(ISSN 2577-5820)
OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.
We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 8 days from acceptance to publication (median values for papers published in this journal in 2021, 1-2 days of FREE language polishing time is also included in this period).
Special Issue
Human Islets for Diabetes Research and Transplantation
Submission Deadline: March 31, 2019 (Open) Submit Now
Guest Editor
Tatsuya Kin, MD, PhD
Clinical Islet Laboratory, University of Alberta Hospital, 210 College Plaza, 8215-112 St, Edmonton, Alberta, Canada T6G2C8
Research Interests: Islet isolation; islet transplantation
About the Topic
The past decade has seen enormous progress in clinical islet transplantation as a therapy for type 1 diabetes, as well as steady expansion in human islet isolation activity worldwide. Islet isolation centers have been providing human islets for clinical transplantation and for basic research. Thanks to improvement of islet isolation technology and implementation of islet distribution programs, many basic researchers now have access to this valuable resource. In the face of recent recognition that human islets differ in a critical way from nonhuman counterparts, the demand of human islets for basic research is ever increasing and novel findings on human islet biology are accumulating. Also cells derived from human pancreatic tissue have a potential for future development of cellular based therapy for diabetes. The aim of this issue is to serve as a platform to update the current knowledge and recent progress in the basic research utilizing human islets as well as in clinical islet transplantation.
Publication
Estradiol 17-β Induces Pancreatic Beta-Cell Proliferation through Distinct Estrogen Receptors in a Glucose Dependent MannerAbstract Background: Estradiol 17-beta (E2) enhances the function and survival of pancreatic beta-cells but its clinical use has been questioned due to concerns regarding oncogenic potential and feminizing effects in males. The G-protein coupled estrogen receptor (GPER), expressed in pancreatic islets, exhibits estrogenic beta-cell protective effects [...] |
Immunoprotective Encapsulation of Micro-OrgansAbstract Background: Cell encapsulation technology is most likely the ultimate solution for autologous cell therapy based clinical approaches. A key issue when developing a functional encapsulated construct, is to consider not only the nature of the capsule but also how the cells should be incorporated into the capsule in order to minimally compromise [...] |
Our Steps toward Subcutaneous Transplantation of Macro-Encapsulated IsletsAbstract Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, micro-encapsulated islets used in recent clinical trials are not fully retrievable [...] |
Single Cell Transcriptomic Analysis of Pancreatic β Cell Development and Differentiation from Pluripotent Stem CellsAbstract Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represent an ideal tissue for single cell transcripto [...] |
A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injectionby
Ibrahim Fathi
,
Takehiro Imura
,
Kozue Imura
,
Megumi Goto
,
Yasuhiro Igarashi
,
Akiko Inagaki
,
Makiko Kikkawa
,
Fumiko Ono
,
Hiroo Iwata
,
Yohichi Yasunami
and
Masafumi Goto
Abstract BACKGROUND. Current non-human primate diabetic models, namely those induced by total pancreatectomy or streptozotocin (STZ) injection, suffer from several disadvantages, including a long surgical procedure, the need for continual digestive enzyme replacement, and a delayed oral intake after total pancreatectomy and severe hypoglycemia and [...] |
The DPP4 Inhibitor Sitagliptin Increases Active GLP-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to TransplantationAbstract Background
One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have been reported to maintain cell mass [...] |
Human Islet Isolation and Distribution Efforts for Clinical and Basic ResearchAbstract The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understanding human islet biology and consequently [...] |
Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolationby
Gopalakrishnan Loganathan
,
Michael G. Hughes
,
Gregory L. Szot
,
Kate E. Smith
and
Appakalai N. Balamurugan
Abstract Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for translational research or pre-clinical studies [...] |
Pancreatic Islet Transplantation: State of the Art and Future PerspectivesAbstract Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe hypoglycaemia events and impaired awareness [...] |
Islet Autotransplantations for Total PancreatectomyAbstract Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease like chronic pancreatitis or pancreatic injury. However, it always abolishes the pancreatic exo- and endocrine functions and the nutritional condition of the patients is significantly impaired. Thus, especially in the case of benign diseas [...] |
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