Determining the Role of KRAS in Patients with Different Demographic Profiles Diagnosed with Diabetes Mellitus: A Case-Control Study
Abstract
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Determining the Role of KRAS in Patients with Different Demographic Profiles Diagnosed with Diabetes Mellitus: A Case-Control Studyby
Abstract
Diabetes mellitus (DM) is widely spread among populations. About 3 of 10 people show the symptoms of this disease. Many factors may cause this illness in both types (type 1 and type 2 DM), mainly attributed to insufficient insulin production in type 1 DM or developing insulin resistance in type 2 DM. Genes that control specific biochemical pathways involving glucose metabolism can interfere with the manifestation of this disease when they undergo genetic changes like KRAS. Investigating the role of KRAS in DM. Abou [...] 129 442 |
Development of Methods for Transplanting Human Islet within Macroencapsulation Device that Reverse Diabetes in Miceby
Abstract
Transplanting islets into the subcutaneous (SC) space rather than the portal vein is advantageous because this site is easier and safer to use. However, transplantation of islets directly or within planar devices has been unsuccessful in humans, mainly because of the low oxygen torr in the SC space. Since human islets are very different from mouse islets, the use of human islets in animal experiments to study SC islet transplantation may help to alleviate the roadblocks of this approach in humans. This is the first [...] 108 432 |
A New Model for the Shear of Atomic PlanesAbstract
The article presents a model that describes the shear of atomic planes in crystalline solids by accounting for their electronic structure. Previous studies have shown that an isotropic distribution of valence electrons leads to a spherically symmetric interatomic potential, which affects the stability of the crystal lattice against small shear deformations. Under these conditions, lattice stability is largely determined by the crystal's surface layer. As a consequence, the resistance to atomic-plane shear exhibits [...] 141 427 |
Assessment of Genetic Diversity and Polymorphism in Corylus avellana L. Pollen by Inter-Primer Binding Site Marker AnalysisAbstract
Genetically conditioned variation in pollen has been demonstrated to have a substantial influence on reproductive mechanisms and population dynamics. The present study evaluated the genetic variability of 28 pollen samples of Corylus avellana L. using iPBS (Inter Primer Binding Sites Polymorphism) markers 1882 and 2152. The collection of biological material was undertaken at various locations across five European countries, with the objective of capturing a broad spectrum of environmental conditions. The genetic re [...] 104 369 |
Central Post-Stroke Pain: Frequency, Clinical Characteristics, and Associated FactorsAbstract
Central post-stroke pain (CPSP) is a frequently underrecognized complication that contributes to long-term disability among stroke survivors. This study aimed to determine the frequency of CPSP and to describe its clinical characteristics and associated factors among stroke patients treated at Arifin Achmad General Hospital. A cross-sectional design was employed and included adult stroke patients with diagnoses confirmed by neuroimaging. CPSP was diagnosed based on the clinical criteria proposed by Klit et al., and [...] 72 334 |
Disability, Functional Limitations, and Family Violence among Older Adults in Brazil: A Cross-Sectional Study Using National Health Survey Data, Brazil 2019by
Abstract
Elder abuse is a global public health issue, with consequences on individual health, increased burden on healthcare systems, and high social costs. The study aimed to estimate the prevalence of family violence among older adults in Brazil and analyze its association with disability, comorbidities, functional limitation, and sociodemographic characteristics. Cross-sectional study using data from the 2019 National Health Survey (PNS 2019), including older adults aged 60 years or older. Bivariate and multiple logistic [...] 103 288 |
Beyond the Feed: Academic, Emotional, and Social Consequences of Social Media Use Among College StudentsAbstract
In 2025, college students are reportedly more anxious and strained than any previous generation of young people, while they are also the first to have grown up entirely immersed in social media. This research explores social media use patterns and their relationship with academic, emotional, health-related and social well-being among college students. A total of 111 college students from an East Coast university self-selected to complete a one-time assessment anonymously through Qualtrics. A mixed-methods, explorat [...] 56 272 |
Comprehensive Cytogenetic and ISSR Analysis in the Context of Conservation of the Local Breed of Brown Carpathian Cattle BreedAbstract
The article reveals the variability of the genome of cattle of the local small-numbered domestic Brown Carpathian breed using cytogenetic and molecular genetic polylocus markers, and justifies the need to integrate local breeds into the modern system of agricultural production in accordance with FAO requirements. The work aimed to study the genetic uniqueness of cows of the brown Carpathian breed using cytogenetic and molecular genetic markers. The karyotype of the animals corresponded to the species norm and was 2 [...] 31 129 |
Photovoltaic Power Forecasting Without Local Data: A Spatially-Aware Approach Using Neighboring Plantsby
Abstract
The increasing demand for renewable energy sources has intensified the adoption of photovoltaic systems. This study proposes predictive models for solar power generation that operate without dependence on on-site meteorological stations. The proposed approach integrates generation data from geographically distributed plants and accounts for the distance to meteorological stations when constructing climatic variables. Two machine learning techniques, Random Forest (RF) and Long Short-Term Memory (LSTM) networks, wer [...] 28 100 |
Phytochemically Rich Food-System By-Products in Ruminant Diets: Nutritional and Health Benefits from Animals to Humans within a Circular BioeconomyAbstract
Food-system by-products (FSBP), including agricultural by-products, agro-industrial co-products, and food-processing residues, represent an underused source of nutrients and plant secondary compounds with significant potential in ruminant feeding systems. This review synthesized 96 peer-reviewed studies published between 2000 and 2025 on phytochemically rich FSBP in ruminant diets, focusing on composition, rumen fermentation, animal health and performance, product quality, and environmental outcomes. Across the stu [...] 22 81 |
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