by Negar Noorbakhsh  , Mina Zamani  , Alireza Sedaghat  , Jawaher Zeighami  , Farangis Foroughi Behbahani  , Sahere Parvas  , Alihossein Saberi  , Mohammad Hamid  , Roya Ghanavati  , Gholamreza Shariati  and Hamid Galehdari

Received: 11 October 2022;  Published: 12 May 2023;  doi: 10.21926/obm.genet.2302181

Familial Mediterranean Fever (FMF) is classified as an autoinflammatory genetic disease inherited by mutations in MEFV. These mutations can affect the dysregulation of inflammatory processes in the human body and lead to fever and pain in the chest and abdomen. Many known missense mutations in MEFV are linked to FMF disease. Mutations in MEFV in most cases are located on the short arm of chromosome 16 and can impair the function of the pyrin protein. In this research, we aimed to examine the entire exons of MEFV fo [...]

by Jill Gualdoni  , Jeff Ritzenthaler  , Ibrahim Elkhawas  , Gerene Bauldoff  , David Nunley  and Jesse Roman

Received: 29 November 2018;  Published: 20 February 2019;  doi: 10.21926/obm.transplant.1901051

Background: Gastroesophageal reflux disease has been associated with the development of chronic lung allograft dysfunction following lung transplantation. While the mechanisms are unclear, it is postulated that microaspiration of gastrointestinal material (GIM) leads to inflammation and airway remodeling that culminates in obliterative bronchiolitis. As the expression of the matrix glycoprotein fibronectin has been shown to be an early marker of this fibroproliferative process, its induction could suggest a causal [...]

by Katie Conlon

Received: 04 September 2023;  Published: 04 January 2024;  doi: 10.21926/aeer.2401002

Unsustainable material extraction, use and disposal - the ‘take-make-waste’ model - places communities globally in a state of social inequalities and environmental conflict (the slow violence of polluting the air, water, and soil we all depend). Current waste management practices are designed for efficiency of disposal but do not address increasing waste generation and waste externalities. The present global waste situation is magnified by exponential increases in plastic production; misconceptions of recycling; an [...]

by Inmaculada Zarzo  , Nadia San Onofre  and Jose M. Soriano

Received: 17 November 2023;  Published: 03 April 2024;  doi: 10.21926/rpn.2402005

The relationship between obesity and weight loss treatments has run parallel throughout history; however, not all diets are suitable for improving one’s health. This review aims to categorize diets according to the new classification of hazardous diets established in 2021. A search was conducted across grey, white, and black literature. The results reveal a study of 179 diets, of which 35 are effective, while the rest are hazardous to health. Looking at the geographical distribution of these diets, the USA, the UK, [...]

by Rodrigo Alvaro Brandão Lopes-Martins  , Patrícia Sardinha Leonardo  and Kevin Mannoia

Received: 04 March 2025;  Published: 18 June 2025;  doi: 10.21926/obm.icm.2502025

This article examines the complex relationship between the autonomic nervous system, the prefrontal cortex, and spiritual life, providing an interdisciplinary analysis in light of Galatians 5:16-25. Through a combination of theological reflection and insights from neuroscience, it explores how spiritual practices, such as meditation and prayer, influence emotional regulation, impulse control, and overall well-being. Studies in neuroscience have shown that regular spiritual practice can lead to measurable changes in [...]

by Gretchen Stepanovich  and Steven M. Donn

Received: 19 April 2021;  Published: 13 August 2021;  doi: 10.21926/obm.hg.2103060

Infants admitted to Neonatal Intensive Care Units (NICUs) are among the most vulnerable patients in medicine and are at risk for a variety of morbidities, many of which require pharmacologic therapy. Gastroesophageal Reflux Disease (GERD) is a common diagnosis in the NICU patient population and may or may not represent a truly pathologic process. Regardless, pharmacologic therapy is provided to many infants, who are already exposed to an inordinate number of pharmacologic agents, of which most are off label and hav [...]

by Shaymaa Azawi  , Lisa-Marie Barf  , Thomas Liehr  , Stefanie Kankel  and Martina Rincic

Received: 25 March 2022;  Published: 27 June 2022;  doi: 10.21926/obm.genet.2202159

After being established in 1967, the commercially available murine Leydig cell tumor line I-10 has been used in almost 50 published studies. I-10 has not been characterized, either at the chromosomal/ cytogenetic level or the genetic level, similar to many other murine tumor cell lines. In this study, we performed molecular karyotyping and multicolor banding-based molecular cytogenetics. A slightly hyperdiploid karyotype with 43 chromosomes was described. The main aberrations comprised several unbalanced translocat [...]

by Kamal Kant Sahu

Received: 01 November 2020;  Published: 19 November 2020;  doi: 10.21926/obm.transplant.2004126

by Antonela G. Garzón  , Micaela Albarracín  and Silvina R. Drago

Received: 08 May 2023;  Published: 22 August 2023;  doi: 10.21926/rpn.2303013

Sorghum-based beverages were developed and the effects of decortication on nutritional composition and biofunctional properties after a simulated gastrointestinal digestion were analyzed. For that, white sorghum flours from whole (WS) and decorticated (DS) grains were obtained and used to prepare sorghum beverages. They were analyzed regarding chemical composition, minerals, and phenolic acid contents. Moreover, the bioaccessibility of phenolics, proteins, and the potential bioactivity (ABTS+ scavenging, ACE-I inhi [...]

by Jeggathishwaran Panisilvam  , Peng Cheng Wang  and Hui An

Received: 26 March 2022;  Published: 13 July 2022;  doi: 10.21926/jept.2203024

Reducing and conserving fuel usage is pivotal for any engineering system for the development of a sustainable energy solution. Proton exchange membrane fuel cells (PEMFCs) are one of the promising renewable energy systems that consume hydrogen as their source of fuel to generate electricity. This paper investigate the necessity of the constant supply of fuel (hydrogen) in the PEMFC system to ensure stable operation. We propose that a dynamic supply of fuel could help achieve similar performance and reduce the amoun [...]