by Alyson Holland  and Amanda Lorbergs

Received: 29 October 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904093

Beliefs about the daily experience of a disease are used to identify risk and motivate participation in prevention. For osteoporosis, a disease that is affected by health behaviours throughout the lifecourse, individual perceptions of the disease can affect health decisions and future disease prevalence. Understanding how the experience of osteoporosis is perceived by women at different stages of life can illuminate factors that influence engagement in prevention. Women representing three life stages - young adults [...]

by Sandra Mikhael  , Maria Shawky  , Gulraiz Hashmi  , Ivan Bernal  and Roger A. Lalancette

Received: 28 June 2020;  Published: 23 July 2020;  doi: 10.21926/acr.2003006

It is historically interesting to note that, whereas the [Co(NH3)6]3+ cation was isolated by Tassaert in 1798 (which he described as the tri-chloride) and that, in the early days of Coordination Chemistry, Jørgensen and Werner isolated many of its other salts, the fluoride was never reported. In fact, in relatively modern times, lack of success was, invariably, the result of attempting its isolation and full characterization. Significantly, there is no entry for its structure in standard sources such as Inorganic C [...]

by Srinivasan Periasamy  , Se-Ping Chien  , Chen Hsu  , Dur-Zong Hsu  and Ming-Yie Liu

Received: 10 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.hg.2002047

Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hyperglycemia and diabetes. We studied the role of metformin in reversing sleep deprivation-induced hyperglycemia and pancreatic and liver dysfunction in mice. Mice were kept in cages and fed water and food ad libitum. Mice wer [...]

by Sai Batchu  , Michael Joseph Diaz  , Keldon Lin  , Namrata Arya  , Karan Patel  and Brandon Lucke-Wold

Received: 04 September 2022;  Published: 20 February 2023;  doi: 10.21926/obm.neurobiol.2301157

Pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors comprising numerous subtypes whose metabolic profiles have yet to be fully examined. The present in silico study analyzed single-cell expression profiles from 2311 PitNET cells from various lineages and subtypes to elucidate differences in metabolic activities. Gonadotroph tumors exhibited high activities with histidine metabolism, whose activity is low in lactotroph tumors. Somatotroph tumors enriched for sulfur and tyrosine metabolism, while [...]

by Aaryan Gupta  , Arpita Roy  , Soumya Pandit  , Neha Pandey  and Sarvesh Rustagi

Received: 07 July 2023;  Published: 09 October 2023;  doi: 10.21926/obm.neurobiol.2304186

Multiple Sclerosis (MS) spreads rapidly across the globe, causing almost 2.8 million cases worldwide. Many drugs and inhibitors, such as dronabinol and nabilone, have been used to treat MS, but there is no effective treatment for MS till now as these medications can cause severe side effects. So, we tested different compounds from Ginkgo biloba to inhibit the symptoms caused by MS as an herbal treatment. We targeted the Crystal structure of Myelin Oligodendrocyte Glycoprotein as it has shown some excellent results [...]

by Emma Maloney  , Clodagh Dowling  , Tara Deehan  and Gary O' Reilly

Received: 29 July 2022;  Published: 18 November 2022;  doi: 10.21926/obm.icm.2204051

To compare client response to a 3-stage phased intervention for complex trauma, comparing (1) those who received face-to-face intervention with (2) those who received a hybrid of face-to-face moving mid-therapy to online intervention with (3) those who received online only. Comparing quantitative and qualitative outcome data from 3 consecutive groups (N=22) who participated in a 3-stage phased intervention for complex trauma (1) face-to-face intervention (n=7); (2) a mix of face-to-face and online intervention (n=6 [...]

by Thales Almeida Barbosa  , Marcelo Costa Flores  and Katia Cecília de Souza Figueiredo

Received: 09 May 2022;  Published: 16 August 2022;  doi: 10.21926/aeer.2203030

Mixed matrix membranes (MMMs) consist of a polymeric phase and a dispersed solid filler such as zeolites or carbon nanotubes. We prepared symmetric and asymmetric polysulfone-based MMMs containing functionalized multi-walled carbon nanotubes (MWNT-O) for CO2/N2 separation. Maxwell’s model was used to predict the permeabilities of MMMs. The permeability achieved using the model exhibited a good fit of the model in symmetric MMMs, especially for CO2. This can be potentially attributed to the high affinity of th [...]

by Anita Modi  and Sherif Beniameen Mossad

Received: 07 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.transplant.1903085

Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of malignancy has led to markedly reduced tumor burden and improved patient survival, sparking curiosity about their potential role in the treatment of other chronic inflammatory states, including infectious diseases. While [...]

by Albena Staynova  , Ljubomira Hadjiiska  , Valeria Hadjidekova  and Rositsa Hristova

Received: 14 August 2018;  Published: 22 October 2018;  doi: 10.21926/obm.genet.1804043

Background: The purpose of study was to assess the cytogenetic effect of chronic low dose radiation exposure of nuclear power plant workers using the micronucleus centromere assay. This method allows the differentiation between centromere-positive micronuclei containing whole chromosome and centromere-negative micronuclei containing acentric fragment pointing to clastogenic action of ionizing radiation. Methods: The effect of low dose occupational exposure was estimated in 32 nuclear power plant workers using in si [...]

by Laura Borth  and Meredith Ponder Whitmire

Received: 31 March 2023;  Published: 17 August 2023;  doi: 10.21926/obm.geriatr.2303246

Malnutrition is a problem that is often not identified in hospitals as 8% of hospital patients are diagnosed but malnutrition is estimated to affect 20-50% of patients. Federal programs such as Joint Commission accreditation and the new, optional, global malnutrition composite score from CMS may improve inpatient malnutrition diagnosis, but there may be an opportunity to do more from a regulatory side. It’s unknown how many states are considering malnutrition from this standpoint. The study’s goal was t [...]