Islet Transplantation: How Much Have We Advanced and How to Keep Moving Forward?
Abstract
(ISSN 2577-5820)
OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.
We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 8 days from acceptance to publication (median values for papers published in this journal in 2021, 1-2 days of FREE language polishing time is also included in this period).
Special Issue
Current Advancement of Islet Cell Transplantation in the Treatment of Diabetes Mellitus
Submission Deadline: September 30, 2018 (Open) Submit Now
Guest Editor
Kenneth L. Brayman, MD, PhD, FACS
Professor of Surgery, Medicine, and Biomedical Engineering, Director of Kidney, Pancreas and Islet Transplant Programs, Director of Center for Cellular Therapy and Biologic Theraputics. Department of Surgery, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA
Research Interests: transplant immunosuppression, chronic allograft nephropathy, solid organ transplantation in patients with HIV, islet cell transplantation, transplantation tolerance, gene therapy and xenotransplantation
About This Topic
OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation. This is seeking original manuscripts for a Special Issue on cell-based therapy for diabetes: “Current Advancement of Islet Cell Transplantation in the Treatment of Diabetes mellitus” scheduled to appear in the first half of 2018.
Islet transplantation and pancreas transplantation have been becoming promising therapies for diabetes, which can restore normal blood glucose and prevent diabetes complications. However, there are many grand challenges for maintaining long-term graft function and insulin independence in diabetes patients.
The special issue will provide a forum for presenting current research works and clinical results showing advancement of cell-based therapy for diabetes, including auto-transplantation, all-transplantation, inflammatory reaction involved islet transplantation, islet macro and microencapsulation, stem cell therapy, as well as in vitro and in vivo imaging of the islets. The special issue will also be open to any author, but mainly invited by guest editor. Each submission will be reviewed by at least two reviewers to ensure a very high quality of papers selected for the Special Issue.
Publication
Islet Transplantation: How Much Have We Advanced and How to Keep Moving Forward?Abstract EditorialIslet Transplantation: How Much Have We Advanced and How to Keep Moving Forward?Braulio A. Marfil-Garza 1, Tatsuya Kin 1, 2, * [...] |
Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Functionby
![]() ![]() Abstract Islet transplantation is a promising technique for millions of patients with diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including donor metabolic function, age, and comorbidities. The impact of these diverse factors on islet health have led [...] |
Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research PancreasesAbstract Background This presentation of a six-year study processing human islets for research and transplantation includes a review of multi-center transplant studies identifying key variables critical for successful islet processing and defines standardized processing procedures required to provide highly purified, functional Human Islets.
Methods [...] |
Targeting Acute Islet Inflammation to Preserve Graft Mass and Long-Term FunctionAbstract Islet transplantation is a minimally invasive cell based replacement therapy to prevent or reverse diabetes or hypoglycemia through natural hormonal responses to regulate blood glucose. However, extending the islet graft functional lifespan remains a challenge that prevents long-term success and widespread use of the procedure. Islets are [...] |
Where’s Waldo? Extrahepatic Site Options for Islet Transplantationby
![]() ![]() ![]() ![]() ![]() ![]() Abstract The current predominant location for allo- and auto-transplantation of islet cells is into the liver via the portal venous system. Despite the relative success of this site over the last several decades, further study has revealed multiple disadvantages. Portal hypertension, portal vein thrombosis, bleeding, low oxygen tension, instant blood [...] |
Chemical Strategies for Improving Islet Transplant Outcomesby
Abstract Islet transplantation has proven to be a viable treatment for individuals suffering from both Type 1 Diabetes Mellitus (T1D) and chronic pancreatitis. However, a variety of challenges limit the effectiveness of this procedure by reducing the number of islets that survive the harvesting and transplantation processes. Increasing islet survival [...] |
Application of Microfluidic Biochips for Human Islet TransplantationAbstract In this review, we discuss the application of microfluidic devices in studying the physiology and pathophysiology of human islets and beta-cells, especially its application for human islet transplantation. Human islet transplantation is a promising therapy for Type I diabetes; however, the islet transplant outcomes for achieving complete insul [...] |
Evolution of Enzyme Requirements for Human Islet IsolationAbstract Islet transplantation is becoming an established treatment option for managing a subset of adult patients who have type 1 diabetes mellitus. The success of this procedure is dependent upon the recovery of a sufficient number of functional human islets from donor organs for subsequent transplant. Here, the use of optimized bacterial collagenase [...] |
Role of Automated Insulin Delivery (Artificial Pancreas) in Islet Transplantation: An In Silico AssessmentAbstract Human pancreatic islet transplantation is a minimally-invasive procedure that is gaining recognition for the treatment of type 1 diabetes (T1D). Selected patients with unstable T1D, hypoglycemia unawareness, history of severe hypoglycemia, and glycemic lability, not successfully stabilized with intensive insulin treatment, can be offered this [...] |
Intrapancreatic Parenchymal Cell Transplantation as a Possible Model for the Development of a Cell-based Therapy for Type I Diabetes MellitusAbstract (1) Background: Transplantation of isolated islets is one of the most powerful approaches to cure insulin-dependent (type I) diabetes mellitus (IDDM). Currently, the most widely used transplantation strategy is percutaneous perfusion into the liver via the portal vein. However, this approach has several drawbacks and is often limited by the [...] |
Autoimmunity in Autologous Islet Transplantationby
![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract Total pancreatectomy (TP) is increasingly being utilized for definitive treatment in patients with debilitating chronic pancreatitis (CP). In an effort to prevent surgical diabetes, the procedure can be performed in conjunction with transplantation of islets of Langerhans recovered from the patients’ own resected pancreas (autologous islet [...] |
Regulation of Inflammatory Response in Islet Transplantationby
![]() ![]() Abstract Islet cell transplantation is a developing treatment for patients suffering from severe Type-1 diabetes. The long-term insulin independence after islet cell transplantation has been difficult to achieve, and this has been linked to several factors. One of the major cause of poor long-term outcome is inflammation surrounding the islets. Inflamm [...] |
Delayed Clinically Significant Portal Hypertension after Total Pancreatectomy-Islet Auto-TransplantationAbstract Portal hypertension has not been described as a complication of total pancreatectomy-islet auto-transplantation (TPIAT). We describe the first reported case of delayed and clinically significant portal hypertension following TPIAT in a patient with idiopathic chronic pancreatitis. |
Stem Cell Strategies to Promote Islet Transplantation Outcomesby
![]() ![]() Abstract Pancreas or islet transplantation is the only reliable cure for Type 1 Diabetes. However, shortage of donor tissue supply, longitudinal graft attrition due to innate and adaptive immunity and the recurrence of autoimmunity, as well as the harmful side-effects of chronic immunosuppressive therapy limit the wide-spread acceptance of islet transp [...] |
Islet Xenotransplantation for the Treatment of Type 1 DiabetesAbstract Allogeneic islet transplantation has been established to prevent severe hypoglycemia for unstable type 1 diabetic patients. Recent phase 3 clinical trial clearly demonstrated the benefit of allogeneic islet transplantation. Severe hypoglycemia is serious issue not only for type 1 diabetic patients but also type 2 diabetic patients especiall [...] |
TOP