by Allison Ast  , Margaret Meyer  , R. Elyse Heidelberg  , Jennifer M. Allen  , Amy Ly  and Holly Spraker-Perlman

Received: 02 December 2020;  Published: 08 February 2021;  doi: 10.21926/obm.icm.2101005

Children with cancer can experience intense suffering. Currently, despite our best efforts, symptoms associated with both cancer and its treatment result in physical, psychological, and emotional discomfort that can be difficult to manage with traditional Western medicine alone. Developing integrative services within a pediatric hematology-oncology program may help improve cancer-related symptoms by combining different modalities targeting overall health with traditional oncology care. This study details the initia [...]

by Minghan Bao  , Nagi Abdussamie  and Faisal AlThobiani

Received: 03 December 2022;  Published: 09 February 2023;  doi: 10.21926/jept.2301008

Analysing the structural response of offshore wind turbines (OWTs) requires a robust method to estimate environmental loadings associated with extreme weather conditions. This study aimed to accurately predict wind loadings on a non-rotating OWT using a Computational Fluid Dynamics (CFD) code, Ansys Fluent package. The inlet velocity boundary condition was defined as a uniform inlet wind speed and then as a Normal Wind Profile (NWP). Three large wind speeds of 25 m/s, 40 m/s and 50 m/s were tested with the aid of t [...]

by Otar Tsagareishvili  , Archil Mikeladze  , Roin Chedia  , Tamaz Batsikadze  and Levan Chkhartishvili

Received: 21 March 2024;  Published: 26 August 2024;  doi: 10.21926/rpm.2403021

Tungsten carbide WC-based materials characterized by high hardness and wear resistance have long been widely used in manufacturing cutting and mining tools. They are alloyed or modified with different ceramic phases to improve operational characteristics further. There are obtained the hard tungsten carbide–cobalt WC–Co and tungsten carbide–titanium carbide–cobalt WC–TiC–Co metal-ceramic alloys ultradispersed powders modified with quasieutectic ceramic alloy B4C–30wt.%TiB2 [...]

by Jai Jai Shiva Shankar  , Adil Bata  and Namita Sinha

Received: 07 August 2018;  Published: 25 October 2018;  doi: 10.21926/obm.neurobiol.1804013

(1) Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to investigate the frequency of isolated diffusion restriction that precede corresponding enhancement and to investigate the association between isolated diffusion restriction and survival in patients with GBM. (2) Metho [...]

by Shingo Nakamura  , Naoko Ando  , Masayuki Ishihara  and Masahiro Sato

Received: 09 August 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004119

The liver is a major organ with a wide range of functions, including detoxification, protein synthesis, and bile production. Liver dysfunction causes liver diseases such as hepatic cirrhosis and hepatitis. To explore the pathogenesis of these liver diseases, and the therapeutic agents against them, mice have been widely used as animal models. Genetic manipulation is easy in mice via the administration of nucleic acids (NAs) in the tail-vein. In particular, hydrodynamics-based gene delivery (HGD) is a method based o [...]

by Ameya Patil  , William E Sweeney  and Ellis D. Avner

Received: 07 August 2018;  Published: 23 December 2018;  doi: 10.21926/obm.genet.1804056

Renal cysts are present in a wide variety of hereditary renal diseases in children. The term polycystic kidney disease (PKD) refers to two specific hereditary diseases, distinguished by the usual age of onset and genetic cause: autosomal recessive polycystic kidney disease/congenital hepatic fibrosis (ARPKD/CHF, MIM *606702) and autosomal dominant polycystic disease (ADPKD-OMIM *601313 and OMIM *173910). ARPKD/CHF is characterized by cystic dilations of the renal collecting ducts and developmental defects of biliar [...]

by Yassamine Bentata

Received: 24 January 2024;  Published: 25 July 2024;  doi: 10.21926/obm.transplant.2403221

Completely unknown before the 90s and exceptional up to the 2000s, BK virus nephropathy (BKvN), usually known as polyomavirus-associated nephropathy, has emerged as a significant and severe viral complication in kidney transplantation (KT). More than twenty years after Gardner's discovery of BKv in 1971, Purighalla described, in 1995, the first case of BKvN. Four years later in 1999, Nickeleit et al. published a first series of five cases of BKvN and made very precious and pertinent contributions to understanding t [...]

by Jitu Mani Das  , Isha Behere  , Jnanendra Upadhyay  , Rajiv Borah  and Ganesh Ingavle

Received: 14 October 2022;  Published: 20 January 2025;  doi: 10.21926/obm.neurobiol.2501265

Regenerating injured nerves is difficult because they have little spontaneous regeneration potential. Advances in tissue engineering and regenerative medicine have emphasized the possibility of biomaterial-based methods for nerve healing. Natural protein-based biomaterials have benefits over synthetic ones, such as biocompatibility, non-immunogenicity, and biodegradability. Silk fibroin, generated from mulberry and non-mulberry silkworms, is especially promising because of its abundance, simplicity of processing in [...]

by Mieczysław Szyszkowicz

Received: 14 April 2021;  Published: 10 June 2021;  doi: 10.21926/aeer.2102014

Each country has its own characteristics of COVID-19 infection trajectory and epidemic waves. Differences in government-implemented restrictions and social regulations result in variability of the virus transmissions and spread dynamics. This in turn results in various shapes of the growth function used to represent and describe the propagation of infection. Statistical methods are applied to fit non-linear functions to represent daily time-series data of the cumulative numbers of COVID-19 cases. The aim of this wo [...]

by Yue Qiu  , Yinqian Kang  , Hao Liu  and Ibtesam Hilmi

Received: 12 May 2024;  Published: 30 August 2024;  doi: 10.21926/obm.transplant.2403224

Machine perfusion (MP) techniques, which simulate physiological conditions to allow for the assessment and preservation of organ viability, are currently applied in various solid organ transplantation fields. Owing to the growing demand for liver transplants and the scarcity of available donor livers, MP offers a practical solution for recovering high-risk grafts and increasing the number of potentially usable donor organs. Furthermore, testing and administering novel therapies to allografts may also become advanta [...]

by Igor Val Danilov

Received: 08 September 2024;  Published: 29 November 2024;  doi: 10.21926/obm.neurobiol.2404260

This narrative review of the literature on noninvasive brain stimulation techniques observes four neurostimulation domains: light therapy, photobiomodulation, a group of techniques within transcranial electric current and magnetic field stimulations, low-frequency sound stimulations, including vibroacoustic therapy, and rhythmic auditory stimulation. The review aims to determine whether or not different brain stimulation approaches rely upon a similar physicochemical sequence of actions. The study identifies releva [...]

by June An  and Young Nam Chun

Received: 30 October 2021;  Published: 01 December 2021;  doi: 10.21926/aeer.2104031

Renewable energies such as solar or wind energy are highly unreliable, owing to uncertain energy intensity and discontinuity. This shortcoming could be overcome by converting renewable energies to a form such as chemical fuel storage. In the present study, we created an energy conversion system that uses microwave heating and a carbon receptor to transform CO2, a greenhouse gas, into CO chemical fuel. The parametric investigation found that increasing the gasification temperature and feed gas temperature decreased [...]

by Stephanie Bryan  and Maryellen Hamilton

Received: 20 October 2023;  Published: 10 January 2024;  doi: 10.21926/obm.icm.2401008

This paper provides an overview of gratitude as a concept and as a mind-body-spirit practice, impacting health and human functioning throughout the lifespan, that can be integrated into daily life to great benefit at no cost. Current society is rife with increases in stress, anxiety, depression, lifestyle-related diseases, and social isolation. The practice of gratitude and its interrelated pro-social, health-enhancing, resilience-building effects suggest that promoting gratitude from childhood through adulthood ma [...]

by Chris R. Lavers  , Travis Mason  , Jonathan Mazower  and Sarah Grig

Received: 29 October 2020;  Published: 09 July 2021;  doi: 10.21926/aeer.2103018

High-resolution satellite imagery permits acquisition of critical data to observe climate-change and environmental impact on conflict-impacted indigenous communities with co-existing socio-economic factors, often within unstable regimes. Conflict may prevent direct access in remote regions to validate civilian conflict actor evidence. In such cases use of remote sensing tools, techniques, and data are extremely important. Software-based imagery assessment can quantify radiometrically calibrated or Normalized Differ [...]

by Subhomita Ghosh Roy

Received: 09 November 2022;  Published: 16 December 2022;  doi: 10.21926/aeer.2204052

With the increasing human population, the protection of water resources is becoming a critical issue. Wetlands are one of the most important water resources, helping assimilate pollutants. Hence, the ecosystem integrity of wetlands is important. Plant bioindicators with phytoremediation (physiologically removing pollutants from the ecosystem by plants) capacity can be very helpful in this regard. Based on the current literature, this study specifically aims to overview plant bioindicators with phytoremediation abil [...]

by Pal S. Mangat  , Shahriar Abubakri  , Konstantinos Grigoriadis  and Vincenzo Starinieri

Received: 24 June 2021;  Published: 09 October 2021;  doi: 10.21926/rpm.2104040

Microwave curing of repair patches provides an energy efficient technique for rapid concrete repair. It has serious economic potential due to time and energy saving especially for repairs in cold weather which can cause work stoppages. However, the high temperatures resulting from the combination of microwave exposure and accelerated hydration of cementitious repair materials need to be investigated to prevent potential durability problems in concrete patch repairs. This paper investigates the time and magnitude of [...]

by Myrto Poulou  and Maria Tzetis

Received: 31 July 2017;  Published: 01 November 2017;  doi: 10.21926/obm.genet.1704010

Cystic Fibrosis (CF) is one of the commonest autosomal recessive genetic diseases that show a high carrier frequency amongst Caucasian populations. Although there has been tremendous progress in the available therapies, compared to the past, the disease is still associated with significant morbidity and mortality. Because of the severe clinical manifestations and the shortened life expectancy of patients, population based carrier screening, to identify heterozygous carrier couples at risk of having affected childre [...]

by Elisabeth M. Sebesta  and Roger R. Dmochowski

Received: 17 May 2023;  Published: 05 October 2023;  doi: 10.21926/obm.geriatr.2304251

The evaluation and treatment of mixed urinary incontinence receives relatively little attention as compared to other forms of incontinence. Mixed incontinence, however, defined as the combination of stress and urgency incontinence, accounts for the largest proportion of incontinence, with an increased incidence in older women. The condition can be very challenging to manage due to the coexistence of multiple pathologies. Treating either component can worsen the other, which means careful discussion of the risks and [...]

by Dafné Silva  , Laís Nerys  , Carlos Silva  , Elizabeth Borba  , Tonny Leite  , Teresinha Silva  and Amanda Sena

Received: 27 May 2022;  Published: 25 August 2022;  doi: 10.21926/cr.2203024

Macambira plant (Bromelia laciniosa Mart. Ex Shult. & Schult. f.) is a species belonging to the family Bromeliaceae, which is distributed widely in the hinterlands of northeastern Brazil, from Bahia to Piauí states. The plants of this species contain an enzyme complex named bromelain, which has great potential for therapeutic applications. In the present study, bromelain derived from Bromelia laciniosa leaves was assessed for its thermodynamic properties and in vitro cytotoxic and healing activities. Bro [...]

by Ganisetti Vijay Kumar  , Min-Ze Lu  and Chang-Ming Liaw

Received: 19 December 2020;  Published: 31 May 2021;  doi: 10.21926/jept.2102023

This paper presents the development of a high-performance electric vehicle (EV) synchronous reluctance motor (SynRM) drive and its vehicle-to-grid (V2G) and vehicle-to-microgrid (V2M) bidirectional operations. The EV motor drive boostable DC-link voltage is established by a battery through a bilateral interface boost-buck DC-DC converter for good driving performance over a wide speed range. The motor efficiency is 92.3% near the rated load. In idle conditions, the embedded interface converter and inverter of the mo [...]

by Lucille Marchand  , Donna Lewin  and Leila Kozak

Received: 02 October 2020;  Published: 22 February 2021;  doi: 10.21926/obm.icm.2101007

Both palliative care (PC) and integrative medicine (IM) focus on the whole person to optimize wellbeing. Integrative palliative care combines the best of both approaches in relieving the distressing symptoms of serious illness and its treatment by combining evidence informed, pharmacological and nonpharmacological modalities that are aligned with the person’s goals, values and preferences. Healing is valued, as well as symptom relief, shared decisionmaking, person empowerment, compassionate care, and nurturing of h [...]

by Pawan Kumar Gautam  and Anoop Kumar Singh

Received: 11 July 2022;  Published: 30 January 2023;  doi: 10.21926/aeer.2301014

Tectonic geomorphology has been evidenced as an essential tool to define and measure recent tectonic deformation. The Nandakini River originates from Nanda Ghunti glacier at 6886 m in Lesser Himalaya. It covers about ~551 km2 basin area, with a fourth-order stream. It confluences with the Alaknanda River near Nand Prayag (at elevation 852 m), Chamoli district of Uttarakhand. The drainage pattern is predominantly dendritic in the study area. The morphotectonic indices are measured to know the tectonic activity of th [...]

by Elliot Nyagumbo  , Trust Nyirenda  , Cephas Mawere  , Alfred M. Mutaramutswa  , Godwins Ngorima  , Donald T. Kapanga  , Fabian Maunganidze  , Marvellous Matsheza  , William Pote  , Lucy Mabaya  and Michael Bhebhe

Received: 05 March 2025;  Published: 19 August 2025;  doi: 10.21926/obm.icm.2503036

Medicinal plants remain central to healthcare in Africa, where up to 80% of the population relies on traditional remedies to manage a range of health conditions, including skin ailments. In Zimbabwe, the country's rich biodiversity and favourable agroecological zones support a diverse range of ethnomedicinal plants. However, much of the knowledge surrounding these plants remains dispersed and scientifically under-evaluated. This review consolidates evidence from ethnobotanical surveys, peer-reviewed research, and g [...]

by Haruka Sawamura  , Kurumi Taniguchi  , Yuka Ikeda  , Ai Tsuji  , Yasuko Kitagishi  and Satoru Matsuda

Received: 16 November 2021;  Published: 08 March 2022;  doi: 10.21926/rpn.2201007

Immune checkpoints have been aggressively investigated for anti-cancer immunotherapy. The power of microbiota on the outcome of this immunotherapy has attracted much attention. For example, intestinal microorganisms play a key role in the effectiveness of programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. Additionally, short-chain fatty acids produced in the gut may modulate anti-CTLA4 and anti-PD1 stimulated immune responses and their anti-tumor efficacy. Enhancing the [...]

by Anilkumar Mettu  , Ninad Loke  , Vilas Patil  , Rahul Panday  and Sreenivasarao Gajula

Received: 10 January 2022;  Published: 19 July 2022;  doi: 10.21926/cr.2203021

In this study, we present selective hydrocracking of poly (di and tri) aromatic compounds to monoaromatics, such as benzene, toluene, and xylenes (BTX), over a mixture of Pt/Al2O3 and Y zeolites. The polyaromatic compounds feed is a combined simulated model feed, which is similar to light cycle oil (LCO) in composition. The feed is processed in a fixed bed reactor over a catalyst mixture: in the first step, selective hydrogenation of di and tri-aromatic compounds occurs in the presence of Pt/Al2O3 catalyst, followe [...]