by Sana Parveen  , Suroor Fatima Rizvi  , Adria Hasan  , Uzma Afaq  and Snober S. Mir

Received: 28 June 2022;  Published: 08 November 2022;  doi: 10.21926/obm.genet.2204170

The autophagy mechanism recycles the damaged and long-standing macromolecular substrates and thus maintains cellular homeostatic and proteostatic conditions. Autophagy can be an unavoidable target in cancer therapy because its deregulation leads to cancer formation and progression. Cancer can be controlled by regulating autophagy at different genetic, epigenetic, and post-translational levels. Epigenetics refers to the heritable phenotypic changes that affect gene activity without changing the sequence. Modern biol [...]

by Taofiq O. Mohammed  , Mohammad Zunaied Bin Harun  , Jian Liu  and Ebenezer O. Fanijo

Received: 04 June 2025;  Published: 04 September 2025;  doi: 10.21926/rpm.2503013

The high carbon footprint of cement production and the cost and environmental impact of steel reinforcement make conventional concrete unsustainable for long-term use. Reducing cement consumption and identifying sustainable, cost-effective alternatives to steel are critical for lowering construction’s ecological and economic burden. Bio-based supplementary cementitious materials (SCMs), such as rice husk ash (RHA), and natural plant fibers show promise, but prior studies have mostly tested them separately or with v [...]

by Hassan-Ali Hakemi

Received: 11 October 2020;  Published: 08 December 2020;  doi: 10.21926/rpm.2004023

In this work, the experimental data on flexible PDLC films at the industrial scale and the effect of cure temperature (Tc) on the morphology and electro-optical properties of a UV-cured PDLC system via polymer-induced phase separation (PIPS) method were studied. Under constant UV radiation intebsity and thickness, the morphological parameters such as dimension, number density, and volume fraction of the phase-separated liquid crystal droplets as well as the optical transmissions and switching voltages as a function [...]

by Kohl Jacobson  , Sam Strassler  , Courtney Spalt  , Sara Henry  , Arthur Powers  and Donald W. Radford

Received: 22 December 2020;  Published: 29 March 2021;  doi: 10.21926/rpm.2101008

Continuous fiber reinforced geopolymer matrix composites offer the potential for use in structural applications at temperatures up to 700°C, while enabling the manufacture at temperatures below 100°C. Studies have investigated a variety of high temperature structural fiber reinforcements, including carbon, SiC and Al2O3. While there has been active research into various grades of Al2O3 fibers, SiC is most commonly used for high temperature reinforcement of geopolymers in oxidizing environments. Both familie [...]

by Lyndsie Koon  , Robert Brustad  and Megan Babkes Stellino

Received: 15 May 2019;  Published: 27 November 2019;  doi: 10.21926/obm.icm.1904064

Physical activity participation has been found to favorably influence cognitive function across the lifespan. Specific characteristics, or qualities, of physical activity involvement (e.g., type, intensity, level of cognitive demand) may yield particular benefits. The purpose of this study was two-fold. The first objective was to develop taxonomies for two physical activity characteristics of interest: the level of task complexity (motoric and cognitive) and the level of social engagement. The second objective was [...]

by C. Shah Kabir

Received: 28 March 2023;  Published: 12 June 2023;  doi: 10.21926/jept.2302019

Investigations on two-phase gas/liquid flow in pipes have been under study for nearly six decades. These studies have significantly assisted in managing fluid flow in the wellbore and surface networks, leading to the separation of phases and transmission of oil and gas into the market. This study summarizes some of the main lessons learned in flow through wellbores. Besides understanding some of the fundamental principles, we focused on the practical items of interest: Conventional production scenarios for oil and [...]

by Masayuki Nigo  , Rodrigo Hasbun  and Karen J Vigil

Received: 29 March 2018;  Published: 02 November 2018;  doi: 10.21926/obm.transplant.1804023

Liver transplantation is a life-saving procedure available worldwide. Despite advances in its surgical and immunosuppressive strategies, infectious complications carry significant morbidity and mortality. Bacterial infections are the most common infective etiologies, and the majority are seen during the first four weeks post liver transplantation. Infectious complications are often intra-abdominal in origin, such as biliary complications and abdominal abscesses. Infections due to multi-drug resistant organisms are [...]

by Ron Hochstenbach  , Martin Poot  and Thomas Liehr

Received: 15 November 2016;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701002

Small supernumerary marker chromosomes (sSMCs) are centric chromosome fragments additionally present in an otherwise normal human chromosome set that cannot be characterized by classical cytogenetic techniques alone. The majority of sSMCs are not yet related to a defined clinical phenotype. We compiled from the literature all 78 cases with multiple sSMCs per cell in which the chromosomal origin of the sSMCs has been identified. The number of sSMCs varies from 2 to 7; 64% have 2 sSMCs, 14% have 3 sSMCs, and the freq [...]

by Evelyne El Masri  and Tat-Hean Gan

Received: 28 May 2020;  Published: 27 August 2020;  doi: 10.21926/rpm.2003020

Carbon fibre reinforced polymer (CFRP) systems as sheets or plates are commonly used to strengthen and retrofit damaged reinforced concrete beams. In general, the bond between the FRP element and concrete defines the effectiveness of the externally bonded FRP materials. In most cases, the interface bonding behaviour is usually tested via static loading conditions. In this paper, the bonding is verified under dynamic conditions. Wave propagation is modelled in delaminated CFRP strengthened reinforced concrete beam. [...]

by Abolfath Askarian Khoob  , Mohammad Javad Ramezani  and Seyed Sina Mousavi

Received: 16 June 2022;  Published: 12 May 2023;  doi: 10.21926/rpm.2302021

This study intends to determine the behavior of glass laminate aluminum-reinforced epoxy (GLARE) and glass fiber-reinforced polymer (GFRP) composites under a low-velocity impact test. Experimental tests and numerical simulations are considered for this investigation. All samples are made by the hand lay-up method. Moreover, specimens are produced with a 7075-T6 aluminium sheet with a 0.5 mm thickness, resin 3001, and E-glass fiber. The drop weight test performs the low-velocity impact at 6.7 J and 10 J impact energ [...]