by Laura Roche  , Traci Flynn  and Linda Campbell

Received: 26 September 2023;  Published: 28 February 2024;  doi: 10.21926/obm.genet.2401217

22q11.2 deletion syndrome (22q11.2DS) is a complex and widely variable genetic syndrome involving multisystem physical health problems, significant cognitive and psychosocial challenges, all of which may impact upon learning and academic achievement. In the current study, we explored mothers’ perceptions of their child’s learning within early and primary educational contexts. We conducted 3 online focus groups and 1 online semi-structured interview with a total of 9 mothers of children diagnosed with 22q11.2DS. Mot [...]

by Ethan Fitzgerald  , Dorian Mateusz Kusyk  and Nestor D Tomycz

Received: 02 December 2020;  Published: 30 April 2021;  doi: 10.21926/obm.geriatr.2102170

Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Dis [...]

by Laura A. Huppert  , Marie Sinclair  and Jennifer C. Lai

Received: 08 November 2018;  Published: 28 November 2018;  doi: 10.21926/obm.transplant.1804028

Background: Patients with cirrhosis suffer not only from commonly-diagnosed portal hypertensive complications such as ascites and hepatic encephalopathy but also from more insidious effects of chronic liver failure including muscle wasting, under-nutrition, and functional decline. These manifestations of physical frailty have been demonstrated to predict mortality in patients with cirrhosis independently of liver disease severity, but objective biomarkers associated with physical frailty in cirrhosis are needed. Th [...]

by Karen E. Atler  , Deana Muñoz  , Carly Knowles  , Angie Noe  , Christine A. Fruhauf  , Kathryn McGirr  , Tracy L. Nelson  and Arlene A. Schmid

Received: 18 May 2021;  Published: 05 November 2021;  doi: 10.21926/obm.icm.2104043

If proper self-management behaviors are not maintained, diabetes may lead to reduced quality of life (QoL), decreased engagement in everyday activities, disabling health complications, and even death. Less advantaged adults with limited income, lower education, and fewer resources find diabetes self-management (DSM) particularly challenging due to healthcare and social inequalities. DSM education is important to understanding diabetes-related behaviors and improving QoL. There are few evidence informed DSM educatio [...]

by Silvia Martini  , Ezio David  , Francesco Tandoi  , Dominic Dell Olio  , Antonio Amoroso  , Mauro Salizzoni  , Giorgio Maria Saracco  and Renato Romagnoli

Received: 27 September 2018;  Published: 04 December 2018;  doi: 10.21926/obm.transplant.1804030

Background: We performed a liver transplant (LT) with a graft from a 52-year-old donor of blood group O who was HCV viremic. The recipient was a 52-year-old male with blood group A, HCV-related cirrhosis and hepatocellular carcinoma. Methods: A liver biopsy performed on post-LT day 9 revealed acute T-cell-mediated rejection and the patient received three 1.0-g boluses of methylprednisolone. On day 9, the hemoglobin level dropped and the direct antiglobulin test became positive. Passenger lymphocyte syndrome (PLS) w [...]

by Thomas Liehr  , Monika Ziegler  , Nadezda Kosyakova  and Ahmed B.H. Al-Rikabi

Received: 16 March 2018;  Published: 17 May 2018;  doi: 10.21926/obm.genet.1802021

Background:Fluorescence in situ hybridization (FISH) can be performed on metaphase- and/or interphase cells. Metaphase cells can exclusively be obtained and studied after time-consuming cell culture. Therefore, this technique is suitable only for cells derived from peripheral blood, bone marrow or fibroblasts, the latter including skin, tumour or "prenatal tissues", such as the amnion or chorion. On the other hand, interphase cells can be gained from many different cells and even without cell culture. Methods:Here, [...]

by Andre Cardim de Aguiar  and Soraya Giovanetti El-Deir

Received: 09 May 2022;  Published: 20 September 2022;  doi: 10.21926/aeer.2203034

The presence of shopping malls causes a social, economic, and environmental impact. The bibliometric analysis is a valuable method used to dentify published research papers, and understand historic information published in scientific journals. This method can be used to carry out qualitative and quantitative analyses of scientific production on a specific subject. This analytical method primarily focuses on analyzing the bibliometric study of the solid waste management method used in shopping malls. A small number [...]

by Michael Frass

Received: 07 April 2018;  Published: 20 April 2018;  doi: 10.21926/obm.icm.1802004

Oncology patients often suffer from the side-effects of conventional therapy, such as chemotherapy, radiation and/or surgery. Additive complementary medicine, such as homeopathy might be beneficial in the support of these patients. Several case reports as well as some studies have suggested the beneficial effects of homeopathy in cancer patients. Furthermore, homeopathy may also be helpful in improving quality of life (QoL). Homeopathic remedies also offer the advantage that they can be combined with a variety of c [...]

by Y. Ben-Aryeh

Received: 29 July 2019;  Published: 04 September 2019;  doi: 10.21926/rpm.1903003

In this article, microsphere super-resolution, which are beyond the Abbe classical limit, are described. The conversion of evanescent waves into propagating waves is analyzed by using the geometry of the microsphere. In microsphere experiments, a nanojet is produced near the focal plane, where its width is smaller than the Abbe limit and remains unchanged in the axial direction for certain wavelengths. The interference between the evanescent waves being converted into propagating waves and the nanojet leads to an i [...]

by Gregory R. Goodwin  , Narges Sadat Shamabadi  , Pratima Pandey  , Ewen McLean  and Omar Bagasra

Received: 26 September 2020;  Published: 07 June 2021;  doi: 10.21926/aeer.2102011

Regressive Autism [RA] is a subtype of autism spectrum disorder (ASD) that manifests as the loss of previously acquired developmental milestones and skills. Early life dysregulation of neurodevelopment due to exposure to toxic metals has been associated with ASD, but the underlying biological mechanisms by which metals influence neurodevelopment remain unclear. We explored the potential role of thimerosal or ethylmercury on neurite formation and oxytocin receptor (OXTR) modulation in four human-developing neuronal [...]