by Clément Dumont  , Madeleine Lefèvre  , Quiterie Aussedat  , Pierre-Louis Régnier  , Alexandra Masson-Lecomte  , Evanguelos Xylinas  , Hélène Gauthier  , Virginie Fossey-Diaz  , Amélie Arégui  and Stéphane Culine

Received: 23 July 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104183

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because of their perceived frailty. Therefore, in order to evaluate the effectiveness of C-NAC in elderly patients with MIBS, we retrospectively reviewed the medical files of [...]

by Anju Khairwa

Received: 14 September 2022;  Published: 22 November 2022;  doi: 10.21926/obm.genet.2204172

Cervical carcinoma is most common in Indian women of which Rural women are predominantly affected. The most common etiological factor is human papillomavirus (HPV ). The present study aims to assess the diagnostic accuracy, sensitivity, specificity, and different patterns of cervical Pap smears by comparing histological findings. The index study is a retrospective cross-sectional analytical study. The data was collected at the pathology department from May 2017 to December 2019 according to hospital ethical protoco [...]

by Rastislav Burda  , Viera Danielisová  and Jozef Burda

Received: 03 June 2019;  Published: 20 September 2019;  doi: 10.21926/obm.neurobiol.1903041

Background: Many experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. However, the translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-Methyltin (TMT) poisoning and short-term transient cerebral ischemia cause similar damage, especially, to selectively vulnerable brain regions such as hippocampal CA1 and CA3. Methods: Using dual conditioning, we activated the full [...]

by Suman Lahkar  , Richa Brahma  and Swapan Kumar Dolui

Received: 15 September 2022;  Published: 04 January 2023;  doi: 10.21926/cr.2301002

The development of noble metal-free catalyst for hydrogen evolution reaction (HER) is the primary challenge in fuel production to replace fossil fuels. Here, we have synthesized Fe-doped TiO2/PANI nanocomposite via facile in situ polymerization method and studied its electrocatalytic activity towards HER. The composite catalyzes HER efficiently with an overpotential value of -180 mV vs. RHE in 0.5 M H2SO4 solution to achieve the current density of 10 mA cm-2 and also possesses unique stability of 8 h. However, a un [...]

by Leila Naseri  , Mohsen Akbaribazm  and Mozafar Khazaei

Received: 06 February 2024;  Published: 04 July 2024;  doi: 10.21926/obm.genet.2403248

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy causing non-ovulation infertility in women. Women with PCOS have higher levels of luteinizing hormone (LH), testosterone, cholesterol and triglycerides but, in contrast, lower levels of follicular stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) compared with healthy counterparts. Because of the limitations of human studies, animal models of PCOS have been developed to identify appropriate therapeutics and to explore their mechanism [...]

by Carsten Croonenbroeck  and David Hennecke

Received: 20 July 2021;  Published: 25 October 2021;  doi: 10.21926/jept.2104044

In this study, we address the wind farm layout optimization (WFLO) problem and tackle the issue of optimal turbine placement by incorporating additional aspects of an economically driven target function. Firstly, we have analyzed the effect of wind direction on a given turbine arrangement. Based on the direction-dependent wake pattern, practitioners sometimes shut down certain turbines on their farms. Our method computes which turbines should be shut down in which wake situation. On this basis, we have developed a [...]

by Anastasia Skonta  , Elena Gkantzou  , Konstantinos Spyrou  , Stamatia Spyrou  , Angeliki Polydera  , Dimitrios Gournis  and Haralambos Stamatis

Received: 31 July 2022;  Published: 08 October 2022;  doi: 10.21926/cr.2204032

3D printed PLA has already been demonstrated for several biotechnological applications, including enzymes immobilization. The prerequisites for an efficient screening assay include using small volumes of reagents, low cost, and rapid screening of large numbers of compounds and extracts. Hence, assays based on microtiter plates are predominant. Thus, designing and fabricating scaffolds on a similar scale, which could serve as immobilization carriers, and their recruitment in inhibitors screening studies is of great [...]

by Lena Natapov  , Ayelet Berg-Warman  , Ile Kermel Schiffman  and Shlomo Paul Zusman

Received: 01 May 2022;  Published: 17 November 2022;  doi: 10.21926/obm.geriatr.2204212

To understand dental service utilization in the over-65 age group and to identify the main patterns and barriers to uptake of dental care after the 2019 expansion under the National Health Insurance Law to include dental benefits for the over-75 age group. Phone interviews with a random sample of 512 people over the age of 65 were conducted between February and April 2020. About half had visited a dentist during the previous year (an average of 2.9 visits) while 17% reported they had never visited one. Dental servi [...]

by Shashya Wijesinghe  and Elizabeta B. Mukaetova-Ladinska

Received: 03 March 2024;  Published: 10 May 2024;  doi: 10.21926/obm.geriatr.2402279

In the UK, 25,000 people from ethnic minority background live with dementia. Although dementia associated risk factors are common amongst South Asians, they tend to present at services later and when in crisis. This review explores UK South Asian communities perception of dementia to understand factors impacting their decision to seek help. Search terms assisted by the PICO strategy were inputted into five databases and ten qualitative papers identified. Meta-ethnography methodological framework was implemented for [...]

by Renata Lemonica  , Isabela Almeida Cunha  , Jéssica Layane Costa Melo  , Sandra Regina Caram  , José Eduardo Fuser Bittar  and Karina Pavao Patricio

Received: 23 March 2024;  Published: 31 July 2024;  doi: 10.21926/obm.icm.2403044

Homeopathy has shown promise in fighting epidemics, leading to potential applications in the COVID-19 clinical cases. To assess the impact of add-on individualized homeopathic medicinal products (IHMP) on improving clinical outcomes and time to medical discharge in COVID-19 patients, a prospective, double-blind, randomized, placebo-controlled, parallel-group exploratory clinical trial was conducted in a São Paulo state municipality, Brazil, between February and July 2021. 82 (unvaccinated) patients with conf [...]