Table of Content

Open Access Case Report

Checkpoint Inhibition Followed by CAR-T Cell Therapy in Refractory PMLBCL: Immunologic Response and Fertility Preservation in a Young Patient

Received: 22 February 2025;  Published: 18 June 2025;  doi: 10.21926/obm.transplant.2502253

Abstract

Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive B-cell malignancy that may exhibit resistance to standard chemoimmunotherapy. Novel immunotherapeutic strategies, including checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapy, are being explored in cases that are refractory to treatment. We report the case of a 29-year-old patient with refractory PMLBCL who was treated with pembrolizumab as a bridging therapy followed by axicabtagene ciloleucel (CAR-T) after failing R-CHOP a [...]

729 3574

Open Access Case Report

Mindfulness Training to Reduce Anxiety in Socially Isolated Individuals with Schizophrenia: A Case Study

Received: 17 May 2025;  Published: 15 September 2025;  doi: 10.21926/obm.neurobiol.2503301

Abstract

This article aims to evaluate the impact of mindfulness training on Mr. A, a 17-year-old adolescent with schizophrenia experiencing social isolation and severe anxiety. The subject, Mr. A, is a 17-year-old male who presented with significant anxiety symptoms, including excessive worry, restlessness, difficulty concentrating, irritability, heart palpitations, rapid breathing, and sleep disturbances. These symptoms were accompanied by behaviors of social withdrawal, emotional detachment, and reluctance to communicate [...]

754 3537

Open Access Original Research

Effects of Plastoquinone Derivative 10-(6'-Plastoquinonyl) Decyltriphenylphosphonium on Rice Seeds Grown under Complete Flooding Conditions

Received: 20 February 2025;  Published: 22 July 2025;  doi: 10.21926/obm.genet.2503305

Abstract

The present work aimed to study the effects of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on rice (Oryza sativa) plants germinating under flooding conditions. The influence of different concentrations of SkQ1 (mitochondria-targeted antioxidant) on resistance to complete flooding was assessed on rice seedlings of the Kuboyar variety. The total level of reactive oxygen species (ROS), H2O2-induced chemiluminescence, and gene expression of antioxidant enzymes (OsSODA (superoxide dismutase A), OsSODB (s [...]

716 3495

Open Access Perspective

Performance Art as Lifestyle: Art in Action for Health Promotion

Received: 11 May 2025;  Published: 28 July 2025;  doi: 10.21926/obm.icm.2503033

Abstract

Performance art is both a visual arts practice and kinaesthetic approach to place-based health. The perspective of this commentary is to promote the attributes of performance art to showcase its capacity to extend people into new configurations of cultural engagement with beneficial effects. Performance art is an opportunity to engage both mind and body in actions that transform predictability and encourage wellness within the context of people’s life studios (their everyday lives). Wellness is defined here in rela [...]

560 3475

Open Access Review

The Essentials of Cell-Mediated Immunity Assays for the Management of CMV Infection after Solid Organ Transplantation

Received: 12 March 2025;  Published: 04 September 2025;  doi: 10.21926/obm.transplant.2503256

Abstract

Provided that cell-mediated immunity (CMI) is known to be vital in managing CMV infection post-transplant along with improving methods to predict the development of cytomegalovirus (CMV) following transplant, CMV-specific-cell-mediated immunoassays have been developed, commercially and research based, to be used in conjunction with pre-transplant CMV serological testing and prophylaxis to help tailor an individual care plan post-transplant. In this review, we assess the status of CMV CMI assays, and their potential [...]

646 3456

Open Access Case Report

Art of Telesupport of Caregiver during Myasthenia Gravis Crisis by COVID-19 Infection-Related Followed by Rescue in Late-Onset Patient

Received: 06 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.icm.2402035

Abstract

An 83-year-old man with myasthenia gravis was hospitalized in the ICU; support for caregivers of elderly myasthenic patients in the ICU can be a crucial aspect of their care. Myasthenia gravis is a chronic autoimmune neuromuscular disease that can cause varying levels of muscle weakness, which can significantly impact the patient's day-to-day activities and overall quality of life. This intervention was followed for over one month with success. The critical phases are presented and analyzed as a medical support art [...]

775 3455

Open Access Research Article

Motivation to Cultivate Social Ties and Diurnal Cortisol: Testing the Mediating Effect of Social Embeddedness in Chinese Older Adults

Received: 20 July 2024;  Published: 02 March 2025;  doi: 10.21926/obm.geriatr.2501300

Abstract

Based on a framework derived from theories of social integration and health, this study examined the relationships between motivation to cultivate social ties or network cultivation, and diurnal salivary cortisol in Chinese older adults. The main objective was to determine the behavioral mechanism that translated a higher motivation to cultivate social ties into healthier diurnal cortisol rhythms in 82 community-dwelling elders in Shanghai. Participants were provided four saliva samples immediately, 30 minutes, and [...]

797 3448

Open Access Original Research

Bioremediation of Organic Compounds and Trace Metals from Landfill Leachate Using Lactobacillus kefiri Strains: A Sustainable Approach Based on Facultative Treatment

Received: 09 November 2023;  Published: 16 September 2025;  doi: 10.21926/rpm.2503014

Abstract

The sustainable management of water resources is increasingly recognized as a critical component of environmental conservation and socio-economic development. Among the most challenging aspects of wastewater treatment is the effective remediation of landfill leachate, a complex and highly polluted effluent characterized by high levels of organic matter, ammonia, turbidity, and heavy metals. This study investigates an integrated treatment approach that combines chemical coagulation using aluminum sulfate with a subs [...]

684 3440

Open Access Case Report

The Homozygous c.612C>G Mutation in C1QBP is Associated with Late-Onset Progressive External Ophthalmoplegia

Received: 30 November 2024;  Published: 04 September 2025;  doi: 10.21926/obm.genet.2503309

Abstract

Biallelic pathogenic variants in C1QBP are an infrequent, yet increasingly recognised, cause of progressive external ophthalmoplegia (PEO). Although most published cases include cardiomyopathy, isolated late‑onset PEO without cardiac disease remains exceptional. To characterise, for the first time, a Moldavian‑Ukrainian pedigree in which homozygous c.612C>G (p.Phe204Leu) in C1QBP causes autosomal‑recessive PEO in the absence of cardiomyopathy, thereby expanding the phenotypic spectrum of C1QBP‑related disease. W [...]

638 3409

Open Access Original Research

Evaluation of Polylocus Spectra of DNA Fragments of the Genus Eguus Using ISSR-PCR Markers

Received: 16 April 2025;  Published: 07 July 2025;  doi: 10.21926/obm.genet.2503302

Abstract

Characterization of the non-coding part of the transcriptome is a supplement to the annotation of the genome of living organisms. According to ISSR-fingerprinting data, information is obtained about ancient gene pools, modern gene pools, genetic variability and conservation of breeds and species of farm animals. The aim of the study is to study the molecular genetic component and phylogenetic relationships in the aboriginal Hutsul horse breed and fossil remains of ancient horses using ISSR-PCR markers. The polymorp [...]

698 3400

Open Access Editorial

Neuroinflammation in Chronic Pain, Treatment with Topical and Nontraditional Therapies

Received: 09 February 2025;  Published: 10 February 2025;  doi: 10.21926/obm.icm.2501010

Abstract

Medicines used in pain and chronic pain are aimed at relieving neuroinflammation. This neuroinflammation can occur in the brain, brain stem, dorsal root ganglion and other sites. What causes neuroinflammation? Why does this neuroinflammation last for years? Are there cures for neuroinflammation?

628 3395

Open Access Concept Paper

Toward a Unifying Transcultural Perspective on Illness, Health and Wellbeing: A Theoretical Proposition

Received: 04 March 2025;  Published: 11 September 2025;  doi: 10.21926/obm.icm.2503038

Abstract

This paper presents a unifying transcultural perspective on human illness, health and wellbeing by integrating insights from cognitive psychology, existential psychotherapy, Zen philosophy, Traditional Chinese Medicine (TCM), and quantum consciousness theory. Kahneman and Tversky’s work on heuristics and biases highlights cognitive constraints shaping decision-making, while Yalom’s existential therapy explores fundamental struggles with death, freedom, and meaning. Watts’ Zen philosophy critiques the illusion of eg [...]

832 3386

Open Access Research Article

Embracing Time: The (Dis)Comfort of Life After Allogeneic Stem Cell Transplants

Received: 19 September 2024;  Published: 06 February 2025;  doi: 10.21926/obm.transplant.2501233

Abstract

Allogeneic Stem Cells Transplantation (ASCT) and, consequently, the chronicity associated with this life event has a growing prevalence and a significant impact on the life and daily life of each person who experiences it. The growing number of ASCT survivors highlights the need to reflect on the unique challenges they face throughout their recovery. To understand the meaning of the encounter with time in the lived experience of comfort for survivors of ASCT. Qualitative approach using van Manen's phenomenology of [...]

584 3385

Open Access Original Research

Protective Effects of Teucrium polium Extract Against LPS-Induced Oxidative Stress in BV-2 Microglia: Insights from Wild-Type and Acox1⁻/⁻ Models

Received: 20 May 2025;  Published: 30 July 2025;  doi: 10.21926/obm.neurobiol.2503293

Abstract

Microglial activation and the associated oxidative or inflammatory responses play a crucial role in the development of neurodegenerative diseases. In this study, we evaluated the antioxidant, cytotoxic, and anti-inflammatory properties of Teucrium polium (TP) ethanolic extract in murine BV-2 microglial cells, including wild-type (Wt) and peroxisomal β-oxidation-deficient Acox1-/- cell lines. The TP extract exhibited high antioxidant activity as assessed via the DPPH test, with an IC50 value of 73.89 μ [...]

601 3376

Open Access Editorial

Acknowledgment to Reviewers of Recent Progress in Materials in 2024

Received: 02 January 2025;  Published: 02 January 2025;  doi: 10.21926/rpm.2501001

Abstract

The editors of Recent Progress in Materials would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up t [...]

695 3356

Open Access Original Research

The Influence of Gender and Academic Achievement on University Students' Perceptions of LMS-Based Self-Regulated Learning in Korea

Received: 28 April 2025;  Published: 09 October 2025;  doi: 10.21926/obm.neurobiol.2504304

Abstract

This study examines how university students perceive Learning Management System (LMS)-based instruction within the context of higher education, as they adapt to the rapid digital transformation. Specifically, it examines how students' perceptions differ based on gender and academic achievement, providing insights for more inclusive and adaptive instructional design. LMS platforms, when actively utilized, offer more than just content delivery—they can enhance classroom transparency, provide immediate feedback, promo [...]

700 3352

Open Access Review

Neurobiology of Cancer Pain: A Narrative Review

Received: 10 September 2025;  Published: 12 December 2025;  doi: 10.21926/obm.neurobiol.2504315

Abstract

Chronic cancer pain results from the complex interaction of nociceptive, neuropathic, and neuroimmune mechanisms, which vary according to tumor type, location, stage, and treatment history. Recent advances in cancer neuroscience have reframed pain as a dynamic manifestation of reciprocal tumor–nerve–immune interactions, rather than a mere consequence of tissue damage. In this model, malignant, stromal, and immune cells remodel nociceptive circuits at peripheral and central levels. This narrative review, conducted i [...]

1236 3322

Open Access Original Research

A Pilot Study Testing the Clinical Congruency of Healthcare Providers to Use a Clinical Decision Support Tool to Assess Falls in Older Adults

Received: 30 January 2024;  Published: 10 March 2025;  doi: 10.21926/obm.geriatr.2501303

Abstract

This research sought to determine feasibility for RNs to use the Post Fall Index™ (PFI) and to determine if an RN could identify underlying causal event factors for falls, would it be congruent with other providers (advanced practice nurse [APN], physician [MD])? PFI data from 23 falling residents of a nursing home were compiled into clinical vignettes and reviewed by experts for underlying causal event factors/fall sub-types. RNs used the PFI for one month in practice. The RN generated the most diagnoses; pe [...]

635 3321

Open Access Editorial

Acknowledgment to Reviewers of Recent Progress in Nutrition in 2024

Received: 02 January 2025;  Published: 02 January 2025;  doi: 10.21926/rpn.2501001

Abstract

The editors of Recent Progress in Nutrition would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up t [...]

615 3252

Open Access Short Report

Donor-Derived Cell-Free DNA Assessment in a Predominantly Hispanic/Latino Lung Transplant Population: Single-Center Analysis

Received: 31 March 2025;  Published: 21 July 2025;  doi: 10.21926/obm.transplant.2503254

Abstract

The demographics of lung transplant (LT) recipients show an evolution towards increased minority racial/ethnic representation, thanks to an increased focus on inclusion in LT access, healthcare and outcomes. Herein we assess potential differences in LT allograft health in a predominantly Hispanic/Latino (HL) vs Non-Latino/White (NLW) cohort during surveillance for acute rejection by analyzing the fraction of donor-derived cell-free DNA (dd-cfDNA%), a plasma biomarker of allograft injury. Of 245 LT recipients, media [...]

673 3213

Open Access Research Article

Opportunities, Dilemmas, and Limitations in Applying "Healthy Living" and "Aging in Place" in Designs for New Housing Concepts in Dutch Neighborhoods

Received: 23 March 2025;  Published: 19 November 2025;  doi: 10.21926/obm.geriatr.2504331

Abstract

This article explores the ongoing work associated with the masterclasses "Towards an Inclusive Living Environment." It critically examines the concept of healthy living for all and aging in place by studying neighborhoods within Dutch cities. The article argues that creating inclusive, healthy environments fosters well-being and promotes a lifestyle of health and autonomy for all. Next to literature studies, we worked with our students in different neighborhoods of The Hague, conducting ethnographic research. Throu [...]

756 3208

Open Access Editorial

Acupuncture in Gynecology and Assisted Reproduction – A Short Evidence-Based Review

Received: 08 December 2025;  Published: 09 December 2025;  doi: 10.21926/obm.icm.2504053

Abstract

Acupuncture has become an increasingly relevant complementary modality in modern gynecology and assisted reproduction. Its uses include the management of menstrual disorders, menopausal symptoms, infertility, polycystic ovary syndrome (PCOS), endometriosis, and others. Scientific progress in neurophysiology, laser acupuncture, and biomedical imaging has enabled a deeper understanding of the central and peripheral mechanisms underlying acupuncture’s effects. This editorial summarizes current evidence regarding physi [...]

802 3172

Open Access Original Research

Preliminary Comparative Sodium Analysis of Different Tempeh Types in Indonesia and Its Benefits for Hemodialysis

Received: 01 April 2025;  Published: 19 September 2025;  doi: 10.21926/rpn.2503020

Abstract

Hemodialysis patients require a diet rich in protein that is easily digestible, such as tempeh. Tempeh is a local Indonesian food product that can be purchased at a low price. Tempeh has a low sodium content, but there has never been an analysis related to the difference in sodium content in local Indonesian soybean tempeh products and imported soybean tempeh. This study was to compare the sodium analysis of different tempeh types in Indonesia as a preliminary study for the subsequent research to fulfill a high-pro [...]

608 3152

Open Access Research Article

“More Attentive to My Wellness”: Reported Experiences of Academic Nurse Faculty and Staff in the Early Months of the Pandemic

Received: 02 July 2024;  Published: 26 January 2025;  doi: 10.21926/obm.icm.2501008

Abstract

The COVID-19 pandemic presented major changes for individuals working in nursing academia. While university faculty and staff encountered many challenges, the pandemic also presented new opportunities. The purpose of this study was to determine how the early months of the COVID-19 pandemic impacted nursing faculty and staff perceptions about their wellness experiences. An on-line survey was developed and sent to all faculty and staff. Data were collected through a convenience sample using both open-ended and closed [...]

614 3148

Open Access Research Article

Potential Synergistic Interaction Between Curcumin and Sorafenib Enhances Cytotoxicity in NCI-H5222 Lung Cancer Cells

Received: 25 August 2025;  Published: 15 October 2025;  doi: 10.21926/obm.genet.2504313

Abstract

Non-small cell lung cancer (NSCLC), accounting for approximately 85% of lung cancer cases, remains a leading cause of cancer-related mortality. Genetic alteration such as EGFR mutations, tobacco exposure, and resistance to apoptosis, slows its progression and limits therapeutic success. Although targeted therapies and immunotherapy have improved outcomes for select patients, resistance remains a major challenge, highlighting the need for more effective treatments. This study investigated the potential synergistic i [...]

703 3137

Open Access Original Research

An Exploration of the Experiences of Group Compassion Focused Therapy for Hospital Outpatients with Long-Term Mental Health Difficulties

Received: 07 April 2025;  Published: 12 January 2026;  doi: 10.21926/obm.icm.2601005

Abstract

There is now good evidence for the efficacy of Compassion Focused Therapy (CFT) for a variety of mental health difficulties. To deepen understanding of the processes underpinning CFT’s effectiveness, this service evaluation explored the experiences and reflections of individuals with long-term mental health difficulties who had previously received therapy and attended an 11-week CFT group. Ten clients were invited to the group; one withdrew before the group started because of work and personal commitments and anoth [...]

1798 3129

Open Access Editorial

The Next Frontier in Photocatalytic Hydrogen Generation

Received: 24 October 2025;  Published: 03 November 2025;  doi: 10.21926/cr.2504008

1043 3125

Open Access Case Report

Netherton Syndrome in a 9-Month-Old Child: Unraveling a Complex Dermatologic Disorder

Received: 05 June 2025;  Published: 15 September 2025;  doi: 10.21926/obm.genet.2503311

Abstract

Netherton syndrome is a rare autosomal recessive disorder caused by mutations in the SPINK5 gene, leading to LEKTI protein dysfunction, impaired skin barrier function, and immune dysregulation. It manifests as a triad of ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), and atopic diathesis, often mimicking other inflammatory dermatoses. We report a 9-month-old Javanese Indonesian male infant presenting with extensive erythematous, scaly skin lesions and severe pruritus. Laboratory tests revealed [...]

620 3098

Open Access Review

Medical Digital Technologies in Older Patients with Cardiac Disease Achievements and Drawbacks

Received: 17 February 2025;  Published: 09 September 2025;  doi: 10.21926/obm.geriatr.2503323

Abstract

Older adults are a growing population characterized by a high prevalence of multimorbidity and age-related conditions, such as organ and pharmacokinetic dysfunction. Medical digital technologies have emerged through the combined use of wearable, implantable, and insertable medical devices with digital systems. Gerontology aims to help older patients with disabilities utilize these technologies. These technologies are used in high-tech medical centers, particularly among older cardiac patients. Many cardiac societie [...]

713 3067

Open Access Original Research

Investigating Associations between Maternal Mindfulness, Mental Health, Interoception and Mother-Infant Relationship during Pregnancy and Post-Partum in a Non-Clinical Community Sample

Received: 21 May 2025;  Published: 26 October 2025;  doi: 10.21926/obm.icm.2504046

Abstract

Pregnancy and the postpartum period are times of significant transition for women, with changes in maternal physical and mental health. The relationship between a mother and her infant has been recognised as laying the foundation for later child development. There is considerable evidence that this early relationship is influenced by a woman’s wellbeing during pregnancy and in the early post-partum period. Mindfulness has been found to have positive health outcomes, primarily in reducing maternal stress, anxiety, a [...]

748 3007

Open Access Review

Pharmacological Strategies to Enhance Bone Graft Integration: Emerging Agents and Molecular Pathways

Received: 15 May 2025;  Published: 31 December 2025;  doi: 10.21926/obm.transplant.2504262

Abstract

Bone grafting remains a cornerstone technique in orthopedic and reconstructive surgery, yet achieving successful graft integration continues to pose significant challenges, particularly in conditions such as osteoporosis, diabetes mellitus, and large bone defects. Traditional graft materials such as autografts, allografts, xenografts, and synthetics, often encounter limitations including immune rejection, poor vascularization, and insufficient osteogenic support. Emerging pharmacological strategies have shown promi [...]

1340 2986

Open Access Editorial

Acknowledgment to Reviewers of Advances in Environmental and Engineering Research in 2024

Received: 02 January 2025;  Published: 02 January 2025;  doi: 10.21926/aeer.2501002

Abstract

The editors of Advances in Environmental and Engineering Research would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, r [...]

543 2979

Open Access Review

Maladjustment in Minority Youth from Community Network Disparities in the COVID-19 Lockdown Environment

Received: 17 April 2024;  Published: 04 August 2025;  doi: 10.21926/obm.neurobiol.2503295

Abstract

Pandemic lockdown orders resulted in closures to critical community networks. One such infrastructure was community recreation centers/parks. This infrastructure serves a critical role in building psychosocial wellness for youth. Socioeconomic minority youth face baseline disparity in center/park distribution and services. Youth recreation activity declined 50% as result of lockdown orders with corresponding decline in youth mental health status. Despite overall youth activity decline, White and high socioeconomic [...]

556 2952

Open Access Original Research

Fabrication of CuO-Decorated Fe2O3 Nanoparticles as Efficient and Durable Electrocatalyst for Oxygen Evolution Reaction

Received: 09 August 2025;  Published: 07 November 2025;  doi: 10.21926/cr.2504009

Abstract

The electrochemical water oxidation application of CuO@Fe2O3 materials as potential catalysts is being reported for the first time. A series of CuO@Fe2O3 with different molar ratios of CuO (5, 7, 10, 12, and 15%) was fabricated through precipitation followed by the impregnation method. Structural and electrochemical studies were carried out by using different analytical platforms, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Energy dispersive [...]

919 2869

Open Access Case Report

Nursing Care for a Patient with a Risk of Suicide Due to Depression Using the Solution-Focused Brief Therapy Approach: Case Study

Received: 11 September 2025;  Published: 17 November 2025;  doi: 10.21926/obm.neurobiol.2504309

Abstract

Adolescent depression is linked to suicidal ideation and attempts. Nurses are well-positioned to deliver brief, supportive interventions. Solution-Focused Brief Therapy (SFBT) emphasizes solutions and the activation of personal resources. To describe the feasibility and clinical utility of SFBT, delivered alongside pharmacotherapy, for reducing suicide risk in an adolescent with depression. Single-case report using a nursing process approach in a 17-year-old female inpatient with a major depressive episode and high [...]

468 2842

Open Access Original Research

Deep Learning Approaches for Predicting Strain Energy in Heterogeneous Materials

Received: 15 July 2025;  Published: 24 October 2025;  doi: 10.21926/rpm.2504016

Abstract

This paper investigates data-driven strain energy prediction for heterogeneous elastic materials using the Mechanical MNIST benchmark dataset (60,000 28 × 28 stiffness maps by precomputed finite-element results). The results by classical regression models (linear regression, random forest, and gradient boosting) using hand-crafted features were compared with the results by the deep learning models (Convolutional neural network (CNN) and residual network (ResNet)) trained end-to-end on images. In held-out tests, CNN [...]

755 2777

Open Access Editorial

Acknowledgment to Reviewers of OBM Genetics in 2024

Received: 03 January 2025;  Published: 03 January 2025;  doi: 10.21926/obm.genet.2501277

Abstract

The editors of OBM Genetics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of Sci [...]

622 2771

Open Access Interview

An Interview with Prof. Dr. Roy G. Beran

Received: 27 April 2025;  Published: 28 April 2025;  doi: 10.21926/obm.geriatr.2502310

579 2750

Open Access Original Research

Network Topology Similarities Across Cancer Types: Identifying Central Protein Hubs for Drug Discovery

Received: 18 June 2025;  Published: 13 October 2025;  doi: 10.21926/obm.genet.2504312

Abstract

A molecular-level understanding of cancer is essential for the development of effective therapies. Constructing protein-protein interaction (PPI) networks offers a valuable approach to identifying dysregulated driver genes and potential therapeutic targets. In this study, we modeled cancer PPI networks as metric spaces and applied mathematical and computational algorithms to analyze their structural and functional properties. Our findings reveal that these networks share a conserved architecture across different ca [...]

661 2706

Open Access Original Research

Evaluation of the Transitional Pain Service Specialized Iyengar-Informed Yoga Program for Chronic Post-Surgical Pain: A Pilot Randomized Controlled Trial

Received: 29 April 2025;  Published: 30 September 2025;  doi: 10.21926/obm.icm.2503041

Abstract

The objective of this randomized controlled trial (RCT) was to evaluate the feasibility and efficacy of a specialized Iyengar-informed yoga intervention for individuals who experience chronic post-surgical pain (CPSP). This prospective, multi-wave pilot RCT was pre-registered at clinicaltrials.gov (NCT03460028) and designed in accordance with the 2010 CONSORT statement. Participants (N = 21) with CPSP were out-patients or community members affiliated with a Toronto hospital. Participants were randomized to an 8-wee [...]

709 2696

Open Access Original Research

The Effect of Adding Mealworm, Probiotics, and Mealworm Plus Probiotics on IL-8 Gene Expression in Liver and Spleen Tissues of Broiler Chickens

Received: 30 July 2025;  Published: 30 October 2025;  doi: 10.21926/obm.genet.2504315

Abstract

Interleukin-8 (IL-8), a pro-inflammatory cytokine, plays a critical role in immune modulation in poultry and has potential applications in veterinary and human medicine. This study investigated the effects of dietary supplementation with mealworm (Tenebrio molitor), probiotics, or their combination on IL-8 gene expression in the livers and spleens of broiler chickens. A total of 160 one-day-old broiler chickens (Ross 308 strain) were assigned to four treatments (basal diet, basal diet + 0.2 g/kg probiotic, basal di [...]

641 2685

Open Access Interview

An Interview with Prof. Andrew S Day

Received: 24 February 2025;  Published: 25 February 2025;  doi: 10.21926/rpn.2501003

596 2675

Open Access Original Research

Occurrence of Multidrug Resistant Escherichia coli & Escherichia coli O157:H7 in Raw Cow Milk from Dhaka, Bangladesh

Received: 01 May 2025;  Published: 09 December 2025;  doi: 10.21926/rpn.2504025

Abstract

Enteropathogenic strains of Escherichia coli, like the serotype O157:H7, can cause significant health issues if consumed. Milk and dairy products can serve as a reservoir for the bacteria. Dissemination of multidrug-resistant E. coli through dairy products can become a potential health hazard if consumed. The present study investigates the occurrence of multidrug-resistant E. coli O157:H7 in raw milk obtained from farms and markets around Dhaka, Bangladesh. A Total of 50 milk samples were collected in this study fr [...]

797 2657

Open Access Review

Healthy Ageing and its Communal Nemesis Social Frailty

Received: 11 June 2025;  Published: 29 October 2025;  doi: 10.21926/obm.icm.2504047

Abstract

Across the globe, countries are facing an ageing boom, with the proportion of the older adult population growing compared to younger age groups because of increased life expectancy and declining birth rates. Along with the ageing boom, there is increased interest in the wellbeing of older adults. Healthy ageing and social frailty are two constructs that have emerged in studying older adults and their quality of life. In this paper, we critically review salient literature defining and describing healthy ageing and s [...]

712 2635

Open Access Interview

An Interview with Prof. Dr. Hanuman Singh Jatav

Received: 26 October 2025;  Published: 27 October 2025;  doi: 10.21926/aeer.2504030

494 2600

Open Access Editorial

Acknowledgment to Reviewers of OBM Integrative and Complementary Medicine in 2024

Received: 03 January 2025;  Published: 03 January 2025;  doi: 10.21926/obm.icm.2501001

Abstract

The editors of OBM Integrative and Complementary Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, revie [...]

516 2596

Open Access Editorial

Acknowledgment to Reviewers of OBM Neurobiology in 2024

Received: 03 January 2025;  Published: 03 January 2025;  doi: 10.21926/obm.neurobiol.2501262

Abstract

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of [...]

506 2580

Open Access Concept Paper

Movement-informed Breathwork (MiB): Integrating Muscular Contractions with Slow Conscious Connected Breathing for Therapeutic Application

Received: 28 July 2025;  Published: 22 January 2026;  doi: 10.21926/obm.icm.2601006

Abstract

This paper introduces Movement-informed Breathwork (MiB), a personalised breath-body approach with biofeedback that integrates a form of conscious connected breathwork (breathing without pauses) with targeted neuromuscular contraction and relaxation cycles. Drawing from neuromuscular torque chain dynamics, fascial research and sensorimotor trauma therapy principles, MiB aims to enhance autonomic regulation, interoceptive awareness and somatic-emotional integration by bridging traditional breathwork (deep, slow-pace [...]

495 2573

Open Access Editorial

Acknowledgement to Reviewers of OBM Transplantation in 2024

Received: 02 January 2025;  Published: 02 January 2025;  doi: 10.21926/obm.transplant.2501229

Abstract

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to t [...]

482 2554

Open Access Editorial

Life Sciences Worldwide – Global Perspectives and Networking for International Professionals1

Received: 15 October 2025;  Published: 16 October 2025;  doi: 10.21926/obm.icm.2504044

Abstract

The International Exchange of Professionals – Thematic Event in Life Science, held on October 15-17, 2025, in Nice, France, inaugurated a global congress series focused on frontier topics in biomedical sciences. This editorial summarizes the first day of the event, including the opening ceremony, keynote forum, and welcome banquet. With more than 150 participants from over 35 countries, the event created a platform for cross-disciplinary exchange and collaboration. Key themes included translational medicine, neurom [...]

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