by Maurizio Salvadori  and Aris Tsalouchos

Received: 13 October 2019;  Published: 02 December 2019;  doi: 10.21926/obm.transplant.1904093

Antibody-mediated rejection represents a significant barrier to favorable long-term outcomes after kidney transplantation and remains the most common cause of allograft failure. Therapeutic apheresis techniques are commonly used, in combination with other treatments such as immunosuppressive drugs, in the pre-transplant and post-transplant protocols for the prevention and treatment of antibody-mediated injury. The rationale is to remove the donor-specific antibodies and the other inflammatory mediators, which inclu [...]

by A. Guillermo Bracamonte

Received: 30 December 2022;  Published: 13 February 2023;  doi: 10.21926/rpm.2301008

In the present work we describe the most important quantum properties of graphene and derivatives recently published. We discuss how these properties were incorporated into varied hybrid materials such as substrates for specific tuning of matter to track varied quantum signals. Their potential applications were analyzed from nanomaterial and nanotechnology. In particular graphene, its derivatives and other carbon-based allotropes were chosen due to their special chemical structure and properties from the nanoscale [...]

by Kerstin Grund  , Dominik Sturm  , Christian Sutter  , Felix Sahm  , Katrin Hinderhofer  , Christian Kratz  , Daniel Schrimpf  , Andreas von Deimling  , Kristian W. Pajtler  , David TW Jones  , Stefan M. Pfister  and Nicola Dikow

Received: 01 September 2017;  Published: 05 December 2017;  doi: 10.21926/obm.genet.1704011

The study “Molecular Neuropathology 2.0” (MNP2.0) offers an integrated histo-molecular diagnosis including the detection of potential therapeutic targets for a large cohort of pediatric patients with primary CNS tumors. After obtaining parental and/or patient consent, in this study germline DNA analysis of all study subjects bridges the gap between scientific genetic analysis and medical care. The study’s workflow takes into consideration the conditions of a multicenter study, legal stipulations, as well as the nee [...]

by Scott S. Graves  , DavidW. Mathes  and Rainer Storb

Received: 23 November 2018;  Published: 23 August 2019;  doi: 10.21926/obm.transplant.1903080

Background: The application of hematopoietic cell transplantation for induction of immune tolerance has been limited by toxicities associated with conditioning regimens and to graft-versus-host disease (GVHD). Decades of animal studies have culminated into sufficient control of these two problems, making immune tolerance a viable alternative to life-long application of immunosuppressive drugs to prevent allograft rejection. Methods: Studies in mice have paved the way for the application of HCT with limited toxicity [...]

by Holly Hazlett-Stevens

Received: 26 July 2021;  Published: 23 November 2021;  doi: 10.21926/obm.icm.2104049

Mindfulness-Based Stress Reduction (MBSR) is an evidence-based health education program for medical patients with a variety of chronic conditions. MBSR also benefits health care providers themselves, decreasing work-related stress and preventing burnout. The objectives of this study were to describe an abbreviated MBSR curriculum developed for health care providers and to present initial program evaluation data assessing acceptability and outcomes. This program was implemented outside the research context with an o [...]

by Suneetha Vallepu  , Khadar Basha Shaik  , Naseem Shaik  , Ramakrishna Vadde  , Narasimhulu Ragimekula  and Shaik Sha Valli Khan Patan

Received: 17 July 2023;  Published: 09 November 2023;  doi: 10.21926/rpn.2304020

The present investigation aims to study the influence of household processing methods, such as soaking, germination, and steam cooking, on nutritional composition (proximates, amino acids, minerals, and vitamins), antinutrient factors (phytochemicals: tannins, total phenols, phytic acid; enzyme inhibitors: trypsin and α-amylase inhibitors) and antioxidant properties of whole grains of foxtail millet. The contents of total ash (1.42%), fat (3.02 g/100 g), and mineral chromium (12.83 mg/100 g) were found to be [...]

by Ray Marks

Received: 25 March 2019;  Published: 28 March 2019;  doi: 10.21926/obm.geriatr.1901042

Depression and Aging: Role of Social Support

by Ganisetti Vijay Kumar  , Min-Ze Lu  and Chang-Ming Liaw

Received: 02 May 2021;  Published: 11 August 2021;  doi: 10.21926/jept.2103037

The development of high-efficiency motor drives for various applications is important in the industry 4.0 era, especially for their extensive application to electric vehicles (EVs). In this study, a position sensorless EV synchronous reluctance motor (SynRM) drive has been developed, which exhibits good driving performance and efficiency over a wide speed and load range. To solve the key problems popularly encountered in the existing approaches, the high-frequency injection (HFI) scheme based on q-axis injection ha [...]

by Sara Schatz  and Melvin Gonzalez Rivera

Received: 15 March 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903069

Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Improved pragmatic competence in patients has been found in patients with Mild Cognitive Impairment (MCI) and early to moderate Alzheimer’s Disease (AD) in the domains of jokes, self-expression and empathy after extended, targeted intranasal insulin therapy. In this paper it is argued that extended intra-nasal insulin treatment can [...]

by Michael Mazzei  , Suresh Keshavamurthy  , Olga Timofeeva  and Yoshiya Toyoda

Received: 11 September 2020;  Published: 04 January 2021;  doi: 10.21926/obm.transplant.2101130

Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means [...]

by Mª Carmen Márquez

Received: 15 September 2023;  Published: 24 January 2024;  doi: 10.21926/rpm.2401002

Organics found in landfill leachate (humic acids, fulvic acids, and hydrophilic fraction) have a solid ability to absorb ultraviolet (UV) radiation, which negatively affects UV disinfection; leachate ultraviolet quenching substances (UVQS) can, therefore, have a significant impact on the cotreatment of landfill leachate and sewage in wastewater treatment plants. On the other hand, per- and polyfluoroalkyl substances (PFAS), which pose potential risks to the environment and human health, commonly exist in landfill l [...]

by Walid AL-ACHKAR  , Manar As’sad  , Thomas Liehr  , Adnan Ikhtiar  and Abdulsamad Wafa

Received: 14 August 2018;  Published: 20 June 2019;  doi: 10.21926/obm.genet.1902081

Background: The aggressive T-cell acute lymphoblastic leukemia (T-ALL) is one of the frequently occurring malignancies of the thymocytes. T-ALL is observed in 15% and 25% of all new diagnosed ALL cases in children and adults, respectively. Notably, T-ALL has a 3-fold higher incidence in males than in females. In nearly half of T-ALL cases, structural and/or numerical chromosomal abnormalities are detected, which have an important prognostic significance. A well-known genetic subtype of B-ALL, high hyperdiploidy (He [...]

by Sierra Day  and Paul D. Loprinzi

Received: 27 April 2019;  Published: 04 July 2019;  doi: 10.21926/obm.icm.1903042

Background: The objective of this study was to evaluate the effects of acute moderate-intensity exercise on autobiographical episodic memory and semantic memory. Methods: A two-arm, parallel-group randomized controlled intervention was employed. The experimental group engaged in an acute bout of treadmill exercise for 15 minutes (70% of heart rate max), while the control group engaged in a time-matched seated activity. For episodic autobiographical memory, participants recalled as many personal memories of events f [...]

by Kristin Shrader-Frechette

Received: 02 June 2022;  Published: 24 August 2022;  doi: 10.21926/aeer.2203032

Scientific data are almost nonexistent regarding the health-protectiveness of most hazardous-waste-site remediation. Given this data-gap, recently the World Health Organization (WHO) urged scientists to develop methods of "cost-efficient health surveillance" of toxics' cleanups, including any "illegal operations". Following WHO, this article's importance is to develop one such cost-efficient method. Given the assumption that remediators'-redevelopers' public misrepresentations of their cleanups' safety may warrant [...]

by Lorraine Cowley  and Mari Jones

Received: 30 December 2019;  Published: 26 April 2020;  doi: 10.21926/obm.genet.2002108

This paper explores views of healthcare professionals (HCPs) in genetics and foetal medicine settings on offering pre-natal diagnosis (PND) for adult onset cancer susceptibility (AOCS) genes. Study participants came from different disciplinary backgrounds and all had considered implications of offering PND for AOCS, directly or indirectly, from professional and personal perspectives. Foetal medicine and genetics teams are accustomed to offering PND with the possibility of terminating an affected foetus on the basis [...]

by Alla V. BALUEVA  , Ilia N. Dashevskiy  and Christian Sims

Received: 18 April 2022;  Published: 30 August 2022;  doi: 10.21926/jept.2203028

Due to the increasing need to further develop the world gas and oil industry and the increased public attention to clean energy sources, studying and preventing Hydrogen Induced Cracking is one of the main safety concerns in nuclear power plants, oil pipelines and platforms. In this article, the growth and incubation times for internal Hydrogen Induced Cracks (HIC) are examined. Specifically, these times are modeled in two separate phases - the first phase (I) is a long time approximation, when the crack growth is [...]

by Lauren Ferguson  , Justin Cantrelle  and Paul Loprinzi

Received: 06 September 2018;  Published: 17 December 2018;  doi: 10.21926/obm.icm.1804034

Background: The present study evaluates the effects of selective directed forgetting (SDF) and directed forgetting (DF) on subsequent memory retrieval and investigate whether acute exercise can facilitate the effects of SDF. Methods: A four-arm (n=20 per group; N=80; Mage=20 yrs), parallel-group, randomized controlled experiment was employed. The four groups included: 1) exercise plus SDF (Ex+SDF), 2) SDF only (SDF), 3) DF only (DF) and 4) R (remember) only (R). Participants viewed two separate word lists (list 1 a [...]

by Katrina McFerran  , Carmen Cheong-Clinch  , Jennifer Bibb  and TanChyuan Chin

Received: 21 November 2022;  Published: 08 February 2023;  doi: 10.21926/obm.icm.2301013

Lockdowns were a central strategy for managing the outbreak of COVID-19, and Melbourne, Australia had some of the most extensive restrictions globally during 2021. As a result, university students were faced with isolated living and challenging learning experiences. This pilot study occurred during 2021, close to both university assignment due dates and end of semester examinations and some of the longest lockdowns. Seventy-one participants responded to recruitment materials describing using music playlists to mana [...]

by Atena Samarehfekri  , Mohammad Ali Zakeri  , Hemn Kaka Mirza  , Adnan Rashid Aziz  and Mahlagha Dehghan

Received: 21 December 2022;  Published: 02 June 2023;  doi: 10.21926/obm.transplant.2302186

Foot reflexology has improved numerous physical and psychological symptoms in patients. The researchers in this study aimed to investigate the effect of foot reflexology on laboratory parameters, intake/output/weight and medication regimen after kidney transplant surgery. The research was a secondary analysis of a parallel randomized controlled trial. The research included patients who were admitted to the transplantation ward. The stratified randomization approach divided 53 eligible patients into two groups: foot [...]

by Louguangshu Huang  , Hui Liu  , Xiaoxia Xue  , Wuduo Zhao  and Tiesheng Li

Received: 13 December 2021;  Published: 03 February 2022;  doi: 10.21926/cr.2201003

In this article, an approach to generate self-assembly cyclopalladated polythiophene imine monolayers (denoted as ITO@Pd-CPTIMs) is described. The monolayers were fabricated by combining self-assembly (SA), hybrid doping (HD), and electrochemical polymerization (ECP) called SA-HD-ECP. The catalytic activity and stability of the polymerized monolayers in the Suzuki coupling reaction were improved by modulating the structure and morphology in hybrid doping using different thiophene derivatives, concentrations, and sc [...]

by Sharon Clevenger

Received: 02 April 2020;  Published: 18 May 2020;  doi: 10.21926/obm.icm.2002031

The novel coronavirus COVID-19 is a viral pathogen that first emerged in Wuhan, China in 2002 and has spread to 202 countries (as of March 28, 2020) [1]. Despite the fact that the 2005 SARS-CoV pandemic infected over 8,500 people, and caused over 800 deaths with billions of dollars in economic loss worldwide, as of 2015 there were still no clinically approved antiviral drugs, vaccines or monoclonal antibody therapies to treat SARS-CoV infections [2]. Antiviral medications that have been used to treat or control oth [...]

by Julia Baumann  , Eva Bönzli  , Franziska Wandrey  and Torsten Grothe

Received: 09 December 2024;  Published: 03 April 2025;  doi: 10.21926/obm.geriatr.2502305

The complex process of skin aging results in noticeable changes, including decreased collagen content, reduced elasticity, and decreased hydration. Interventions to preserve or restore collagen, a key structural protein, may help counteract these signs. The concept of "beauty from within” through nutritional supplements is of growing interest, particularly the use of plant-based alternatives to animal-derived or synthetic collagen. This study investigated the anti-aging potential of an extract from Moldavian dragon [...]

by José Antonio Latorre  , Cristóbal Abellán  , Alejandro López-Moro  , Nuria Giménez-Blasi  , Javier Conde-Pipo  and Miguel Mariscal-Arcas

Received: 07 November 2022;  Published: 27 February 2023;  doi: 10.21926/obm.geriatr.2301224

The leading causes of death in older adults involve nutritional risk factors, heart disease, cancer, stroke and diabetes. Prevalence of lifestyle diseases, older adults consider themselves in good, very good or excellent health. Older adults want to remain independent and not burden others; they believe proper nutrition and sufficient exercise will help them maintain their autonomy and independence. To describe the diet, nutrition and general health status of the older adult population in Spain and their adherence [...]

by Jazael Ballina  and Yun Ii Go

Received: 15 September 2024;  Published: 02 January 2025;  doi: 10.21926/jept.2501001

Performance degradation, including system deterioration, corrosion, and energy loss in solar PV systems, can be caused by environmental conditions such as high humidity, frequent rainfall, and temperature swings in tropical nations. Over the years, photovoltaic energy has been successfully developed to have low production costs and high efficiency. It has been the main reason that solar energy is one of the fastest-growing renewable energies in the world, with a generation of 821 TWh of electricity since 2021, repr [...]

by Jean Golding  , Rosie Clark  , Steven Gregory  , Genette Ellis  , Matthew Suderman  , Yasmin Iles-Caven  and Marcus E. Pembrey

Received: 17 May 2021;  Published: 29 October 2021;  doi: 10.21926/obm.genet.2104141

The FRAXE section of the FMR2 gene, located on the X chromosome, contains varying numbers of trinucleotide repeats; boys with over 200 repeats tend to have mild cognitive impairments, though this is rare. Little is known, however, concerning the phenotypes of individuals with smaller numbers of repeats. Here we answer the research question as to whether the health of ancestors of boys from whom the relevant X chromosome was inherited differed in any way according to the number of FRAXE repeats. Numbers of FRAXE rep [...]