by Danilo Donati  , Giacomo Farì  , Federica Giorgi  , Vincenza Amoruso  , Valentina Boetto  , Riccardo Marvulli  , Laura Dell'Anna  , Andrea Bernetti  and Roberto Tedeschi

Received: 31 May 2024;  Published: 10 October 2024;  doi: 10.21926/obm.neurobiol.2404248

This review examines the effectiveness of integrating botulinum toxin type A (BONT-A) with various rehabilitative strategies in treating spastic diplegia in children. The studies analyzed consistently demonstrate significant reductions in spasticity and improvements in gait when BONT-A is combined with interventions such as intensive physical therapy, serial casting, electrical stimulation, physiotherapy, occupational therapy, and robotic-assisted gait training. The findings underscore the importance of personalize [...]

by Mohammad Shabani  , Elham Hassanpour  , Fatemeh Aghighi  , Mojgan Mohammadifar  , Fereshteh Bahmani  and Sayyed Alireza Talaei

Received: 11 May 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403247

Diabetic neuropathy (DN) is a type of nerve damage caused by long-term hyperglycemia in diabetes mellitus (DM). The gut microbiota alters in DM. Therefore, improvement of the gut flora may affect neuropathic pain and oxidative biomarkers' responsiveness to the probiotic treatment. The present study aimed to assess the effects of probiotic supplementation on neuropathic pain and oxidative stress biomarkers in diabetic rats’ serum. Forty-eight rats (200-250 g) were randomly divided into four groups (n = 12 [...]

by Mahintaj Dara  , Zahra Karimi  , Mehdi Dianatpour  and Hadi Aligholi

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 21 May 2024;  Published: 18 September 2024;  doi: 10.21926/obm.neurobiol.2403245

University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantit [...]

by Manuel De Jesus Encarnacion Ramirez  , Nikolay Konovalov  , Stanislav Kaprovoy  , Gennady Chmutin  , Geovany Venegas Cerna  , Renat Nurmukhametov  , Andreina Rosario Rosario  , Kalin Ivan Yakovlevich  , Jesus Lafuente  , Eric Suero Molina  and Nicola Montemurro

Received: 20 April 2024;  Published: 09 September 2024;  doi: 10.21926/obm.neurobiol.2403244

Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucial fluorescent agent in FGS, transforming into a molecule that accumulates in tumor cells. We presented a 34-year-old female with a high-grade glioma in the left parietal lobe [...]

by Igor Val Danilov  and Sandra Mihailova

Received: 12 March 2024;  Published: 28 August 2024;  doi: 10.21926/obm.neurobiol.2403243

This pilot study (N = 28) aims to develop universal computer-aided empathy training. The experiment tests a research design of manipulating behavior in subjects toward non-affective cues in a bioengineering system. The study implements the Mother-Fetus Neurocognitive Model to involve subjects in subliminal cognitive collaboration with confederates, which enables subjects to associate the meaning of empathy with the picture only seen by confederates. The outcome shows the feasibility of the chosen research design wi [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 12 May 2024;  Published: 19 August 2024;  doi: 10.21926/obm.neurobiol.2403242

In the present era of digitalization, technology plays a prominent role in relaxation and brain development (BD), specifically for university students. The present study explores the impact of technology use and digital characteristics (DC) in developing students' BD. We applied the quantitative methods; the study collected 328 samples from Egypt's different public sector universities through a questionnaire. Using path analysis through analysis of moment structures (AMOS), the results demonstrate a positive effect [...]

by Nadia A. Abdelmegeed Abdelwahed

Received: 01 April 2024;  Published: 19 August 2024;  doi: 10.21926/obm.neurobiol.2403241

Nowadays, mental health disorders have become a significant concern for everyone. There are diverse reasons emanating from the workplace, business, and everyday environment. Therefore, there is a current need to use technology to detect and review their symptoms and causes. Accordingly, in this study, the researcher attempted to recognize ChatGPT’s role in decision-making and the recognition of mental health disorders among Egyptian entrepreneurs. The researcher used a quantitative approach in this study based its [...]

by Anna Passaro  , Antonio Zullo  , Mariacarla Di Gioia  , Mirella Dragone  , Khalida Akbar  and Fabrizio Stasolla

Received: 30 May 2024;  Published: 15 August 2024;  doi: 10.21926/obm.neurobiol.2403240

The management and treatment of challenging behaviors in children diagnosed with Autism Spectrum Disorder (ASD) is a priority for caregivers, educators, and healthcare professionals. This selective review examined how different technologies were used to help manage challenging behaviors in children with autism, describing each technology's strengths, weaknesses, and applications. This paper aimed to provide accessible choices for caregivers, educators, and healthcare professionals, enabling them to make well-inform [...]

by Roberto Anaya-Fernández  , Roberto Anaya-Prado  , Michelle M. Anaya-Fernández  , Miguel A. Guerrero-Palomera  , Ivan F. Garcia-Ramirez  , Daniel Gonzalez-Martinez  , Consuelo C. Azcona-Ramirez  , Citlalli S. Guerrero-Palomera  , Claudia Garcia-Perez  , Bernardo Tenorio-Gonzalez  , Jose E. Tenorio-Gonzalez  , Laisha F. Vargas-Ascencio  , Abraham I. Canseco-Villegas  , Gustavo Servin-Romero  , Allen R. Barragan-Arias  and Bruno Reyna-Rodriguez

Received: 02 May 2024;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403239

Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca2+-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical production via enzymes like xa [...]