by Caymen M. Novak  , Eric N. Horst  , Shreya Raghavan  and Geeta Mehta

Received: 17 June 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903092

Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, and metastasis, and has been linked to the mechanotransduction of breast cancers. However, it is not currently known if shear stress mediated mechanotransduction is affected by COX-2. Therefore, in this report, we hypothesized that COX-2 m [...]

by Erina White  , Farzane Mohseni  and Meisam Amani

Received: 28 August 2021;  Published: 04 November 2021;  doi: 10.21926/aeer.2104028

The vitality of the Great Barrier Reef (GBR) is threatened by many human-made impacts. Monitoring this ecosystem makes it possible to study the general condition and the health of the GBR. However, due to the large extent of the GBR and limited accessibility in the ocean environment, mapping and monitoring this ecosystem has been always challenging task and connived. In this regard, Remote Sensing (RS) is an effective technique that provides valuable information for mapping and monitoring this ecosystem. In an atte [...]

by Kazuki Mochizuki  , Chihiro Imai  , Noriko Sato  and Takeo Kubota

Received: 20 June 2017;  Published: 19 October 2017;  doi: 10.21926/obm.genet.1704008

A number of epidemiological studies have suggested that environmental stresses, such as malnutrition during the fetal period, can induce development of metabolic disorders, such as obesity, type 2 diabetes, and hypertension, and and even psychiatric disorders in later life. This theory model is known as the Developmental Origins of Health and Disease (DOHaD) theory, in which postulates that “epigenetic memories”, involving DNA methylation, histone modifications and microRNA expression, are induced by environmental [...]

by Naireeta Deb  and Rajendra Singh

Received: 15 November 2022;  Published: 08 February 2023;  doi: 10.21926/jept.2301007

Widespread adoption of electric vehicles has presented the challenges of short range and prolonged charging time. Going forward, extremely fast charging is the only solution to these problems. However, the typical Silicon power electronics supported 400 V electric vehicle powertrain cannot live up to this challenge. Limitations include the huge cable size, heating of equipment due to high current and user safety, to name a few. In this paper, we have analyzed an 800 V EV powertrain using power electronics based on [...]

by Divya Taneja  , Madhumita Sadhukhan  , Padmalaya Rath  , Manas R Sarangi  , Renu Mittal  , Akshaya Kumar Prusty  , Deepthi Gilla  , Ashish Shivadikar  , Birendra Rawat  , Ravi Kumar Sadarla  , Gurudev Choubey  , Nidhi Mahajan  , Renu Bala  , Neha Kalra  , Anupam Mukherjee  , Anil Khurana  and Raj K. Manchanda

Received: 12 August 2022;  Published: 21 September 2022;  doi: 10.21926/obm.icm.2203044

Patients with psoriasis commonly opt for homeopathic treatment. However, no study has assessed the response to homeopathic treatment by using standardized disease-specific scales, and the findings are based on clinical assessments only. The objective of this study was to evaluate the response to the individualized homeopathic treatment of psoriasis with respect to changes in disease severity and quality of life based on Psoriasis Area and Severity Index (PASI) and Psoriasis Disability Index (PDI) scales, respective [...]

by Seong Soo Choi  , Byung Seong Bae  , Kyoung Jin Kim  , Myoung JIn Park  , Yong Min Lee  , Hyun Tae Kim  and Soo Bong Choi

Received: 22 December 2020;  Published: 05 February 2021;  doi: 10.21926/rpm.2101004

We fabricated various nanoaperture plasmonic platforms for single-molecule detection. We fabricated nanoapertures like nanopores on a pyramid and nanoslits on an Au flat membrane using a Ga ion focused ion beam drilling technique, followed by irradiating with a high energy electron beam, dependent on the electron beam current density to obtain nanoapertures with a few nanometer sizes (circular nanopore, nanoslit pores). We examined their optical characteristics with varying aperture sizes and sample thicknesses. We [...]

by Stephen Ames

Received: 08 April 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903068

Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the standing or status bestowed on one human being by others in the context of relationships and social being and held that respect for the absolute value of each person is a key theme in Western ethical discourse. He was clear thi [...]

by Obumneme Emmanuel Ezeani  , Christopher Igwe Idumah  , Ifeanyi Emmanuel Okoye  and Chioma Joan Ikebudu

Received: 13 January 2025;  Published: 27 May 2025;  doi: 10.21926/rpm.2502009

Nanotechnology has revolutionized the textile industry by introducing innovative finishing techniques that enhance the durability and performance of textile materials and the application of nanoscale/nanoparticles/nanomaterials and processes to improve the properties and performance of textiles. The synergism of textile technology and nanotechnological advancements has propelled a paradigm shift, changed the narrative, and formed novel platforms for textile surface engineering at both atomically affiliated and mole [...]

by Joep P.M. Geraedts

Received: 15 December 2020;  Published: 28 January 2021;  doi: 10.21926/obm.neurobiol.2101085

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic te [...]

by Ryan L Dimmock  , Xuyiling Wang  , Yibin Fu  , Alicia J El Haj  and Ying Yang

Received: 09 December 2019;  Published: 28 February 2020;  doi: 10.21926/rpm.2001005

Advancements in surface engineering and material fabrication techniques have enabled the creation and replication of naturally occurring surface topographies or the extrapolation of natural patterns to become achievable targets. Polymers are used extensively in the field of biomedical sciences for containment, handling, and as cell culture substrates. It is well established that several polymers exhibit good biocompatibility for cell culture, with properties that include exhibiting minimal to no cytotoxicity and be [...]