by Diane B. Paul  and Ilana Löwy

Received: 16 April 2018;  Published: 12 June 2018;  doi: 10.21926/obm.genet.1802022

We address an ongoing controversy over what health-care providers tell prospective parents about Down Syndrome (DS). Many parent, disability-rights, and anti-abortion activists believe that the messages that health-care professionals transmit to pregnant women and their partners are distorted. In their view, OB-GYNs, primary-care providers, clinical geneticists, midwives and other medical professionals generally assume that the quality of life for individuals with DS and their families is poor, whereas in fact, tho [...]

by Edwin Meresh  , Clinton Korneffel  , Bavani Rajah  and Ryan Bergren

Received: 23 December 2020;  Published: 23 March 2021;  doi: 10.21926/obm.neurobiol.2101089

Catatonia can occur in patients diagnosed with schizophrenia and bipolar disorder and malignant catatonia is life threatening. Anti-psychotic medications should be discontinued during acute phase of catatonia. Anti-psychotic discontinuation in catatonia is a challenge in patients maintained on long-acting injectable antipsychotics because of the extended release. Case report: We present a case of malignant catatonia developed in a patient with history of schizophrenia and developmental delay. Symptoms lasted severa [...]

by Andrew Sluyter

Received: 07 March 2021;  Published: 24 August 2021;  doi: 10.21926/aeer.2103020

This project demonstrates how to use existing syntheses of many decades of historical social science research to produce empirically derived land-use maps in a GIS for large regions for a specific target year at a resolution appropriate to the calibration of existing anthropogenic land-cover change (ALCC) models. Disagreement among the outputs of various ALCC models results from differing estimates of population and assumptions about how much food a given population requires and the productivity per unit area of va [...]

by Gerald Schlaf  , Jakob Kehlen  , Anja Wahle  , Diana Mauer  and Wolfgang Altermann

Received: 26 January 2021;  Published: 02 June 2021;  doi: 10.21926/obm.transplant.2102142

The specification of anti-human leukocyte antigen (HLA) antibodies is an important task for patients awaiting kidney allografts. Especially the patients immunized in previous transplantations, transfusions, or pregnancies must be carefully observed, since grafting patients with HLA antigens/phenotypes recognized by their pre-formed antibodies are the main cause of harmful hyperacute and acute rejection. The complement-dependent lymphocytotoxicity-based de facto (physical) crossmatching (CDC-CM) has thus been implem [...]

by Mohammad Shanawar Khan  and Shohel Amin

Received: 15 May 2022;  Published: 04 August 2022;  doi: 10.21926/rpm.2203013

This study examines the chemical compositions of eggshell powder (ESP) and lime as the soil stabilisers and compared with the compositions of cement and fly-ash to understand the optimal distribution of chemical stabilisers maximising the bearing capacity and structural integrity of subgrade soil. The different proportions of eggshell powder (ESP) (2%, 4%, 6% and 8% of total soil mass) were mixed with a fixed proportion of lime (6% of total soil mass) to analyse the optimum proportion of eggshell maximising the soi [...]

by Hanane Merhmi  , Maria Zerkaoui  , Abdelhafid Natiq  , Aziza Sbiti  , Thonas Liehr  and Abdelaziz Sefiani

Received: 25 July 2018;  Published: 22 July 2019;  doi: 10.21926/obm.genet.1903085

Background: A report of two new Moroccan cases with polymalformative syndrome, in which we identified similar but not identical sSMCs derived from chromosome 14. Methods: Conventional karyotype and MULTI-FISH. Results: +del(14)(q21.1) in the first case and +del(14)(q21.2) in the second. Conclusions: Constitutional partial trisomy 14 has an expanded clinical spectrum as one case from the literature was associated with gonadal tumor development. Similar cases, including the ones reported here, need to be carefully fo [...]

by Mahyar Vefaghi  , Hediyeh Rezaei Sedehi  and Omid Ashkani

Received: 09 April 2025;  Published: 03 August 2025;  doi: 10.21926/rpm.2503012

Nowadays, the development of advanced processors plays a key role in the progress of humanity and the discovery of new sciences, and quantum computers play an essential role in this regard. In this regard, the development of new generation processors is necessary for the development of quantum computers. Quantum diamonds, with their astonishing properties, especially the presence of nitrogen-vacancy (NV) centers in their crystalline structure, are among the most advanced emerging technologies in the field of quantu [...]

by Makeda L. Robinson  , Kyle Enriquez  and Dora Y. Ho

Received: 02 November 2018;  Published: 08 January 2019;  doi: 10.21926/obm.transplant.1901038

Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West Nile virus (WNV) which has become endemic in the US since its arrival in 1999 and Zika virus (ZIKV) which recently spread across the Americas. These events demonstrate the speed with which a vector-borne pathogen can disseminate when introduced into a susceptible population with [...]

by Myunik Panthi

Received: 25 May 2023;  Published: 01 December 2023;  doi: 10.21926/obm.geriatr.2304259

This article explores the adaptation process of older adults in residential care facilities in New Zealand. Through a phenomenological approach, this study provides clarity on how older adults adjust in residential care despite losses and challenges. Qualitative data on 24 older adults, 6 residential care facilities, and 10 staff were collected. Utilising qualitative software the following were identified: loss, support, acceptance and meaningful support. Initially, the unfamiliar environment and faces, structured [...]

by Divya B. Mella  , Josie Sewell  and Edward Pan

Received: 12 October 2018;  Published: 01 November 2018;  doi: 10.21926/obm.neurobiol.1804014

Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent used in gliomas, which has been given to patients with prolactinomas refractory to conventional treatments. Methods: Retrospective chart review was conducted for refractory prolactinoma patients treated between 2008 and 20 [...]