral to CFT, research has yet to explore personal experiences of SRB. This study aimed to explore the experiences of individuals with depression who had practiced SRB in NHS primary care services. Interpretative phenomenological analysis (IPA) was used to analyse data from individual semi-structured interviews. Three experiential themes were identified: ‘mind-body connection and bodily needs’, ‘a new relationship with [...]

by Ana Valado  , Polina Ponedilok  , Armando Caseiro  and Leonel Pereira

Received: 22 July 2023;  Published: 29 November 2023;  doi: 10.21926/rpn.2304024

Noncommunicable diseases (NCD), such as cardiovascular diseases (CVD), are responsible for the majority of annual deaths worldwide. Dyslipidemia, hypertension, diabetes, and obesity, among others, can enhance the onset of metabolic syndrome (MetS). The integration of natural products in the diet, such as marine macroalgae or hydrocolloids extracted from them, has been extensively studied. The application of these substances in the prevention of pathologies is expanding due to the high content of bioactive compounds [...]

by Yoram Barak  and Paul Glue

Received: 04 October 2018;  Published: 26 November 2018;  doi: 10.21926/obm.geriatr.1804021

Patients with AD have shortened life expectancy than the general older population is well established. Loneliness may be another risk factor to consider if we wish to understand and improve the premature mortality of AD.

by David C. Gaston  and Marwan M. Azar

Received: 14 November 2018;  Published: 29 December 2018;  doi: 10.21926/obm.transplant.1804037

The approach to diagnosing fungal infections following solid organ transplantation (SOT) is patient-specific. An assessment of an individual’s risk for particular infections, also understood as the pre-test probability, should guide appropriate diagnostic testing whereas diagnostic stewardship is needed to produce interpretable, actionable and cost-sensitive results. This review provides a cognitive framework for practitioners aiming to diagnose fungal infections in recipients of SOT, taking into consideration the [...]

by Simon Calles  , Paul Heitjans  and Alexander Börger

Received: 09 November 2021;  Published: 18 April 2022;  doi: 10.21926/jept.2202015

Prismatic PHEV2 form-factor lithium-ion cells with a nominal capacity of 25 Ah (as used for automotive applications) have been studied with electrochemical impedance spectroscopy (EIS). The data was evaluated using electrical equivalent circuits. Mathematical modeling, system identification, and the determination of model parameters of the lithium-ion cell were also carried out. While a study of the influence of temperature and state-of-charge (SOC) performed using pristine lithium-ion cells showed a nonlinear rela [...]

by Joep Geraedts

Received: 08 April 2019;  Published: 14 August 2019;  doi: 10.21926/obm.genet.1903089

Mitochondrial diseases are among the most prevalent inborn errors of metabolism. The overwhelming majority of mitochondrial diseases (about 85%) result from mutations in nuclear genes involved in oxidative phosphorylation, while some (15%) are caused by mutations in mitochondrial DNA (MtDNA). The familial mtDNA mutations are exclusively inherited from the mother. There are four main methods available to prevent the transmission of mtDNA mutations: preimplantation genetic diagnosis (PGD) or prenatal diagnosis (PND) [...]

by Alvin Ho Kwan Cheung  , Nancy Bo-Yin Tsui  , William Chi Shing Cho  , Xiao-Meng Pei  , Yin-Kwan Evelyn Wong  , Hin-Fung Andy Tsang  , Gilberto Ka-Kit Leung  and Sze-Chuen Cesar Wong

Received: 02 May 2020;  Published: 28 June 2020;  doi: 10.21926/obm.genet.2002112

Background: Vestibular schwannoma is an intracranial tumor which can lead to devastating neurological deficit and is prone to recurrence after surgery. Patients with inherited neurofibromatosis type 2 (NF2) syndrome are particularly susceptible to bilateral and aggressive schwannomas. However, the genome of vestibular schwannomas is not well known. There is an imminent need of developing effective chemotherapeutic agents either as a primary treatment modality or as adjuvant therapy for these patients. Methods: Here [...]

by Nicholas Lim  , Gregory Beilman  and Timothy Pruett

Received: 21 March 2018;  Published: 12 June 2018;  doi: 10.21926/obm.transplant.1802011

Portal hypertension often occurs transiently with injection of islet cells into the portal system during total pancreatectomy-islet autotransplantation (TPIAT). We describe a TPIAT patient with non-cirrhotic portal hypertension (NCPH) two years after surgery initially identified with esophageal varices on upper endoscopy. The underlying mechanism for the development of NCPH after TPIAT is unclear but infectious and immune-related pathways have been proposed. Management of NCPH is primarily treatment of complication [...]

by Ashrit Multani  , Libby S. Allard  and Joanna K. Nelson

Received: 03 June 2019;  Published: 29 July 2019;  doi: 10.21926/obm.transplant.1903076

Hematopoietic cell transplantation is frequently complicated by infectious disease-related complications, especially pneumonia. Candida and enterococci are often overlooked as pulmonary pathogens with some clinicians firmly believing that these organisms never cause pneumonia. Here, we present a series of five cases of Candida pneumonia and five cases of enterococcal pneumonia found on autopsy in hematopoietic cell transplantation recipients. We will also review the literature regarding the epidemiology, risk facto [...]