by Anita Padmanabhanunni  , Serena Ann Isaacs  , Tyrone Pretorius  and Brendon Faroa

Received: 30 April 2022;  Published: 15 August 2022;  doi: 10.21926/obm.neurobiol.2203130

Fear has been the most common emotional response to the COVID-19 pandemic, and excessive fear is associated with various indices of psychological distress, particularly loneliness. Although most people have experienced pandemic-related fear and distress, certain groups who are on the front of service provision have experienced the pandemic in distinct ways, owing to its impact on the nature of their work. Schoolteachers represent one such group; therefore, it is imperative to identify resources that can safeguard a [...]

by Adam G. Evans  , Brady L. Burns  , Maryo M. Ibrahim  , Tigran Kesayan  , Krista N. Brooks-Horrar  , Patrick E. Assi  , Christopher L. Kalmar  , Jeremy T. Joseph  , Hamid M. Shah  and Salam Al Kassis

Received: 14 November 2022;  Published: 23 May 2023;  doi: 10.21926/obm.neurobiol.2302170

Migraines affect approximately one billion individuals worldwide. Implanted nerve stimulator devices can provide relief to some individuals who have chronic migraines refractory to other treatments. This study defines the change in headache pain severity and headache frequency following implanted nerve stimulator treatment in chronic migraineurs. A PRISMA-compliant systematic review of six databases was performed to identify all clinical trials treating at least 10 chronic migraineurs with an implanted nerve stimul [...]

by Ivan M. Lang

Received: 17 August 2020;  Published: 02 November 2020;  doi: 10.21926/obm.hg.2004052

Several digestive tract reflexes involving the esophagus and its sphincter muscles have been identified, but to date, no comprehensive review has addressed most of these reflexes. The current review presents the known physiology of different esophageal reflexes in which either the esophagus or its sensory or motor portion of the reflex response is elaborated. The current review comprehensively examines the known and possible mechanisms underlying major esophageal reflexes, highlights the huge gaps in current knowle [...]

by Ibrahim El-Serafi  , Sandra Oerther  , Ying Zhao  and Moustapha Hassan

Received: 08 July 2022;  Published: 27 July 2022;  doi: 10.21926/obm.transplant.2203163

Cytochrome P450 2J2 (CYP2J2) is one of the recently discovered enzymes that is involved in the metabolism of several drugs. It is mainly an extrahepatic enzyme which can, to some extent, explain some the drugs’ side effects such as cyclophosphamide (Cy). Cyclophosphamide is an alkylating agent that is commonly used in conditioning prior to stem cell transplantation. It is a prodrug that is bio-activated by several CYPs including CYP2J2. Cy is known to have several side effects and its extrahepatic activation by CYP [...]

by Kurt Grüngreiff  , Thomas Gottstein  and Dirk Reinhold

Received: 15 March 2019;  Published: 13 June 2019;  doi: 10.21926/obm.hg.1902023

Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connective tissue (scar tissue) as a consequence of chronic liver damage, is a connecting pathogenic process in all chronic liver diseases. Zinc is an essential micronutrient in human health, playing a fundamental role in cellu [...]

by Bin Ni  , Nidhi Sharma  , Ashley Rosko  , Don M. Benson  and Yvonne A. Efebera

Received: 12 April 2021;  Published: 09 July 2021;  doi: 10.21926/obm.transplant.2103148

Prior to the advent of anti-retroviral therapy (ART), autologous stem cell transplant (ASCT) was relatively contraindicated for multiple myeloma (MM) patients with human immunodeficiency virus (HIV) due to issues associated with stem cell harvest and the risk of opportunistic infections. With the widespread use of ART for control of HIV, ASCT is now the preferred treatment for relapsed lymphoma, the leading hematopoietic malignancy associated with HIV/AIDS. Hence, MM patients with HIV controlled by ART may benefit [...]

by Mª Carmen Márquez

Received: 27 March 2024;  Published: 18 July 2024;  doi: 10.21926/cr.2403009

Lipase-catalyzed hydrolysis of olive oil has been studied in the absence of emulsifier. A simple mathematical model to predict the hydrolysis rate is derived from a proposed kinetic mechanism of the reaction. The hydrolytic reaction obeys Michaelis-Menten kinetics with a simultaneous second-order enzyme deactivation. The model predictions closely agree with the experimental results.

by Sabira Sabir Ismayilova  and Sabir Qarsh Amirov

Received: 09 January 2022;  Published: 28 June 2022;  doi: 10.21926/cr.2202017

The kinetics of dearomatization of a kerosene fraction processed using a zeolite catalyst (0.9 HZSM-5) at different temperatures (160-200°C), the molar ratio between the aromatic hydrocarbons present in the kerosene fraction and n-decene (1:(0.5-4)), and the reaction time (1-3 h) were studied. Based on the obtained data, a kinetic model for kerosene dearomatization is proposed. It is assumed that the single-center Riedel mechanism is followed. The stage associated with the interaction between n-decene adsorbed on t [...]

by Niamh Flynn

Received: 01 July 2019;  Published: 26 September 2019;  doi: 10.21926/obm.icm.1903057

Hypnosis interventions consistently produce significant decreases in pain associated with a variety of chronic-pain problems (Elkins, Jensen & Patterson 2007) while neurophysiological studies have shown that specific hypnotic suggestions have clear effects on the brain and spinal cord functioning (Jensen & Patterson 2014; Flynn, 2019). Thus, it isuseful for clinicians who practise hypnotherapy to understand pain paradigms.

by Reinhard Haas  , Marina Siebenhofer  , Jakob Lederer  and Amela Ajanovic

Received: 24 June 2022;  Published: 27 September 2022;  doi: 10.21926/jept.2203030

Today, the building sector poses a major problem concerning fossil fuel energy consumption and the corresponding emissions of local pollutants and global greenhouse gases (GHG). In addition, an increasing number of people are living in urban areas, and it is becoming challenging to provide the necessary living space and energy for heating in fast-growing cities. Currently, urban areas host approximately 50 % of the global population and generate 70 % of GHG. The core objective of this study is to analyze the histor [...]