An Approach to Fungal Diagnostics in Solid Organ Transplantation


Abstract
Volume 2,Issue 4
An Approach to Fungal Diagnostics in Solid Organ Transplantationby
![]() ![]() Abstract The approach to diagnosing fungal infections following solid organ transplantation (SOT) is patient-specific. An assessment of an individual’s risk for particular infections, also understood as the pre-test probability, should guide appropriate diagnostic testing whereas diagnostic stewardship is ne [...] |
Chemical Strategies for Improving Islet Transplant Outcomesby
Abstract Islet transplantation has proven to be a viable treatment for individuals suffering from both Type 1 Diabetes Mellitus (T1D) and chronic pancreatitis. However, a variety of challenges limit the effectiveness of this procedure by reducing the number of islets that survive the harvesting and transplan [...] |
Strongyloidiasis in Solid Organ Transplantationby
![]() ![]() Abstract Strongyloides stercoralis, an intestinal parasitic nematode (roundworm), infects more than 100 million people worldwide. While most infected immunocompetent persons are either asymptomatic or experience only mild, intermittent symptoms, immunosuppressed individuals, including those undergoing solid [...] |
Application of Microfluidic Biochips for Human Islet TransplantationAbstract In this review, we discuss the application of microfluidic devices in studying the physiology and pathophysiology of human islets and beta-cells, especially its application for human islet transplantation. Human islet transplantation is a promising therapy for Type I diabetes; however, the islet tra [...] |
Alpha-1 Antitrypsin Deficiency and Lung Transplantation: A Clinical Caseby
![]() ![]() ![]() ![]() ![]() ![]() Abstract BACKGROUND: α1-antitrypsin deficiency is the most common hereditary disorder in adults and is associated to an increased risk of developing lung emphysema. METHODS: With this case report, we describe the case of a 54 years old patient, who underwent bilateral lung transplantation due to alpha-1 anti [...] |
Changes in HLA-G Expression by Leucocyte Subsets Following Renal Transplantation and the Effect of Immunosuppressive Drugs on Leucocyte HLA-G Expression in Vitroby
![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract Background HLA-G is an immunosuppressive molecule with a potential role in allograft acceptance. Methods Expression of HLA-G on leucocyte subpopulations was studied in a group of 21 renal transplant patients immediately prior to and 2 month post-transplantation. Results Significant increases in prop [...] |
Cell based Therapy in TransplantationAbstract One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive ther [...] |
Severe Passenger Lymphocyte Syndrome and Acute Rejection in ABO Compatible but non-Identical Liver Transplant Recipient from Hepatitis C Viremic Donorby
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract We report a burdensome case of transplantation of a HCV-viremic liver graft into a HCV-viremic recipient with minor AB0 mismatch. |
The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunctionby
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract The long term clinical significance of respiratory infections after lung transplantation remains uncertain. In this retrospective single-center cohort study of 441 lung transplant recipients, we formally evaluate the association between respiratory infection and chronic lung allograft dysfunction (C [...] |
Identifying Novel Biomarkers of Frailty in Cirrhosis: Results from an Unbiased Proteomics Search from the Functional Assessment in Liver Transplantation (FrAILT) StudyAbstract BACKGROUND: Patients with cirrhosis suffer not only from commonly-diagnosed portal hypertensive complications such as ascites and hepatic encephalopathy but also from more insidious effects of chronic liver failure including muscle wasting, under-nutrition, and functional decline. These manifestatio [...] |
Allogeneic Hematopoietic Cell Therapies to Induce Tolerance in Kidney TransplantationAbstract In this review, we summarized the latest results from the interventional clinical trials on inducing clinical tolerance in the recipients of human leukocyte antigen (HLA)-matched or mismatched living donor kidney transplantation via establishment of either transient or durable donor chimerism by hem [...] |
The Conundrum of High Body Mass Index in Kidney Transplant PatientsAbstract Obesity is on the rise and the number of end stage renal disease patients who are obese parallel this trend. There is no universally accepted guideline for wait-listing end stage renal disease obese patients in order to reduce short-term complications and improve long-term survival of the kidney gra [...] |
The Concerted Action of Multiple Mechanisms to Induce and Sustain Transplant Toleranceby
![]() ![]() Abstract Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in [...] |
Evolution of Enzyme Requirements for Human Islet IsolationAbstract Islet transplantation is becoming an established treatment option for managing a subset of adult patients who have type 1 diabetes mellitus. The success of this procedure is dependent upon the recovery of a sufficient number of functional human islets from donor organs for subsequent transplant. Her [...] |
Bacterial Infections after Liver Transplantation: Updates in Post-Surgical Infections, Vancomycin-Resistant Enterococcus, and Multi-Drug Resistant EnterobacteriaceaeAbstract Liver transplantation is a life-saving procedure available worldwide. Despite advances in its surgical and immunosuppressive strategies, infectious complications carry significant morbidity and mortality. Bacterial infections are the most common infective etiologies, and the majority are seen during [...] |
Early Nutrition during Critical Illness in Pediatric Patients Post-Hematopoietic Cell TransplantationAbstract Background: Hematopoietic cell transplant (HCT) patients are a high-risk population for poor nutrition and decreased survival. There is little data on how nutrition in pediatric HCT patients affects need for critical care interventions and outcomes. Methods: We hypothesized that patients who did not [...] |
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