by Pavel Kalvach  and Martin Vogner

Received: 30 March 2019;  Published: 08 July 2019;  doi: 10.21926/obm.geriatr.1903060

The understanding of mental deterioration associated with old age has undergone several changes over the past two centuries, and has spurred major scientific debates. In the 19th century, this disorder was still considered an inevitable part of aging. The beginning of the 20th century offered a histological explanation for presenile dementia, and Alois Alzheimer was credited as the discoverer of a new disease that bears his name to date. In the last quarter of the 20th century, findings of Alois Alzheimer were appl [...]

by Jean Golding  , Rosie Clark  , Steven Gregory  , Genette Ellis  , Matthew Suderman  , Yasmin Iles-Caven  and Marcus E. Pembrey

Received: 17 May 2021;  Published: 29 October 2021;  doi: 10.21926/obm.genet.2104141

The FRAXE section of the FMR2 gene, located on the X chromosome, contains varying numbers of trinucleotide repeats; boys with over 200 repeats tend to have mild cognitive impairments, though this is rare. Little is known, however, concerning the phenotypes of individuals with smaller numbers of repeats. Here we answer the research question as to whether the health of ancestors of boys from whom the relevant X chromosome was inherited differed in any way according to the number of FRAXE repeats. Numbers of FRAXE rep [...]

by Arlene A. Schmid  , Marieke Van Puymbroeck  , Christine A. Fruhauf  , Laura A. Swink  and Jennifer D. Portz

Received: 29 September 2019;  Published: 25 November 2019;  doi: 10.21926/obm.geriatr.1904087

Background: Falls are relatively common in older adults and are associated with chronic pain. Chronic pain may even be a predictor of falls in older adults. However, this relationship has not been studied in adults

by Susanna Lam  , Jerome M Laurence  and Deborah J Verran

Received: 01 July 2019;  Published: 08 October 2019;  doi: 10.21926/obm.transplant.1904087

A range of corrective surgical procedures may be required in adult renal transplant recipients who sustain loss of integrity of the abdominal wall in the first month postoperatively. Where this involves the fascia, such as in acute fascial dehiscence or in renal allograft compartment syndrome, more sophisticated reconstructive procedures may also be required, particularly in the setting of surgical site infection. There is limited data on the use of prosthetic or biologic mesh for this type of scenario, where urgen [...]

by Atena Samarehfekri  , Mohammad Ali Zakeri  , Hemn Kaka Mirza  , Adnan Rashid Aziz  and Mahlagha Dehghan

Received: 21 December 2022;  Published: 02 June 2023;  doi: 10.21926/obm.transplant.2302186

Foot reflexology has improved numerous physical and psychological symptoms in patients. The researchers in this study aimed to investigate the effect of foot reflexology on laboratory parameters, intake/output/weight and medication regimen after kidney transplant surgery. The research was a secondary analysis of a parallel randomized controlled trial. The research included patients who were admitted to the transplantation ward. The stratified randomization approach divided 53 eligible patients into two groups: foot [...]

by Diego A. Bonilla

Received: 21 December 2022;  Published: 26 December 2022;  doi: 10.21926/obm.icm.2204056

Anthropometric measurements are frequently used to assess changes in body composition in different populations. Despite being a cheap, in-field, and relatively valid technique, the COVID-19 pandemic has impulse research on digital anthropometry across the globe. Machine learning, as the convergence of artificial intelligence and data mining, has the potential to improve data collection and analysis in the applications of kinanthropometry. Far from replacing conventional methods, digital anthropometry is a powerful [...]

by Oya M. Andacoglu  , Jack Liu  , Abigail L. Brooks  , Amit Blumfield  , Mehul Trivedi  , Shoshana Lehman  , Michael K. Parides  , Enver Akalin  , Jay A. Graham  , Juan P. Rocca  and Stuart M. Greenstein

Received: 17 March 2021;  Published: 20 July 2021;  doi: 10.21926/obm.transplant.2103150

Glomerular filtration rate (GFR) is an excellent indicator of renal function; however, it is rarely evaluated as an endpoint. We investigated donor and recipient factors for associations that might be predictive of mid-term GFR after renal transplantation. We performed a retrospective review of 828 deceased donor renal transplantations performed at Montefiore Medical Center between the years 2009-2015. Donor characteristics included KDPI, [low (<20%), medium (20-80%), high (>80%)], age, graft types [extended [...]

by Wolf-Dieter Heiss

Received: 02 July 2018;  Published: 19 September 2018;  doi: 10.21926/obm.neurobiol.1803011

Gliomas originating from glial cells comprise about 30% of all primary central nervous system tumors and 80% of malignant brain tumors. Gliomas differ in their biological activity and are categorized according to grades, from benign to malignant with high recurrence rates. For diagnosis, location and extent of the tumor is assessed by CT and MRI, but for grading, additional parameters are necessary: contrast enhanced CT and MRI reveal damage of the blood–brain barrier, perfusion-weighted MRI shows regional blood su [...]

by Kiril Fedorov  , Sonia Sheikh  , Alex Romaschin  and Michael Thompson

Received: 03 May 2020;  Published: 18 August 2020;  doi: 10.21926/rpm.2003019

During a variety of medical procedures such as renal dialysis, bypass surgery, and lung transplantation patient blood is exposed to the surface of a number of polymeric materials such as polycarbonate (PC), poly (vinyl chloride) (PVC) and polysulfone (PS) for a period up to several days. Such exposure may result in undesirable protein-material interactions that can potentially trigger deleterious biological processes including thrombosis, which may be responsible for other complications such as cognitive disability [...]

by Keith D Hutchison  and Barbara Iisager

Received: 13 September 2020;  Published: 24 November 2020;  doi: 10.21926/aeer.2004004

The processes relevant to the verification of cloud forecasts generated by climate models are discussed from an engineering perspective. These processes include an assessment of cloud product requirements to be evaluated, the creation of a verification test plan including procedures and data to be analyzed, the development of independent sources of validation or truth datasets, and the quantitative comparisons between the cloud forecast products and the truth data needed to establish model performance. The engineer [...]