by Monika Pliszka  and Leszek Szablewski

Received: 06 March 2020;  Published: 07 August 2020;  doi: 10.21926/obm.hg.2003050

The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Similarly, human health depends on the composition of gut microbiome, with gut bacteria playing a crucial role in human physiology. For instance, gut microbiota synthesizes vitamins and amino acids, and affects the biotransfor [...]

by Oliver Reed  , Patrick B Allen  , Grant Caddy  , John Eccles  and Tony CK Tham

Received: 28 January 2019;  Published: 26 March 2019;  doi: 10.21926/obm.hg.1901015

Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract which can result in luminal stenosis and up to 90% of patients requiring surgery during their lifetime. Medical management aims to reduce the inflammatory burden to prevent the development of inflammatory strictures, progression to fibro-stenosis and subsequent obstructive symptoms. Endoscopic balloon dilatation (EBD) is a well-established, safe technique in the management of short strictures to prevent patients having multiple surgic [...]

by Negar Noorbakhsh  , Mina Zamani  , Alireza Sedaghat  , Jawaher Zeighami  , Farangis Foroughi Behbahani  , Sahere Parvas  , Alihossein Saberi  , Mohammad Hamid  , Roya Ghanavati  , Gholamreza Shariati  and Hamid Galehdari

Received: 11 October 2022;  Published: 12 May 2023;  doi: 10.21926/obm.genet.2302181

Familial Mediterranean Fever (FMF) is classified as an autoinflammatory genetic disease inherited by mutations in MEFV. These mutations can affect the dysregulation of inflammatory processes in the human body and lead to fever and pain in the chest and abdomen. Many known missense mutations in MEFV are linked to FMF disease. Mutations in MEFV in most cases are located on the short arm of chromosome 16 and can impair the function of the pyrin protein. In this research, we aimed to examine the entire exons of MEFV fo [...]

by Rhythm Joshi  , Zehva Khan  , Aakriti Garg  , Nidhi  , Ubada Aqeel  , Dinesh Bhurani  and Mohd.Ashif Khan

Received: 30 September 2022;  Published: 25 April 2023;  doi: 10.21926/obm.transplant.2302183

Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. However, the cure can only be achieved at the price of morbidity and long-term complications such as bone diseases leading to fractures and osteopenia. Several studies have reported the impact of organ transplants on bone metabolism, electrolytes and blood profile. This prospective observational clinical study aims at elucidating the [...]

by Rositsa Hristova  , Dimka Georgieva  , Albena Staynova  and Valeria Hadjidekova

Received: 14 August 2018;  Published: 25 November 2018;  doi: 10.21926/obm.genet.1804051

Background: A radiation accident occurred on 14 June 2011 in an industrial facility in Bulgaria with a cobalt source (137 TBq) that was used to sterilize equipment. Five people received doses exceeding 1Gy, which led to the development of acute radiation syndrome. Biological dosimetry based on dicentric analysis was performed and the average acute whole-body doses estimated for the five patients ranged from 1.2 to 5.6 Gy. The purpose of this study was to evaluate induced chromosome aberrations in vivo four months af [...]

by Noa Sylvetsky  , Chen Futeran Shahar  , Meir Frankel  and Gabriel Munter

Received: 01 April 2020;  Published: 02 July 2020;  doi: 10.21926/obm.geriatr.2003126

Hospitalists are at risk for vitamin D deficiency during their active years due to indoor working conditions and insufficient sunlight exposure. The impairment of bone mineral density (BMD) in this group has not been studied. A total of 50 male hospitalists aged ≥ 65 years were enrolled. Their BMD was measured at the femoral neck (FN), lumbar spine (LS), and distal radius (DR), and their medical history and risk factors were assessed through a detailed questionnaire. The FRAX® (Fracture risk assessment tool) [...]

by Antonela G. Garzón  , Micaela Albarracín  and Silvina R. Drago

Received: 08 May 2023;  Published: 22 August 2023;  doi: 10.21926/rpn.2303013

Sorghum-based beverages were developed and the effects of decortication on nutritional composition and biofunctional properties after a simulated gastrointestinal digestion were analyzed. For that, white sorghum flours from whole (WS) and decorticated (DS) grains were obtained and used to prepare sorghum beverages. They were analyzed regarding chemical composition, minerals, and phenolic acid contents. Moreover, the bioaccessibility of phenolics, proteins, and the potential bioactivity (ABTS+ scavenging, ACE-I inhi [...]

by Ron Dolgin  and Matthew J. Davis

Received: 20 March 2019;  Published: 18 June 2019;  doi: 10.21926/obm.icm.1902037

Integration of behavioral health consultants and specialists into medical settings has accelerated the development of evidenced-based practices for an array of problems and concerns common to behavioral medicine. Though these treatments have shown to be beneficial for those that engage in protocols, attrition remains high. With an emphasis in directed problem solving and skill building, many brief treatments leave little room for compassion, validation, and understanding. This article explores this trend and advoca [...]

by Glauce Kelly Silva do Nascimento  , Tatiane Monteiro dos Santos  , Irene Andressa  , Vivian Machado Benassi  , Nathalia de Andrade Neves  and Marcio Schmiele

Received: 08 May 2024;  Published: 05 September 2024;  doi: 10.21926/rpn.2403013

Bread stands out for its versatility and accessibility, appealing to individuals across various ages and social classes. Consequently, it presents an attractive opportunity for incorporating ingredients that offer health benefits to consumers. In this context, the current study aimed to evaluate the technological properties of sandwich bread (specific volume, water activity, moisture, instrumental color, and texture) prepared with a partial substitution (5% w/w) of wheat flour (WF) with purple corn cob flour (PCF) [...]

by Emma Maloney  , Clodagh Dowling  , Tara Deehan  and Gary O' Reilly

Received: 29 July 2022;  Published: 18 November 2022;  doi: 10.21926/obm.icm.2204051

To compare client response to a 3-stage phased intervention for complex trauma, comparing (1) those who received face-to-face intervention with (2) those who received a hybrid of face-to-face moving mid-therapy to online intervention with (3) those who received online only. Comparing quantitative and qualitative outcome data from 3 consecutive groups (N=22) who participated in a 3-stage phased intervention for complex trauma (1) face-to-face intervention (n=7); (2) a mix of face-to-face and online intervention (n=6 [...]