by Seong Soo Choi  , Byung Seong Bae  , Kyoung Jin Kim  , Myoung JIn Park  , Yong Min Lee  , Hyun Tae Kim  and Soo Bong Choi

Received: 22 December 2020;  Published: 05 February 2021;  doi: 10.21926/rpm.2101004

We fabricated various nanoaperture plasmonic platforms for single-molecule detection. We fabricated nanoapertures like nanopores on a pyramid and nanoslits on an Au flat membrane using a Ga ion focused ion beam drilling technique, followed by irradiating with a high energy electron beam, dependent on the electron beam current density to obtain nanoapertures with a few nanometer sizes (circular nanopore, nanoslit pores). We examined their optical characteristics with varying aperture sizes and sample thicknesses. We [...]

by Sana Sandhu  , Anindita Arpa  , Xi Chen  , Rahul Kumar  and Justyn Jaworski

Received: 15 September 2019;  Published: 25 November 2019;  doi: 10.21926/rpm.1904006

Increasing interest in bacterial cellulose due to the huge potential which exists for the development of this new biomaterial for medical applications has been met with recent growth in research in engineering this unique microbial manufactured material. The mechanical properties, porosity, and biocompatibility of bacterial cellulose derived biomaterials are particularly attractive for use in wound healing, tissue engineering, and drug delivery applications. Advances in synthetic biology and soft materials engineer [...]

by Fengxia Liang  and Gerhard Litscher

Received: 25 February 2020;  Published: 26 February 2020;  doi: 10.21926/obm.icm.2001009

Traditional Chinese Medicine (TCM) has been used to prevent and alleviate epidemic diseases for hundreds of years. The combination of TCM and Western medicine can effectively reduce fever; alleviate cough, fatigue, diarrhoea and other symptoms of patients with mild COVID-19 (Coronavirus disease-19). For the treatment of moderate and severe syndromes, the integrative approach can reduce lung exudation and inhibit the further development of the disease. However the risk of infection is a limit for example in needle a [...]

by Xinying Hong  and Miao He

Received: 04 May 2022;  Published: 02 August 2022;  doi: 10.21926/obm.genet.2203161

Galactosemia is a group of hereditary disorders of galactose metabolism. Newborn screening for galactosemia type I is mandatory in all states in the US since timely intervention can prevent life-threatening sequela. The biochemical basis, clinical presentation, and potential treatment options for different types of galactosemia are described. This review has a focus on the screening methodologies, including the principle of the assay, the transition from the initial bacteria inhibition test to the modern fluorometr [...]

by Helena M. Minyé

Received: 06 February 2020;  Published: 18 May 2020;  doi: 10.21926/obm.neurobiol.2002057

Temporomandibular disorders (TMD) are a group of musculoskeletal and neuromuscular conditions that involve the temporomandibular joint (TMJ), the masticatory muscles, and branches of the trigeminal nerve. TMD is the most common chronic oral facial pain disorder. Pain associated with TMD can be clinically expressed as myogenous or arthrogenous in etiology. The myogenous variant of TMD is characterized by pain in the muscles of mastication. The arthrogenous form of TMD is caused by pain in the joint leading to synovi [...]

by Clarissa E.H. Fang  , Li Guo  , Daniel Hill  , Timothy E. Yap  and M. Francesca Cordeiro

Received: 16 April 2020;  Published: 15 June 2020;  doi: 10.21926/obm.neurobiol.2002062

Neuroprotection in glaucoma is any medical treatment by which decline in visual function can be slowed or prevented by supporting the health and survival of neural cells, independent of lowering of intraocular pressure (IOP). This is achieved by targeting mechanisms to inhibit or delay retinal ganglion cell death and promote cell survival pathways. Despite demonstrating promising results in preclinical trials, many neuroprotective strategies have failed to show success in subsequent clinical trials. Of the clinical [...]

by Karen E. Burke  , Xueyan Zhou  , Yongyin Wang  and Huachen Wei

Received: 29 July 2021;  Published: 13 December 2021;  doi: 10.21926/obm.geriatr.2104184

The supplement telomerase activator TA-65 (purified from Astragalus membranaceus) has been shown to retard cellular senescence, boost the aging immune system, and retard age-related symptoms. Lengthened telomeres retard aging, but because cancers often maintain longevity by lengthening telomeres, dietary telomerase activator might possibly increase tumorigenesis. This study investigated whether oral TA-65 effects the timing of onset and/or the incidence of skin cancers induced by UVB-irradiation and whether that po [...]

by Ben Milborne  , Abul Arafat  , Rob Layfield  , Alexander Thompson  and Ifty Ahmed

Received: 18 March 2020;  Published: 12 May 2020;  doi: 10.21926/rpm.2002012

Radiotherapy has become one of the most prominent and effective modalities for cancer treatment and care. Ionising radiation, delivered either from external or internal sources, can be targeted to cancerous cells causing damage to DNA that can induce apoptosis. External beam radiotherapy delivers either photon radiation (x-rays or gamma rays) or particle radiation (neutrons or protons) in a targeted manner to specific tumour locations. Internal radiotherapy involves placing radioactive sources within the body to de [...]

by Scarlett Puebla-Barragan  , Britney Lamb  , Serenah Jafelice  and Gregor Reid

Received: 16 June 2021;  Published: 01 November 2021;  doi: 10.21926/obm.icm.2104040

Vaginal care products are widely used by women to relieve discomfort such as pain, itching and malodour, all of which are commonly caused by conditions resulting from microbiota dysbiosis. Previous studies showed that probiotic strains Lacticaseibacillus (formerly Lactobacillus) rhamnosus GR-1 (LGR-1) and Limosilactobacillus (formerly Lactobacillus) reuteri RC-14 (LRC-14), can aid in restoring homeostasis in the vaginal microbiome when taken orally. A topical product containing these strains could be of value for r [...]

by Elissavet Feloni  and Evgenia Karandinaki

Received: 08 May 2021;  Published: 17 August 2021;  doi: 10.21926/jept.2103039

The objective of this study is the development and implementation of a geographic information system (GIS)-based methodology to determine suitable sites for wind farms by using multicriteria decision making (MCDM) techniques. Many eligibility criteria are considered in this approach, such as GIS analysis is performed in combination with MCDM techniques, both for the criteria weighting process (using the analytical hierarchical process) and for the standardization/classification of the criteria values into a common [...]