by Behzad Foroutan

Received: 02 January 2023;  Published: 03 July 2023;  doi: 10.21926/obm.genet.2303185

The main purpose of this paper was to generate a narrative review related to the current knowledge of the TP53 gene and its product, the p53 protein. It was also attempted to elucidate the different p53 reactivation strategies of great interest, as various small molecules are being studied to reactivate mutant p53. PubMed and ScienceDirect were searched for p53, mutant p53, and wild-type p53 limited by the title filter through the end of 2022. The collected articles were studied, evaluated and summarized. In the sh [...]

by Stephanie Brown  , Catherine L Wall  , Chris Frampton  , Richard B Gearry  and Andrew S Day

Received: 11 February 2023;  Published: 29 June 2023;  doi: 10.21926/rpn.2302009

The low FODMAP diet (LFD) is a dietary intervention developed for and used particularly for the management of functional GI symptoms (FGIS) in adults with irritable bowel syndrome (IBS). It has also been proposed to improve coincident functional gut symptoms in adults with inflammatory bowel disease (IBD). This report describes the outcomes of the LFD in a series of children with IBD with concurrent FGIS. This study included children aged between 7-14 years with quiescent IBD and overlapping FGIS. All participants [...]

by Zahra Iran Pour Mobarakeh  , Mansoureh Nickbakht  , Susan Sabbagh  , Maryam Khorramizadeh  and Marzieh Amiri

Received: 02 January 2023;  Published: 29 June 2023;  doi: 10.21926/obm.genet.2302184

Congenital hearing loss can have a long-term impact on children’s speech and communication abilities. Early detection and intervention of hearing loss are important in newborns. It is well known that there are several risk factors for hearing loss; however, the relationship between these risk factors and hearing screening tests remains uncertain in Iran. Therefore, this study aimed to explore the relationship between hearing loss risk factors and Automated Auditory Brainstem Response (AABR) and Transient-Evok [...]

by Journal of Energy and Power Technology Office

Received: 25 June 2023;  Published: 28 June 2023;  doi: 10.21926/jept.2302021

by Deepti Singh Chalia  , Anil Khurana  , Mehul Trivedi  , Pinaken Trivedi  , Sarita Gola  and Parul Singh

Received: 20 February 2023;  Published: 28 June 2023;  doi: 10.21926/obm.icm.2302025

This retrospective data analysis study aims to analyze the data collected during adjunctive homeopathy treatment of COVID-19 patients by the Homoeopathic medical officers (HMO) in Gujarat state-dedicated COVID-19 hospitals (DCH) during the first wave of the pandemic. The HMOs used the standard data collection forms/sheets to record each patient's demographic information, clinical symptoms, homoeopathic management, and outcome data. Data of all cases hospitalized with COVID-19 of any age, and both genders were i [...]

by OBM Geriatrics Editorial Office

Received: 25 June 2023;  Published: 27 June 2023;  doi: 10.21926/obm.geriatr.2302241

InterviewAn Interview with Dr. Ines TestoniOBM Geriatrics Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: geriatrics@lidsen.comOBM Geriatrics 2023, volume 7, issue 2 doi:10.21926/obm.geriatr.2302241Received: June 25, 2023Accepted: June 26, 2023Published: June 27, 2023

by Mauro Turrin  , Lucia Fornasiero  and Antonio Navarro

Received: 08 January 2023;  Published: 27 June 2023;  doi: 10.21926/obm.geriatr.2302240

We describe the clinical case of a 74-year-old male patient who received the second Comirnaty/Pfizer anti-COVID-19 vaccine dose. After 3 weeks he showed the clinical signs of polymyalgia rheumatica. The history included mild chronic normocytic normochromic anemia and hypogammaglobulinemia, osteoarthritis disease, livedo reticularis, hypercholesterolemia, and arterial hypertension. Despite prolonged treatment with NSAIDs and dexamethasone, the disease evolved into remitting seronegative symmetrical synovitis with pi [...]

by Michael B. Keller  , Temesgen E. Andargie  and Sean Agbor-Enoh

Received: 16 March 2023;  Published: 26 June 2023;  doi: 10.21926/obm.transplant.2302190

Advances in the use of molecular biomarkers to guide management of lung transplant recipients are emerging. One such biomarker, donor-derived cell-free DNA (dd-cfDNA), has the potential to alter traditional approaches of lung transplant management, including the detection of acute rejection or infection, surveillance monitoring strategies, risk stratification of vulnerable patient populations and molecular phenotyping of various forms of allograft injury. The emergence of novel genetic and epigenetic approaches uti [...]

by Xiaoli Li  , Kendall Brune  , Jean Keller  , Jennifer Stelter  and Stan Ingman

Received: 23 August 2022;  Published: 25 June 2023;  doi: 10.21926/obm.geriatr.2302239

Residents’ activity is a strong contributor to the quality of life in long-term care facilities. Hence, activity professionals have an essential role to play in enhancing residents’ activity engagement. Professional practice model for activity professionals includes Assessment, Planning, Implementation, and Evaluation (APIE model). Although activity professionals have made advances in demonstrating their value, few studies have focused on the APIE model for activity professionals in long-term care facilities. A sur [...]

by Vardan Apinyan

Received: 30 March 2023;  Published: 24 June 2023;  doi: 10.21926/rpm.2302026

This paper considers a finite-sized two-leg ladder of spin-1/2 particles with local inter-chain Ising interaction. We include the effects of an external magnetic field by incorporating a Zeeman-type coupling between the magnetic field and the spins localized on the lattice sites. To analyze the system, we utilize the transfer-matrix formalism to calculate the partition function. We compute the magnetization for different configurations by varying the system's parameters. We observe the presence 3of spontaneous magn [...]