OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 


Publication Speed (median values for papers published in 2023): Submission to First Decision: 6.7 weeks; Submission to Acceptance: 14.4 weeks; Acceptance to Publication: 6 days (1-2 days of FREE language polishing included)

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Special Issue

Multiple Aspects of Transplant Tolerance – Mechanisms, Strategies, and Barriers

Submission Deadline: September 30, 2018 (Open) Submit Now

Guest Editor

Jean Kwun, PhD

Assistant Professor of Surgery, Duke Transplant Center, Department of Surgery, Duke University Medical Center, 207 Research Dr, Jones 362, Durham, NC 27710, USA

Website | E-Mail

Research Interests: heart transplantation, transplant tolerance, humoral tolerance to organ transplants, mechanisms of antibody-mediated rejection (AMR), establishing a conceptual basis that will translate into therapeutic intervention of AMR

About This Topic

The idea of immunological tolerance was developed from seminal works by Ray Owen, Sir F. MacFarlane Burnet, and Sir Peter Medawar in the mid-20th century. These findings drove transplantation research to identify mechanisms of immune tolerance. However, despite partial success, it was unable to stably induce tolerance in immunocompetent recipients. In the special issue, “Multiple Aspects of Transplant Tolerance”, we will provide a forum for presenting mechanisms, strategies, and challenges for promoting tolerance in transplantation. This will include description of cell populations plays a crucial role in tolerance as well as cell-based approaches (Treg, Mreg, DCreg, CD8 Treg, Tr1, and not excluding BM, apoptotic cell-based strategies), identification/validation of clinical tolerance strategy and biomarkers. Finally, we will also cover B cell immunobiology in transplantation and strategies for B cell and plasma cell tolerance. The special issue will also be open to any author, but mainly invited by guest editor. Each submission will be reviewed by at least two reviewers to ensure a very high quality of papers selected for the Special Issue.

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (transplantation@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

Welcome your submission!


Open Access Review

Antibody-Based Preparative Regimens for Cell, Tissue and Organ Transplantation

Received: 24 November 2021;  Published: 08 July 2022;  doi: 10.21926/obm.transplant.2203162


The ability to successfully transplant cells and organs from a donor into an immunologically disparate recipient is one of the greatest treatment advances in the history of medicine. Nevertheless, acute and chronic rejection, graft versus host disease, and the inability to identify suitable donors continue to be challenges and limit broader [...]
Open Access Review

Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance

Received: 09 May 2019;  Published: 10 March 2020;  doi: 10.21926/obm.transplant.2001104


Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize “for the discovery of acquired immunologic tolerance” and eventually made organ transplantation a reality. However, at the time of his early work in toleran [...]
Open Access Review

Benefits of Combined Liver Transplant: Protection or Tolerance?

Received: 18 April 2019;  Published: 04 September 2019;  doi: 10.21926/obm.transplant.1903084


The privileged liver by its immunological status is described as a tolerogenic organ. However, these alone do not explain the installation of a tolerance after single or combined liver transplantation (kidney, heart, pancreas, intestine). Other factors appear to be involved in the identification of patients likely to be tolerant to their graft [...]
Open Access Review

Induction of Tolerance towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models

Received: 23 November 2018;  Published: 23 August 2019;  doi: 10.21926/obm.transplant.1903080


Background: The application of hematopoietic cell transplantation for induction of immune tolerance has been limited by toxicities associated with conditioning regimens and to graft-versus-host disease (GVHD). Decades of animal studies have culminated into sufficient control of these two problems, making immune tolerance a viable alternative [...]
Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Received: 05 November 2018;  Published: 27 June 2019;  doi: 10.21926/obm.transplant.1902070


In recent years, the potential of hematopoietic stem cells, regulatory T-cells and mesenchymal stem cells resulted in a variety of clinical tolerance trials. Every approach has yielded promising results. However, the riddle of transplant tolerance has not been solved as of yet. The results of the ongoing trials in this field will provide addit [...]
Open Access Review

Innate Immune Determinants of Graft-Versus-Host Disease and Bidirectional Immune Tolerance in Allogeneic Transplantation

Received: 29 September 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901044


The success of organ and tissue transplantation from a healthy donor to a disease individual (allo-­‐ transplantation) is regulated via the immune systems of donor and recipient. To minimize deleterious immune reactivity between donor and recipient, the major obstacle in transplantation is to find a genetic match. Developin [...]
Open Access Review

Cell based Therapy in Transplantation

Received: 10 October 2018;  Published: 13 December 2018;  doi: 10.21926/obm.transplant.1804031


One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive therapies must be the development of a low-side [...]
Open Access Review

Allogeneic Hematopoietic Cell Therapies to Induce Tolerance in Kidney Transplantation

Received: 29 October 2018;  Published: 20 November 2018;  doi: 10.21926/obm.transplant.1804027


In this review, we summarized the latest results from the interventional clinical trials on inducing clinical tolerance in the recipients of human leukocyte antigen (HLA)-matched or mismatched living donor kidney transplantation via establishment of either transient or durable donor chimerism by hematopoietic stem cell (HSC)-based cell therapi [...]
Open Access Review

The Concerted Action of Multiple Mechanisms to Induce and Sustain Transplant Tolerance

Received: 25 September 2018;  Published: 09 November 2018;  doi: 10.21926/obm.transplant.1804025


Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in the induction and maintenance phases of [...]
Open Access Opinion

The Holy Grail to Clinical Transplant Tolerance Is Paved with HLA Epitopes

Received: 11 July 2018;  Published: 05 September 2018;  doi: 10.21926/obm.transplant.1803018


The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes