by Margaret E. Newman  , Kenneth Pursell  and David Pitrak

Received: 05 November 2018;  Published: 20 January 2019;  doi: 10.21926/obm.transplant.1901040

Infection with parvovirus B19 is common, with up to 55% of adults showing seropositive evidence of prior infection. Clinical disease can occur due to acute infection, chronic persistent viremia, rarely secondary infection, or possibly viral reactivation of latent virus. The clinical presentation of primary infection depends on age, the presence of a hematologic condition, and immune status. We report a renal transplant recipient who developed transfusion dependent anemia refractory to erythropoietin that responded [...]

by Maud Gits-Muselli  , Stéphane Bretagne  and Alexandre Alanio

Received: 04 December 2018;  Published: 17 January 2019;  doi: 10.21926/obm.genet.1901060

Pneumocystis jirovecii is an atypical fungus transmitted via the airborne route between humans. This fungus is exclusively associated with humans and almost each individual has encountered it at least once before reaching the age of two. P. jirovecii can be cleared and spontaneously resolutive in immunocompetent, whereas it can be responsible for severe Pneumocystis pneumonia (PCP) in immunocompromised patients. In the next decades, the putative increase of the population of immunocompromised patients is likely to [...]

by Andrew Villamil  , Talya Vogel  , Elli Weisbaum  and Daniel J. Siegel

Received: 03 October 2018;  Published: 16 January 2019;  doi: 10.21926/obm.icm.1901003

Research on the physiological and emotional health benefits of meditative practices has grown exponentially over the last two decades, influencing both scientific literature and popular media. Research has highlighted three distinct components or pillars at the core of meditative practices and mind training. They are, focused attention, open awareness, and kind intention. Neuroimaging studies and recent research highlight that the repeated practice of directing attention and awareness can enhance neural connections [...]

by Joep Geraedts

Received: 15 January 2019;  Published: 15 January 2019;  doi: 10.21926/obm.genet.1901059

A healthy and happy 2019

by Spinello Antinori  and Laura Milazzo

Received: 28 October 2018;  Published: 15 January 2019;  doi: 10.21926/obm.transplant.1901039

Solid organ transplantation (SOT) is increasingly employed worldwide to treat several diseases causing both acute and chronic organ failure. Recipients of SOT are at an increased risk to develop infections as a consequence of immunosuppressive therapy. Sometimes such infections may be acquired by the transplanted organ or by reactivation of a previously acquired latent infection. The globalization and the increase of international travel poses a risk for exposure to infections such as Chagas disease (CD), leishmani [...]

by Kirsten Greenlaw  and Jai Jai Shiva Shankar

Received: 07 October 2018;  Published: 13 January 2019;  doi: 10.21926/obm.neurobiol.1901019

Background: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating brain tumors and to compare it with MRP measures in the same patient population. Methods: Patients underwent CTP and MRP imaging prospectively. Images were processed with vendor-provided and vendor-neutral software. Four regions of [...]

by Elizabeth Orsega-Smith  , Stephen Goodwin  , Melissa Ziegler  , Katie Greenawalt  , Jennie Turner  and Erica Rathie

Received: 31 October 2018;  Published: 10 January 2019;  doi: 10.21926/obm.geriatr.1901029

Background: Research has shown that positive psychology interventions can enhance subjective well-being and reduce depression. However, the efficacy of these programs with older adult populations has been minimally studied. The present study studied the short and long term impact of an intervention enhancing happiness and overall mental well-being in older adults. Methods: The Art of Happiness is an 8-week program conducted at 2 senior centers in the state of Delaware. Each 90-minute class examined a different topi [...]

by Makeda L. Robinson  , Kyle Enriquez  and Dora Y. Ho

Received: 02 November 2018;  Published: 08 January 2019;  doi: 10.21926/obm.transplant.1901038

Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West Nile virus (WNV) which has become endemic in the US since its arrival in 1999 and Zika virus (ZIKV) which recently spread across the Americas. These events demonstrate the speed with which a vector-borne pathogen can disseminate when introduced into a susceptible population with [...]

by Selma A. Augusta Quist Møller  , Sohrab Sami  and Shauna L. Shapiro

Received: 04 July 2018;  Published: 06 January 2019;  doi: 10.21926/obm.icm.1901002

Background: In this study, we performed a systematic review of randomized-controlled trials (RCTs) examining the health benefits of (mindful) self-compassion-based interventions (SCBIs) and studies which explicitly combine SCBIs and mindfulness-based interventions (MBIs). Based on the compelling evidence supporting the effectiveness of MBIs, we evaluated the potential use of MBIs and SCBIs to complement one another, and whether SCBIs may serve as supplementary, or preliminary interventions for individuals not fully [...]

by Filomena Papa  , Bartolomeo Sapio  and Enrico Nicolò

Received: 31 October 2018;  Published: 04 January 2019;  doi: 10.21926/obm.geriatr.1901028

Background: Information and Communication Technologies (ICTs) have the potential to promote healthy aging and increase the quality of life of older adults. However, several barriers like access, performance, psychological, and privacy issues still exist against fully deploying ICT solutions for older adults. To determine useful methods to overcome such barriers, this work investigated the possible factors that prevent elders from directly accepting ICT services based on three field studies. Methods: The Unified The [...]

by Randye J. Semple  and Christine Burke

Received: 20 August 2018;  Published: 04 January 2019;  doi: 10.21926/obm.icm.1901001

Background: Research support for a variety of health benefits of mindfulness-based interventions for adults is robust. These include management of stress, anxiety, and depression; as a supportive treatment for eating disorders, PTSD, and psychosis; improved sleep; chronic pain management; support for tobacco, alcohol, and substance abstinence; and as adjunctive treatments for serious or chronic medical illnesses such as HIV, cancer, and heart conditions. As is typical with newer interventions, mindfulness intervent [...]

by Rahul Abhyankar  , Divya Mella  and Edward Pan

Received: 12 November 2018;  Published: 04 January 2019;  doi: 10.21926/obm.neurobiol.1901018

Objective: To report a unique case of cerebellopontine angle glioblastoma with concurrent spinal cord involvement. Background: Glioblastoma (GBM) is the most common primary malignancy of the central nervous system (CNS), comprising 46.6% of all CNS malignancies. By anatomic location, cerebellopontine angle (CPA) GBMs are exceedingly rare. To our knowledge, the following case represents the tenth reported case of CPA GBM and the first with a corresponding spinal cord tumor on presentation. Methods: Retrospective cha [...]

by Marcel Tomaszewski  and Philip Wong

Received: 22 August 2018;  Published: 03 January 2019;  doi: 10.21926/obm.hg.1901013

There is evidence to suggest that older livers regenerate less well and display cellular senescence. Additionally, elderly patients with certain liver diseases have a less favourable course. Chronic liver disease, amongst the elderly, has a significant negative effect upon quality of life and functional independence. Frailty, commonly encountered in geriatric patients, remains a significant negative predictor of physical, psychological, functional and survival outcomes in chronic liver disease. Despite advances in [...]

by David C. Gaston  and Marwan M. Azar

Received: 14 November 2018;  Published: 29 December 2018;  doi: 10.21926/obm.transplant.1804037

The approach to diagnosing fungal infections following solid organ transplantation (SOT) is patient-specific. An assessment of an individual’s risk for particular infections, also understood as the pre-test probability, should guide appropriate diagnostic testing whereas diagnostic stewardship is needed to produce interpretable, actionable and cost-sensitive results. This review provides a cognitive framework for practitioners aiming to diagnose fungal infections in recipients of SOT, taking into consideration the [...]

by Camila Sandoval  , Colleen A Lambo  and Michael Carey Satterfield

Received: 01 June 2018;  Published: 28 December 2018;  doi: 10.21926/obm.genet.1804058

Understanding the pathophysiology of disease can be an essential step to determining where and how to intervene for preventive or corrective health. Intrauterine growth restriction (IUGR) has been defined in livestock species as impaired gestational development of a fetus or its parts [1]. This broad category of ailments described by low fetal weight is accompanied by susceptibility to adult onset of chronic disease through fetal programming of numerous organ systems and their functions. This concern affects humans [...]

by J. Kim Penberthy  , Dinesh Chhabra  , Nina Avitabile  , J. Morgan Penberthy  , Ngan Le  , Yiqin Roger Xu  , Seara Mainor  , Natalie Schiavone  , Paul Katzenstein  , Janet E Lewis  and Leslie Hubbard

Received: 18 April 2018;  Published: 28 December 2018;  doi: 10.21926/obm.icm.1804039

Over the past few decades, there have been minimal advances in effective new behavioral or psychotherapeutic interventions for people living with autoimmune diseases such as systematic lupus erythematosus. This is problematic due to the severe, debilitating and potentially life-threatening nature of these diseases. Mindfulness based interventions, such as Mindfulness Based Stress Reduction, have demonstrated effectiveness in a wide range of patient populations and we hypothesize such treatment would also benefit pa [...]

by Joseph V. Pergolizzi  , Robert Taylor  , Robert B. Raffa  and Jo Anne LeQuang

Received: 27 July 2018;  Published: 28 December 2018;  doi: 10.21926/obm.icm.1804038

Background: The leaves of Mitragyna speciosa (kratom), a tropical tree that is indigenous to Southeast Asia, have been used traditionally to increase stamina, as a digestive aid, and as an analgesic. Kratom use is now increasingly popular in the rest of the world because of easy availability through the Internet and real, or perceived, views of efficacy and safety. Methods: PubMed and MedLine searches were conducted of published articles available in English. Results: Mitragynine and 7-hydroxymitragynine are the pr [...]

by Jeremy M. Quintana  , Alexandra L. Stinchcomb  , Jessica H. Kostyo  , Blair M. Robichaud  , Michael A. Plunk  and Robert R. Kane

Received: 08 October 2018;  Published: 28 December 2018;  doi: 10.21926/obm.transplant.1804036

Islet transplantation has proven to be a viable treatment for individuals suffering from both Type 1 Diabetes Mellitus (T1D) and chronic pancreatitis. However, a variety of challenges limit the effectiveness of this procedure by reducing the number of islets that survive the harvesting and transplantation processes. Increasing islet survival would increase the long-term effectiveness of the procedure and allow this technique to be used in more patients. A number of factors have been shown to improve the outcomes of [...]

by Whitney Rabacal  , Emily Rayens  and Karen Norris

Received: 02 November 2018;  Published: 27 December 2018;  doi: 10.21926/obm.genet.1804057

Pneumocystis causes life-threatening pneumonia in immunocompromised populations. More recently it has been implicated as a co-factor in a number of chronic lung diseases including chronic obstructive pulmonary disease (COPD), severe asthma, and cystic fibrosis (CF). In this review, we will examine the current literature regarding Pneumocystis and lung diseases in the HIV-infected patients and non-HIV immunocompromised populations, and the barriers to prophylaxis and treatment in these patients. Trimethoprim sulfame [...]

by HIrotaka Yamamoto  , Maiko Kisino  , Shunichi Nakamura  and Kastutoshi Tokushige

Received: 12 November 2018;  Published: 27 December 2018;  doi: 10.21926/obm.hg.1804012

Objective: Elastography is a non-invasive examination method that can estimate the extent of liver fibrosis, measured as liver stiffness (LS). We examined the relationship between gastro-esophageal varices and the LS and how to predict esophageal varices and varices bleeding by LS. Methods: From 2014 to 2016, we conducted a retrospective study of 138 subjects, all of whom were patients with chronic liver disease, including NAFLD, alcoholic liver disease, primary biliary cholangitis, viral hepatitis, and others. LS [...]

by Ashrit Multani  and Stanley Deresinski

Received: 31 October 2018;  Published: 27 December 2018;  doi: 10.21926/obm.transplant.1804035

Strongyloides stercoralis, an intestinal parasitic nematode (roundworm), infects more than 100 million people worldwide. While most infected immunocompetent persons are either asymptomatic or experience only mild, intermittent symptoms, immunosuppressed individuals, including those undergoing solid organ transplantation, are at increased risk for developing the frequently fatal hyperinfection syndrome. Donor-derived strongyloidiasis has recently become increasingly recognized and reported but current donor screenin [...]

by Feliciano Villar  , Montserrat Celdrán  , Rodrigo Serrat  and Valentina Cannella

Received: 07 November 2018;  Published: 26 December 2018;  doi: 10.21926/obm.geriatr.1804027

Active aging is a concept used to describe and promote lifestyles that contribute to a healthy aging process. However, these lifestyles vary widely, and the concept of active aging encompasses many activities. This paper considers two axes to classify the range of activities that can contribute to active aging: the resources needed to carry out such activities (low and high-resource needs) and the main orientation of the activities (self-oriented vs. activity with others). To illustrate this classification, three t [...]

by Atsushi Naganuma  , Satoru Kakizaki  , Takashi Hoshino  , Toshiyuki Tanaka  , Tetsushi Ogawa  , Shuya Sawada  , Satomi Adachi  , Yusuke Ogawa  , Toyoshi Sasaki  , Ken Sato  , Hitoshi Takagi  and Toshio Uraoka

Received: 25 September 2018;  Published: 26 December 2018;  doi: 10.21926/obm.hg.1804011

Background: Branched-chain amino acids (BCAA) are nutrients with a bitter taste, which causes low compliance in patients who need BCAA supplementation. Moreover, chronic liver disease is frequently complicated by taste impairment. The present study was designed to improve patient noncompliance regarding nutrients in liver disease. Methods: A taste questionnaire was administered to healthy controls, chronic hepatitis patients, and cirrhotic patients. Eleven different flavored powders that can be added to BCAA nutri [...]

by Robert Zheng

Received: 05 October 2018;  Published: 25 December 2018;  doi: 10.21926/obm.geriatr.1804026

The current article addresses the working memory constraints experienced by older people in caregiving training. Two different approaches aiming to free the older people’s working memory space were discussed. They include multi-modal visual processing and Gc activation. The emphasis was on the theoretical underpinnings of both approaches with empirical evidence from the research and literature to demonstrate their effectiveness in older people’s caregiving training. Further discussion was made with respect to the t [...]

by Craig A Talmage  and Richard C Knopf

Received: 30 October 2018;  Published: 24 December 2018;  doi: 10.21926/obm.geriatr.1804025

Background: Wisdom and curiosity require greater attention in the lifelong learning literature pertaining to older adulthood. Lifelong learning can assist older adults in amalgamating wisdom and pursuing their curiosities, but how wisdom is amalgamated and how curiosity is pursued in older adulthood needs more exploration. Methods: This qualitative study investigates subthemes of wisdom amalgamation and curiosity pursuits elucidated from interviews of older adults who participated in a university-based lifelong lea [...]