by Arbnora Batalli-Kepuska  , Lidvana Spahiu  , Emir Behluli  and Gazmend Temaj

Received: 08 February 2024;  Published: 19 July 2024;  doi: 10.21926/obm.genet.2403253

Several therapeutic methods are used to cure acute lymphoblastic leukemia (ALL). Relapsed/refractory B-cell ALL (R/R B-ALL) remains the primary cause of death worldwide due to the limitation of cure. Blinatumomab is a bispecific T-cell engaging antibody used to treat R/R B-ALL. The use of blinatumomab for treating R/R B-ALL has shown to be very efficient, especially as a bridge tool to hematopoietic stem cell transplantation (HSCT). The response to blinatumomab treatment ranged from 69% after two cycles in phase II [...]

by Mª Carmen Márquez

Received: 27 March 2024;  Published: 18 July 2024;  doi: 10.21926/cr.2403009

Lipase-catalyzed hydrolysis of olive oil has been studied in the absence of emulsifier. A simple mathematical model to predict the hydrolysis rate is derived from a proposed kinetic mechanism of the reaction. The hydrolytic reaction obeys Michaelis-Menten kinetics with a simultaneous second-order enzyme deactivation. The model predictions closely agree with the experimental results.

by Maria Lúcia dos Santos  , Ana Cristina Monteiro  , Andréa Nascimento  , Sívia Barbosa  , Artur Delgado  and Patrícia Zamberlan

Received: 11 April 2024;  Published: 17 July 2024;  doi: 10.21926/rpn.2403010

Epidermolysis Bullosa (EB) is a rare genetic disorder characterized by fragile skin that blisters and tears easily, leading to significant morbidity and mortality. Depending on the specific genetic mutations and the proteins involved, EB can be classified into several subtypes whose molecular complexity is compounded by the variability in mutation types (missense, nonsense, insertions, deletions), their locations within the genes, and the resultant effects on protein function. This systematic review aimed to identi [...]

by Assohoun Fulgence Kraidy  , Islam M. El Radaf  , Andreas Zeinert  , Abdelilah Lahmar  , Aime Pelaiz-Barranco  , Pardis Simon  and Yaovi Gagou

Received: 29 March 2024;  Published: 17 July 2024;  doi: 10.21926/jept.2403013

In this study, tin antimony sulfide (SnSb2S5) thin films with 200 nm, 312 nm, and 431 nm thicknesses were successfully fabricated using thermal evaporation. These films' structural, optical, and photoanode properties were meticulously characterized to assess their suitability for photovoltaic applications. X-ray diffraction (XRD) analysis confirmed the presence of an orthorhombic symmetry phase within the Pnma space group, ensuring the crystalline quality of the films. Raman spectroscopy further validated the cryst [...]

by Mélanie Couture  , Julien Gauthier-Mongeon  , Pearce Simamonika  , Rosalie Bernard  , Kevin St-Martin  , Rosalie Lacasse  and Sarita Israel

Received: 18 December 2023;  Published: 17 July 2024;  doi: 10.21926/obm.geriatr.2403282

Research indicates that adults in the context of gender and sexual diversity (GSD) experienced more violence and discrimination than the rest of the population. GSD refers to all the diversities of sexual characteristics, sexual orientations and gender identity of a person or a group. To encourage the use of evidence-based interventions in health and social services, it is important to extrapolate from the scientific literature how mistreatment situations are managed in this context. A scoping review was conducted [...]

by Havva Özgen Eyüpoğlu  , Erol Eyüpoğlu  and Nedime Serakinci

Received: 13 March 2024;  Published: 17 July 2024;  doi: 10.21926/obm.genet.2403252

Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication dis [...]

by Roberto Anaya-Prado  , Ana P. Cárdenas-Fregoso  , Ana M. Reyes-Perez  , Danielle M. Ortiz-Hernandez  , Montserrat Quijano-Ortiz  , Monica V. Delgado-Martinez  , Ana S. Pelayo-Romo  , Roberto Anaya-Fernández  , Michelle M. Anaya-Fernández  , Consuelo C. Azcona-Ramirez  , Ivan F. Garcia-Ramirez  , Miguel A. Guerrero-Palomera  , Daniel Gonzalez-Martinez  , Citlalli S. Guerrero-Palomera  , Karina Paredes-Paredes  and Claudia Garcia-Perez

Received: 23 February 2024;  Published: 16 July 2024;  doi: 10.21926/obm.neurobiol.2403232

The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and b [...]

by Ioannis Syros  and Xenia Anastassiou-Hadjicharalambous

Received: 19 October 2023;  Published: 15 July 2024;  doi: 10.21926/obm.neurobiol.2403231

Obsessive-Compulsive Disorder (OCD) is a prevalent child and adolescent psychiatric condition characterized by substantial functional impairments. Cognitive Behavioral Therapy (CBT) has emerged as the primary therapeutic approach for managing mild to moderate cases of OCD in children and adolescents. Significant advancements have been made in applying CBT specifically to this age group in the past decade. Exposure and response prevention (ERP) is a core therapeutic technique grounded in the principle that anxiety t [...]

by Eli Cwinn  and Kayla Hamel

Received: 22 January 2024;  Published: 10 July 2024;  doi: 10.21926/obm.icm.2403041

This paper argues that psychology, as a discipline, requires research to be situated in the context of a content-based theory. We identify several problems and pitfalls with requiring a content-based theory for applied mental health research, a priori. Nonetheless, we also articulate a rationale for why theory matters and that a new sort of theoretical framework is required for applied mental health research. We address this need by articulating a new theoretical framework called Applied Pragmatic Functional Contex [...]

by Koré Monsterrat Moreno-Calderón  , Alfredo Saavedra-Molina  , Mariana Gómez-Barroso  , Donovan Javier Peña-Montes  , Christian Cortés-Rojo  , Alain R. Rodríguez-Orozco  , Omar Ortiz-Ayala  and Rocío Montoya-Pérez

Received: 08 January 2024;  Published: 10 July 2024;  doi: 10.21926/obm.icm.2403040

An excess of adipose tissue characterizes obesity; it is associated with complications such as diabetes and cardiovascular diseases due to an alteration in the lipid profile; this condition affects all tissues; even skeletal muscle is the most affected, causing its malfunction and bringing more significant consequences. Exercise has been described as one of the best treatments to combat obesity. At the same time, E. carlinae is a plant proven to have lipid-lowering and hypoglycemic effects, improving the function o [...]

by Giuseppe Merra

Received: 03 July 2024;  Published: 10 July 2024;  doi: 10.21926/obm.genet.2403251

by Anna Passaro  , Antonio Zullo  , Mariacarla Di Gioia  , Enza Curcio  and Fabrizio Stasolla

Received: 27 January 2024;  Published: 05 July 2024;  doi: 10.21926/obm.genet.2403250

Rett syndrome (RTT) is a rare neurodevelopmental disorder primarily affecting females, characterized by a spectrum of debilitating symptoms that impact neurological, cognitive, and motor functions. Eye-tracking technology (ETT) has emerged as a prominent tool in Augmentative and Alternative Communication (AAC) systems, particularly for neurological patients with motor and verbal impairments. This narrative review aimed to evaluate studies conducted on the use of ETT to improve cognitive abilities in girls with RTT [...]

by María del Valle del Olmo de Dios  , Alfonso Roberto Barros-Loscertales  and Laura Laguna Cruañes

Received: 25 September 2023;  Published: 05 July 2024;  doi: 10.21926/obm.icm.2403039

Mediterranean diet, considered key to varied diets, raises whether it is necessary to supplement it with compounds like nutraceuticals to obtain more benefits. A scoping review was conducted. Nine articles were selected that compared the effects of nutraceuticals on biochemical markers (such as total cholesterol (TC), low-density lipoprotein cholesterol (LDLc)), weight, and blood pressure in various studies to the results observed in groups only exposed to the Mediterranean diet. The aim was to assess the impact of [...]

by Oyovwi Mega Obukohwo  , Peggy Ejiro Ohwin  , Rotu Arientare Rume  , Olowe Gideon Temitope  , Oyelere Abosede Oreoluwa  and Adelowo Joy Motunrayo

Received: 19 February 2024;  Published: 05 July 2024;  doi: 10.21926/obm.genet.2403249

Chromosome abnormalities are a leading cause of pregnancy loss, developmental delays, and birth defects. These abnormalities arise from errors in chromosome structure (breakage) or number (missegregation) during cell division. Understanding the causes of these errors is crucial for developing effective preventive strategies to improve reproductive health. This paper aims to review the known causes of chromosome breakage and mis-segregation, emphasizing their impact on pregnancy and newborn health. It further explor [...]

by Sara Alattar  , Muhammad Nouman  , Chidozie Onyiuke  , Conrad Stasieluk  and Edwin Meresh

Received: 29 November 2023;  Published: 05 July 2024;  doi: 10.21926/obm.neurobiol.2403230

Studies have shown that decrease in time intubated is associated with better prognosis. Delirium is associated with increased duration of mechanical ventilation and Intensive Care Unit (ICU) length of stay. However, there is limited report on delirium in intubated seizure patients. As per report, low Glasgow Coma Scale (GCS) increased the risk of delirium and thus increasing ICU length of stay. Information on delirium and outcome in intubated seizure patients receiving lacosamide versus phenytoin is limited. Our re [...]

by Leila Naseri  , Mohsen Akbaribazm  and Mozafar Khazaei

Received: 06 February 2024;  Published: 04 July 2024;  doi: 10.21926/obm.genet.2403248

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy causing non-ovulation infertility in women. Women with PCOS have higher levels of luteinizing hormone (LH), testosterone, cholesterol and triglycerides but, in contrast, lower levels of follicular stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) compared with healthy counterparts. Because of the limitations of human studies, animal models of PCOS have been developed to identify appropriate therapeutics and to explore their mechanism [...]

by Sergey Evstropiev  , Andrey Shelemanov  , Igor Bagrov  , Anna Karavaeva  , Kseniya Portnova  and Nikolay Nikonorov

Received: 06 April 2024;  Published: 03 July 2024;  doi: 10.21926/cr.2403008

Disperse porous Mn-doped ZnO-ZrO2 nanocomposites were prepared using the facile polymer-salt method. The effect of Mn content on the crystal structure, composite morphologies, their ability to photogenate the singlet oxygen, luminescence properties, and bactericidal activities were studied. The crystal structure and morphology of these materials were investigated using XRD and SEM analysis. It was found that obtained nanocomposites consist of small (~9 nm) hexagonal ZnO and fine ZrO2 crystals and the embedding of M [...]

by Van Anh Vu  , Joelle Nelson  , Helen Sweiss  , Reed Hall  , Holly Keyt  and Elisabeth Kincaide

Received: 29 January 2024;  Published: 03 July 2024;  doi: 10.21926/obm.transplant.2403220

Secondary hypogammaglobulinemia (HGG) from immunosuppression therapy in lung transplant recipients has been associated with increased mortality, morbidity and higher risk of infection. Intravenous immunoglobulin (IVIG) for the treatment of HGG post-lung transplant is not well studied with conflicting evidence regarding efficacy. This single-center, retrospective cohort study analyzed adult lung transplant recipients with HGG receiving ≥1 dose of IVIG 0.3-0.5 g/kg. Resolution of HGG (IgG > 600 mg/dL wi [...]

by Roghieh Nooripour  , Maryam Ghanbari Viki  , Nikzad Ghanbari  , Fardin Farmani  and Farinaz Emadi

Received: 07 April 2024;  Published: 01 July 2024;  doi: 10.21926/obm.neurobiol.2403229

Learning disabilities (LDs) encompass a range of cognitive challenges that can significantly influence students' educational experiences and overall academic performance. This study aimed to investigate the effects of alpha/theta neurofeedback rehabilitation on attention and working memory in female students with learning disabilities. This study employed a quasi-experimental design with pre-tests, post-tests, and a two-month follow-up and included a control group. Convenience sampling was used to select 40 fem [...]

by Regina M. Mackey  , Macaila Eick  , Sara Jacobsen  , Abraham Labrada Satiago  and Maria I. Lapid

Received: 26 February 2024;  Published: 01 July 2024;  doi: 10.21926/obm.geriatr.2403281

How should Palliative Medicine competencies be taught to medical students? In the United States and other countries, there is a consensus that teaching Palliative Medicine competencies to medical students is essential. Health agencies have also identified teaching Palliative Medicine competencies as crucial. According to Sanchez-Reilly and Ross, medical students reported that they feel better prepared to care for the elderly, patients with severe illness, and dying patients after completing formal training. The aut [...]

by Luana Góes Soares  , Sandra Kunst  , Cláudia Trindade Oliveira  and Annelise Kopp Alves

Received: 04 February 2024;  Published: 01 July 2024;  doi: 10.21926/cr.2403007

Sustainability has driven the use of heterogeneous photocatalysis as one of the primary methods for environmental decontamination, reduction, degradation, remediation, or transformation of polluting chemical residues and purification treatment of effluents and wastewater. TiO2 is the most commonly used semiconductor in heterogeneous photocatalysis. It acquires relevance, as it has favorable properties, such as non-toxicity, stability in a wide range of pH, economic viability, etc., which encourage its application a [...]

by Amos O. Oyatogun  , Emmanuel Ajenifuja  , Abimbola P. Popoola  , Olawale Popoola  , Fatai O. Aramide  and Grace M. Oyatogun

Received: 28 December 2023;  Published: 01 July 2024;  doi: 10.21926/rpm.2403016

High strength and good conductivity are both critical parameters for copper-based alloys for electrical and other technological applications. This study is aimed to produce copper alloys and metal matrix composites (MMCs) with enhanced physical properties. Cu-Ti-Ni ternary alloys and MMCs samples were sintered at 600 to 700°C using spark plasma sintering (SPS), with a heating rate of 100°C/minutes, uniaxial pressure of 50 MPa, and a holding time of 10 minutes. Scanning electron microscopy (FE-SEM) was used to exami [...]

by Sami Goren

Received: 02 January 2024;  Published: 01 July 2024;  doi: 10.21926/aeer.2403016

Waste production is experiencing a significant increase in correlation with the growth of the human population and industrial activities. The kind of waste that is expanding at a rapid rate is known as "e-waste," which stands for electronic waste. In the context of electronic waste, the term refers to the waste produced during the disposal of electronic devices and any other components utilized in making or operating these devices. In the same way that different types of waste occur, electronic waste pollutes the e [...]

by Oghenerume Lucky Emakpor  , Great Iruoghene Edo  , Emad Yousif  , Princess Oghenekeno Samuel  , Agatha Ngukuran Jikah  , Khalid Zainulabdeen  , Athraa Abdulameer Mohammed  , Winifred Ndudi  , Susan Chinedu Nwachukwu  , Ufuoma Ugbune  , Joy Johnson Agbo  , Irene Ebosereme Ainyanbhor  , Huzaifa Umar  , Helen Avuokerie Ekokotu  , Ephraim Evi Alex Oghroro  , Patrick Othuke Akpoghelie  , Joseph Oghenewogaga Owheruo  , Lauretta Dohwodakpo Ekpekpo  , Priscillia Nkem Onyibe  , Ufuoma Augustina Igbukuc  , Endurance Fegor Isojec  and Arthur Efeoghene Athan Essaghahk

Received: 28 December 2023;  Published: 28 June 2024;  doi: 10.21926/obm.icm.2402038

The optimal enhancement of athletic performance, recovery from exhaustion after exercise, and injury prevention are products of appropriate nutrition. Nutritional supplements that contain proteins, carbohydrates, vitamins, and minerals are frequently utilized in various sports to complement the recommended daily amounts. Several of these supplements have been identified to have physiological effects and, thus, are known to help enhance athletic performance and prevent injuries. Our review intends to show the interp [...]

by Josie M Rudolphi  , Courtney Cuthbertson  , Kimberly Keller  and Rebecca Mott

Received: 26 April 2024;  Published: 28 June 2024;  doi: 10.21926/obm.icm.2402037

Agricultural producers (i.e., farmers, ranchers) and agricultural workers (i.e., hired labor, farmworkers) have worse mental health than the general population and often lack access to mental healthcare. In response, the United States Department of Agriculture’s National Institute of Food and Agriculture funded four regional Farm and Ranch Stress Assistance Networks in 2019. In the north central region, the North Central Farm and Ranch Stress Assistance Center (NCFRSAC) was created in 2020 to develop, deliver [...]