by Jai Jai Shiva Shankar  , Adil Bata  and Namita Sinha

Received: 07 August 2018;  Published: 25 October 2018;  doi: 10.21926/obm.neurobiol.1804013

(1) Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to investigate the frequency of isolated diffusion restriction that precede corresponding enhancement and to investigate the association between isolated diffusion restriction and survival in patients with GBM. (2) Metho [...]

by Julian Gross  , Karin Matko  , Jill Vennemann  and Holger Carl Bringmann

Received: 31 July 2021;  Published: 14 December 2021;  doi: 10.21926/obm.icm.2104054

Meditation-Based Lifestyle Modification (MBLM) is a complex eight-week mind-body intervention based on the traditional eight-fold path of classical yoga. MBLM was developed for mental health care, and it combines ethical living, physical yoga, and meditation. In this qualitative study, the subjectively perceived efficacy of MBLM was compared to the perceived efficacy of an individually tailored, multi-professional psychiatric treatment (MPT) in a psychiatric outpatient clinic. Twelve patients were interviewed for t [...]

by Chenggong Han  , Hancong Tang  , Shuyuan Lou  , Yuan Gao  , Min Ho Cho  and Shili Lin

Received: 23 May 2018;  Published: 14 October 2018;  doi: 10.21926/obm.genet.1804041

Whole genome profiling of differential DNA methylation between diseased and normal samples has significant implications in research to understand the role of epigenetic regulations of cells. In recent years, the development of bisulfite sequencing (BS-seq)-based molecular technology has enabled the measurement of DNA methylation at a nucleotide resolution throughout the genome. Given the availability of this new type of DNA methylation data, certain features challenge traditional analytical methods such as the Fish [...]

by June An  and Young Nam Chun

Received: 30 October 2021;  Published: 01 December 2021;  doi: 10.21926/aeer.2104031

Renewable energies such as solar or wind energy are highly unreliable, owing to uncertain energy intensity and discontinuity. This shortcoming could be overcome by converting renewable energies to a form such as chemical fuel storage. In the present study, we created an energy conversion system that uses microwave heating and a carbon receptor to transform CO2, a greenhouse gas, into CO chemical fuel. The parametric investigation found that increasing the gasification temperature and feed gas temperature decreased [...]

by Moira A. Law  , Pamela Pastirik  and Isdore Chola Shamputa

Received: 31 August 2022;  Published: 28 January 2023;  doi: 10.21926/obm.icm.2301009

The experience of loss due to death, illness, and social mitigation was inevitable during the COVID-19 pandemic. Mental health services are chronically difficult to access in Canada, and this barrier is further exacerbated when trying to access certified art therapists to deliver expressive arts therapy. This pilot project attempted to provide an alternative to this service through an interprofessional alliance with a professional artist and certified counselors. A small group (n = 6) of vulnerable youth who had su [...]

by Nagarajan Paramasivam  , Martin Granzow  , Christina Evers  , Katrin Hinderhofer  , Stefan Wiemann  , Claus R. Bartram  , Roland Eils  and Matthias Schlesner

Received: 24 October 2017;  Published: 16 April 2018;  doi: 10.21926/obm.genet.1802017

Background: With genome sequencing entering clinics as a diagnostic tool to detect genetic disorders, there is an increasing need for bioinformatics-based solutions that enable precise causal variant identification in a timely manner. Workflows for the identification of candidate disease-causing variants usually perform the following tasks: i) identification of variants; ii) filtering of variants to remove polymorphisms and technical artifacts; and iii) prioritization of remaining variants to provide a small set of [...]

by Pal S. Mangat  , Shahriar Abubakri  , Konstantinos Grigoriadis  and Vincenzo Starinieri

Received: 24 June 2021;  Published: 09 October 2021;  doi: 10.21926/rpm.2104040

Microwave curing of repair patches provides an energy efficient technique for rapid concrete repair. It has serious economic potential due to time and energy saving especially for repairs in cold weather which can cause work stoppages. However, the high temperatures resulting from the combination of microwave exposure and accelerated hydration of cementitious repair materials need to be investigated to prevent potential durability problems in concrete patch repairs. This paper investigates the time and magnitude of [...]

by Minghan Bao  , Nagi Abdussamie  and Faisal AlThobiani

Received: 03 December 2022;  Published: 09 February 2023;  doi: 10.21926/jept.2301008

Analysing the structural response of offshore wind turbines (OWTs) requires a robust method to estimate environmental loadings associated with extreme weather conditions. This study aimed to accurately predict wind loadings on a non-rotating OWT using a Computational Fluid Dynamics (CFD) code, Ansys Fluent package. The inlet velocity boundary condition was defined as a uniform inlet wind speed and then as a Normal Wind Profile (NWP). Three large wind speeds of 25 m/s, 40 m/s and 50 m/s were tested with the aid of t [...]

by Allison Ramsey  , Christine Natori  , Kristen Cisneros  , David J. Ross  and Abbas Ardehali

Received: 27 March 2020;  Published: 06 May 2020;  doi: 10.21926/obm.transplant.2002107

Biomarker surveillance after solid organ transplant is an advancing field with promise for further elucidation through high-throughput analyses and “omics” technologies. To date, Gene Expression Profiling (GEP; AlloMapâ) is the only FDA-cleared genomic assay as surveillance for moderate-severe TCMR versus allograft quiescence after heart transplantation. Clinical validity and utility, however, have been recently established after kidney and heart transplantation, for analysis of donor-derived cell-free DNA in the a [...]

by Myrto Poulou  and Maria Tzetis

Received: 31 July 2017;  Published: 01 November 2017;  doi: 10.21926/obm.genet.1704010

Cystic Fibrosis (CF) is one of the commonest autosomal recessive genetic diseases that show a high carrier frequency amongst Caucasian populations. Although there has been tremendous progress in the available therapies, compared to the past, the disease is still associated with significant morbidity and mortality. Because of the severe clinical manifestations and the shortened life expectancy of patients, population based carrier screening, to identify heterozygous carrier couples at risk of having affected childre [...]