Serious Illness Management: A Fuller Approach to Integrative Palliative Care
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Table of Content
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Enhanced Long-term Antithrombogenicity Instigated by Covalently-Attached Surface Modifier on Biomedical PolymersAbstract
During a variety of medical procedures such as renal dialysis, bypass surgery, and lung transplantation patient blood is exposed to the surface of a number of polymeric materials such as polycarbonate (PC), poly (vinyl chloride) (PVC) and polysulfone (PS) for a period up to several days. Such exposure may result in undesirable protein-material interactions that can potentially trigger deleterious biological processes including thrombosis, which may be responsible for other complications such as cognitive disability [...] 2193 10504 |
Exploring Potential Neurobiological Parallels of Restrictive Behaviour: Anorexia Nervosa and Chew and Spit (CHSP)Abstract
Consensus for where along the eating disorder spectrum the pathological eating behaviour of Chew and Spit (CHSP) falls has been a point of contention in academic literature. Using the case of Mary1, a 30 year old female from Australia who has engaged in excessive restrictive behaviour, was diagnosed with anorexia nervosa (AN) and has been engaging in Chew and Spit (CHSP) behaviour for over 10 years, the current paper examines the similarities from a neurobiological perspective between restrictive behaviours (akin w [...] 2023 11810 |
The Use of ECMO in Treatment of Post Liver Transplant Septic ShockAbstract
Liver transplant is a life-saving therapy for patients with end stage liver disease and liver cancer. Liver re-transplantation cases are usually more challenging and riskier than primary surgery, they require careful consideration and larger recourse utilization. Decision making on who receives transplantation surgery includes individual patient risks and benefits, physician judgment, specific transplant center policies, surgical experience, geographic organ availability, and ethical considerations. Several mathema [...] 1908 12109 |
Breeding “CRISPR” Crops1Abstract
The challenges which face the world today can be summed up in a few words: An increasingly congested world with dwindling areas of viable cultivated land and accelerating climate instability. The combined effect of these realities, together with the trend of striving to extend the average human life, puts the world on the path toward future catastrophe. This situation makes it imperative to seek realistic and practical solutions, which must be able to address food shortages and climate problems in a timely manner. [...] 2065 9673 |
Testing the Correlation between Prior Knowledge of - and Visualisation Guided WTPs for Reducing the Visual Impacts Visual from Offshore Wind FarmsAbstract
Visual external costs are significant elements in the cost-benefit analysis of wind farm locations. This has been demonstrated well in the literature. However, in the assessment of the visual costs, a large share of the earlier studies used no or only simplistic visualizations of the visual impacts at stake. The cost estimates thus rely on the respondents’ ability to imagine the visual impacts associated with wind turbines of different sizes and at different locations. This has been argued to potentially reduce the [...] 1970 9168 |
Human Gut Microbiota: Friend or Foe?by
Monika Pliszka
and
Leszek Szablewski
Abstract
The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Similarly, human health depends on the composition of gut microbiome, with gut bacteria playing a crucial role in human physiology. For instance, gut microbiota synthesizes vitamins and amino acids, and affects the biotransfor [...] 1574 8677 |
Neurostimulation Approaches in the Treatment of Severe Anorexia Nervosaby
Amanda Baker
Abstract
Psychiatry is seeking interventions that could reliably sustain weight gain and psychosomatic recovery of patients with severe anorexia nervosa (AN). Currently, patients with AN, even after receiving individually-tailored therapeutic interventions, often relapse following marginal weight restoration. Also, the evidence regarding the effectiveness of psychotropic medications in relieving and treating AN symptomology is limited. The research in the field is aiming to mitigate shortcomings associated with common pract [...] 2031 13671 |
Preclinical Investigation of the Acute Effects of Trigonella foenum-graecum Seed Powder on Blood Glucose in Normal and Alloxan-Induced Diabetic RabbitsAbstract
To investigate the blood glucose lowering effect of the seed powder of T. foenum-graecum Linn (Papilionaceae) in normal and alloxan-induced diabetic rabbits. The blood glucose lowering effect of the seed powder was determined in normal and alloxan-induced (100 mg/kg, i.v.) diabetic rabbits, after oral administration of doses of 50, 100 and 150 mg/kg body weight. Blood samples were collected from the marginal ear vein before and also at 4, 6, 8, 10, 12, 16, 18, 20 and 24 h after drug administration and blood glucose [...] 2125 10472 |
Detection of Circulating Tumor DNA in Solid TumorsAbstract
Cancer is characterized by sequential and progressive genetic and epigenetic alterations in key proto-oncogenes and tumor suppressor genes, which ultimately lead to tumor development. Advances in the technology of analysis of molecular mechanisms have increased the efficiency of clinical management of cancer patients. Recent years have witnessed a progressive development in technologies that enable the detection of specific molecular abnormalities associated with various types of solid tumors in body fluids, a proc [...] 2066 11123 |
Grid Integration of a Residential PV-based Hybrid Renewable Energy System Using High-Frequency Multi-winding TransformerAbstract
In this paper, a topology of a residential hybrid renewable energy system based on a high-frequency multi-winding transformer is introduced and analyzed. The system includes a PV and a wind-turbine as renewable energy sources, a battery as energy storage and their energies are integrated through a high-frequency transformer. In fact, the transformer integrates the energies in a magnetic form and also isolates the system inputs and outputs. The integrated output from renewables and battery is a DC high-voltage and i [...] 2014 11118 |
Sustainability Implications of Using Hydrogen as an Automotive Fuel in Western AustraliaAbstract
Hydrogen is regarded as a potential solution to address future energy demands and environmental protection challenges. This study assesses the triple bottom line (TBL) sustainability performance of hydrogen as an automotive fuel for Western Australia (WA) using a life cycle approach. Hydrogen is considered to be produced through water electrolysis. Two scenarios, current grid electricity and future renewable-based hydrogen, were compared with gasoline as a base case. The results show that locally produced grid elec [...] 2141 11894 |
Seismic Imaging of Convective Geothermal Flow Systems to Increase Well ProductivityAbstract
A core feature of convective geothermal resource production is wellbore energy flow Q ~ ρC x T x V. E.g., for wellbore fluid of volume heat capacity ρC ~ 4.3MJ/m3.oC, temperature T ~ 230oC, and volumetric flow V ~ 50L/s, wellbore heat energy production is Q~ 50MWth ~ 5MWe. Wellbore fluid flow V =2πr0ϕv0ℓ for open wellbore length ℓ is given in turn by the spatially variable product crustal porosity times crustal fluid velocity v ≡ ϕv0 at the wellbore rad [...] 2125 13652 |
Establishing a Method for Quantifying Spinal Curvature during Videofluoroscopic Swallow Studies: Applying the Modified Cobb Angle to Healthy Young and Older AdultsAbstract
The Cobb angle is traditionally used for quantifying the degree of spinal curvature through evaluation of the full spinal cord. When conducting measurements on videofluoroscopy swallowing studies (VFSS), the Cobb angle can measure degree of cervical vertebrae curvature, which may have implications for swallowing. Given that this measure may have utility in dysphagia research, the reliability of this measure taken from C2-C4 and establishing the presence of changes with age were the focus of the current, proof-of-pr [...] 2109 11824 |
Neonatal Hypoxic Ischemic Encephalopathy: An Updated Preclinical and Clinical ReviewAbstract
Hypoxic-ischemic encephalopathy is a major cause of death and disability in the newborn period. Experimental models have demonstrated that brain injury in hypoxic-ischemic encephalopathy occurs in two phases: primary energy failure and secondary energy failure. In primary energy failure, there is a cessation of oxidative metabolism and irreversible neuronal injury, followed by secondary energy failure due to glutamate release, elevation of intracellular calcium, reactive oxygen species formation, apoptotic cell dea [...] 2536 27617 |
Cognitive Impairment, Meditative Movement, and Gene Expression in Breast Cancer Survivorsby
Francisco V. Muñoz
and
Linda Larkey
Abstract
Breast cancer survivors (BCSs) report decrements in cognitive functioning. A Meditative Movement (MM) program (Qigong/Tai Chi Easy) combines meditation and exercise, practices known to improve cognitive function. Method: Using a single group, pre- to post-intervention assessment design, a pilot study was conducted in BCSs to test the effects of an 8-week MM intervention on cognitive functioning, sleep and mood and to explore changes on selected gene expression factors, BDNF, NF-kB1, and TP53, expected to improve wi [...] 1875 12244 |
A Simplified Optimization Model for Sizing Proton-Exchange Membrane Fuel CellsAbstract
The fluctuations in the cost of energy coupled with the gradual decrease in natural resources (i.e., oil, natural gas, coal) and the environmental issues caused by the extensive use of fossil fuels, demand the urgent need for the development of advanced and clean energy systems. The European Union has requested new measures to target climate and energy deterioration by developing renewable energy sources by 2030. The stochastic character of the energy sources and the fluctuation in demand for the energy systems pos [...] 2108 11457 |
Behavioral Disorders and Celiac Disease: Coincidence or Casualty?Abstract
This paper presents the case of a child diagnosed with both celiac disease and Asperger’s syndrome. The literature does not report this association to date, and the authors believe it to be a coincidence rather than a casualty. 1825 12875 |
A Preparation and Structural Characterization of the Hydrated Trifluoride Salt of the [Co(NH3)6]3+ Cation: [Co(NH3)6]F3 · 2H2O. The Unexpected Preparation of [Co(NH3)6](BF4)(SiF6) from Pyrex Glass, and the Syntheses and Structures of (NH4)[Co(NH3)6](BF4)2(2Cl) and of (NH4)[Co(NH3)6]2(SiF6)3(Cl) · 3H2OAbstract
It is historically interesting to note that, whereas the [Co(NH3)6]3+ cation was isolated by Tassaert in 1798 (which he described as the tri-chloride) and that, in the early days of Coordination Chemistry, Jørgensen and Werner isolated many of its other salts, the fluoride was never reported. In fact, in relatively modern times, lack of success was, invariably, the result of attempting its isolation and full characterization. Significantly, there is no entry for its structure in standard sources such as Inorganic C [...] 1419 9058 |
Using Acoustic Fields to Fabricate ECM-Based Biomaterials for Regenerative Medicine ApplicationsAbstract
Ultrasound is emerging as a promising tool for both characterizing and fabricating engineered biomaterials. Ultrasound-based technologies offer a diverse toolbox with outstanding capacity for optimization and customization within a variety of therapeutic contexts, including improved extracellular matrix-based materials for regenerative medicine applications. Non-invasive ultrasound fabrication tools include the use of thermal and mechanical effects of acoustic waves to modify the structure and function of extracell [...] 2440 14676 |
Use of Organs from Hepatitis C Viremic Donors: Addressing the Needs of a Changing Waitlist and the Effect of a Public Health CrisisAbstract
The combination of broad screening initiatives and development of effective antiviral therapies have led to a revolution in the treatment of hepatitis C virus and has reduced the proportion of patients with the virus who develop a need for liver transplantation in favor of other etiologies, such as alcohol-related liver disease and non-alcoholic steatohepatitis. However, the opioid epidemic and rise in injection drug use in the United States has simultaneously led to otherwise healthy hepatitis C viremic patients d [...] 1498 6782 |
Child Life Specialists in Pediatric Hospital Careby
Kokila Jeyamurugan
and
Ratna B Basak
Abstract
Child life specialists (CLS) are trained providers who form part of a pediatric multidisciplinary and pediatric palliative care team. Their role is invaluable to mitigate the stress and anxiety of children during hospitalization. They may use various strategies in children like play, art and music therapy and pet therapy, to help self-express and cope with painful procedures.
We present a brief narrative on CLS with a case of a 10- year- old Hispanic boy who had metastatic osteosarcoma.
The case illustration is f [...] 2476 12684 |
Neurological Manifestations of the Celiac Disease in ChildrenAbstract
Gluten-related disorders (GRDs) represent a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. The most common and widely recognized diseases within this spectrum are celiac disease and non-celiac gluten sensitivity. The clinical manifestations are intestinal, but extraintestinal manifestations may also appear, such as neurological or psychiatric.
This work will specifically review the neurological or psychiatric manifestations that are more freq [...] 2012 17475 |