by Mona-Elisa Eberharter

Received: 03 November 2025;  Published: 12 February 2026;  doi: 10.21926/obm.neurobiol.2601324

Using a two-stage qualitative design (Stage 1: expert interviews; Stage 2: biographical interviews with people with MS), existing governmental and organizational support measures for maintaining the work capacity of individuals with multiple sclerosis (MS) were analyzed, and proposals for improvement were developed. Additional state support measures were proposed, including relaxing the criteria for state assistance, creating a centralized contact point for MS-specific inquiries, and enhancing collaboration between [...]

by Fabrizio Stasolla  , Enza Curcio  , Antonio Zullo  , Mariacarla Di Gioia  and Anna Passaro

Received: 04 November 2025;  Published: 10 February 2026;  doi: 10.21926/obm.neurobiol.2601323

Mathematical learning often presents persistent challenges for children and adolescents with Autism Spectrum Disorder (ASD) due to differences in Executive Functioning (EF), cognitive flexibility, and symbolic reasoning. These factors can hinder the development of numerical understanding and pre-mathematical reasoning, problem-solving, and abstract thinking, frequently resulting in disengagement and anxiety. In recent years, digital and embodied technologies—particularly Serious Games (SG) and Educational Robotics [...]

by Mojtaba Ehsanifar  , Akram Gholami  , Nioosha Pahnavar  , Reyhaneh Shenasi  and Maryam Golmohammadi

Received: 27 October 2025;  Published: 09 February 2026;  doi: 10.21926/obm.neurobiol.2601322

Mycotoxins, toxic secondary metabolites produced by fungi and molds, have negative health impacts on both humans and animals. They are commonly found in foods such as nuts, coffee, cereals, and grains, particularly in regions with warm, humid climates. Among the most prevalent mycotoxins in these foods are aflatoxin B1, ochratoxin A, zearalenone, patulin, and deoxynivalenol (DON). The presence of mold capable of producing mycotoxins within food contributes to an elevated risk of various illnesses, including those r [...]

by Walter Paganin

Received: 30 July 2025;  Published: 27 January 2026;  doi: 10.21926/obm.neurobiol.2601321

Difficult-to-treat depression (DTD) with inflammatory features (e.g., hs-CRP ≥3 mg/L and/or elevated IL-6) may represent a clinically and biologically distinct presentation characterized by chronicity, functional impairment, prominent cognitive-motivational symptoms, and suboptimal response to conventional treatments. Classical anti-inflammatory strategies (e.g., COX-2 inhibitors or cytokine-targeting biologics) have shown signals of efficacy in selected biomarker-enriched subgroups; however, overall evidence remai [...]

by Mohsen Khosravi

Received: 19 September 2025;  Published: 26 January 2026;  doi: 10.21926/obm.neurobiol.2601320

Personalized psychopharmacotherapy remains a critical yet underdeveloped frontier in psychiatry, as traditional approaches often fail to address substantial interindividual variability in drug efficacy and tolerability. While demographic, clinical, and genetic factors have improved treatment precision, they do not fully account for observed heterogeneity. Recent advances highlight the promise of personality traits, particularly as operationalized by Cloninger’s Seven-Factor Model, as novel biomarkers for treatment [...]

by Ioannis Syros  , Anna Tsourdini  , Blossom Fernandes  and Xenia Anastassiou-Hadjicharalambous

Received: 23 September 2025;  Published: 22 January 2026;  doi: 10.21926/obm.neurobiol.2601319

Super Skills for Life (SSL) is a transdiagnostic psychoeducational program designed for children with anxiety and depressive symptoms based on cognitive-behavioral therapy. Empirically documented studies to date have demonstrated its immediate and long-term effectiveness in different contexts. The aim of this study was to assess the efficacy of the SSL program to reduce emotional and behavioral difficulties in a clinical sample of Greek-speaking primary school children aged 6 to 12. The program was implemented over [...]

by Ferydoon Khamooshi  , Samaneh Doraji-Bonjar  , Ali Reza Modarresi-Alam  and Mohammad Hasan Mohammadi

Received: 03 May 2025;  Published: 04 January 2026;  doi: 10.21926/obm.neurobiol.2601318

The study explores the crucial biological function of nitrogen in cyclic and acyclic structures with resonance potential, including tetrazoles, pyrroles, piperidines, and carbamates, within the realm of chemical neuroscience. It highlights the importance of these compounds for their biological properties and their ability to cross the blood-brain barrier (BBB) to reach the central nervous system (CNS). The study emphasizes the necessity for neurochemical drugs, like morphine, to effectively cross the BBB, as modifi [...]

by OBM Neurobiology Editorial Office

Received: 04 January 2026;  Published: 04 January 2026;  doi: 10.21926/obm.neurobiol.2601317

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2025. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of [...]

by Zekeriya Temircan

Received: 09 March 2025;  Published: 31 December 2025;  doi: 10.21926/obm.neurobiol.2504316

This study aimed to examine the psychological flexibility of individuals diagnosed with borderline personality disorder (BPD) compared to healthy controls. Psychological flexibility is a key construct related to mental health and adaptive functioning, and understanding its levels in BPD can provide insight into symptom severity and treatment outcomes. The study included 58 individuals diagnosed with BPD and 62 healthy volunteer controls, all meeting specific inclusion and exclusion criteria. Participants completed [...]

by Giustino Varrassi  , Matteo Luigi Giuseppe Leoni  , Giacomo Farì  , Annalisa Caruso  , Ameen Abdulhasan Al-Alwany  , Marco Mercieri  , Joseph V. Pergolizzi  and Rocìo Guillen

Received: 10 September 2025;  Published: 12 December 2025;  doi: 10.21926/obm.neurobiol.2504315

Chronic cancer pain results from the complex interaction of nociceptive, neuropathic, and neuroimmune mechanisms, which vary according to tumor type, location, stage, and treatment history. Recent advances in cancer neuroscience have reframed pain as a dynamic manifestation of reciprocal tumor–nerve–immune interactions, rather than a mere consequence of tissue damage. In this model, malignant, stromal, and immune cells remodel nociceptive circuits at peripheral and central levels. This narrative review, conducted i [...]