by Kenneth J. McLeod

Received: 24 April 2023;  Published: 18 September 2023;  doi: 10.21926/obm.geriatr.2303249

Chronically low blood pressure in older adults is associated with significantly increased long-term risks of dementia and all-cause mortality risk. Yet low blood pressure is generally not treated until an individual begins to experience the acute symptoms arising from very low cerebral perfusion. However, these acute symptoms, such as dizziness, balance difficulty, syncope, increased fall occurrence, vision impairment, and nausea, begin to occur only at very low blood pressure levels, such that mean arterial pressu [...]

by Siti Hana Nasir  , Olga Troynikov  , Dawn Wong Lit Wan  and Zhen Zheng

Received: 25 February 2019;  Published: 02 September 2019;  doi: 10.21926/obm.icm.1903053

Background: Pressure and thermal therapy gloves are the two types of therapeutic gloves that are commonly used to relieve symptoms and improve hand function in patients with hand arthritis. However, no published clinical study exists indicating ideal pressure and thermal stimuli for the gloves. Understanding user thresholds for the pressure and thermal stimuli is crucial to improve therapeutic outcomes, wearer's comfort, and adherence to the therapy. There were two main aims of this pilot study, firstly to examine [...]

by Melanie J. Chandler  , Michelle Graff Radford  , Pauline Lucas  , Dona E.C. Locke  , Julia Crook  , Colleen Ball  , Maria Caselli  , Angela Lunde  , Vaishali Phatak  and Glenn E. Smith

Received: 30 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101147

Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our research also has shown yoga helps sustain positive psychological well-being of care partners at 12 months. In this analysis, we sought to examine the impact of yoga training on physical performance in pwMCI and their care partners. In this multisite, randomized clinical trial, we enrol [...]

by Bhanuka Maheshwara Sisira Kumara Pahala Ralalage  , Nirmani Kaluarachchi  , Malshani Randunu  , Munshifa Jainulabdeen  , Rohini Nanthakumar  , Sameera Vishwakula  and B. Prasanna Galhena

Received: 01 October 2022;  Published: 06 February 2023;  doi: 10.21926/obm.genet.2301177

Fluorescence In-Situ hybridization (FISH) is a sensitive and highly efficient technique commonly used in routine diagnostics. Most of these tests that use analyte-specific reagents are not approved by US Food and Drug Administration (FDA) but are developed by individual test laboratories. There is an emerging demand for prenatal diagnosis of aneuploidies by FISH. Since most of these assays are laboratory-developed tests, it is essential to validate them prior to their use in diagnosis. However, validation procedure [...]

by Laura Alonso Canal  , María José Quiles Blanco  , David Jiménez Leiva  and María José González Iglesias

Received: 26 June 2019;  Published: 30 September 2019;  doi: 10.21926/obm.hg.1903037

Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The infection of Helicobacter pylori has been linked to multiple immuno-mediated extradigestive conditions including alopecia areata. There is scientific evidence of the usefulness of naltrexone in low doses (an opioid antago [...]

by Em V. Adams  , Marieke Van Puymbroeck  , Brandi M. Crowe  , Cynthia L. S. Pury  and Arlene A. Schmid

Received: 19 August 2020;  Published: 20 October 2020;  doi: 10.21926/obm.geriatr.2004135

Residents of assisted living facilities face leisure constraints (barriers to leisure activities) at higher rates than their community-dwelling peers. Past research suggests yoga may be an effective intervention to decrease leisure constraints to physical activity. Therefore, the purpose of this study was to evaluate the impact of an eight-week yoga intervention on the leisure constraints of residents of assisted living facilities. The study employed a convergent mixed methods design to assess the impact of a 50-mi [...]

by Steven Hespeler  and Donovan Fuqua

Received: 31 July 2020;  Published: 12 January 2021;  doi: 10.21926/jept.2101003

This investigation presents a data-driven Long-short Term Memory battery model for predicting State of Charge for lithium-ion batteries LiFePO4 for next-generation vehicle operations. Our modified algorithm builds and updates a model using multivariate inputs that include physical properties, voltage, current, and ambient temperature during operations. The primary research goal is to improve prediction performance on future values from multiple training examples using an online learning scheme. Initial results demo [...]

by Junmo Moon  , Satita Thiangtham  , Ruijie Zheng  , Sicheng Liu  , Chayanaphat Chokradjaroen  , Yasuyuki Sawada  and Nagahiro Saito

Received: 04 December 2022;  Published: 20 February 2023;  doi: 10.21926/jept.2301010

Crystalline lithium fluoride (LiF) has been intensively pursued as potential alternative solid electrolytes (SEs) owing to its excellent chemical and electrochemical oxidation stability, and good deformability. However, due to its low ion conductivity, LiF is still challenging for practical SE applications. Herein, Li-Zr-F composite-based SE by liquid-mediated synthesis is proposed to be studied. methanol (CH3OH) was mainly evaluated as a liquid-mediated precursor for synthesizing Li-Zr-F composites under the stoic [...]

by Alex T. Von Schulze  , Marie van der Merwe  , Chad D. Touchberry  and Richard J. Bloomer

Received: 03 August 2021;  Published: 15 October 2021;  doi: 10.21926/rpn.2104001

Poor dietary habits can lead to obesity and insulin resistance—both of which can impair basal heat shock protein (HSP) expression and the HSP stress response in skeletal muscle. It remains unclear if impairments in HSP expression occur during the early stages of diet-induced obesity and metabolic dysfunction. We determined if basal HSP expression (HSP70, HSP60, HSP25) was impaired in sedentary or exercised rats following the onset of diet-induced obesity. Male Long-Evans rats (N=6-7/group) were assigned to a [...]

by Jasmine French  , Richard J. Brown  and Tobyn Bell

Received: 25 August 2023;  Published: 11 October 2023;  doi: 10.21926/obm.icm.2304041

Soothing-rhythm breathing (SRB) is a core component of compassion focused therapy (CFT). While integral to CFT, research has yet to explore personal experiences of SRB. This study aimed to explore the experiences of individuals with depression who had practiced SRB in NHS primary care services. Interpretative phenomenological analysis (IPA) was used to analyse data from individual semi-structured interviews. Three experiential themes were identified: ‘mind-body connection and bodily needs’, ‘a new relationship with [...]