by Jiani Yin  , David Oleson  and Christian P. Schaaf

Received: 31 August 2017;  Published: 24 February 2018;  doi: 10.21926/obm.genet.1801014

Autism spectrum disorder is a clinically heterogeneous condition, characterized by social deficits, language impairment, repetitive behaviors, and restricted interest. Autism displays significant genetic heterogeneity. In the past one and a half decades, next generation sequencing has enabled identification of many variants that predispose to autism. These discoveries have improved understanding of the disease etiology of autism spectrum disorder. In this review article, we will address how development of next gene [...]

by Udaya Kahangamage  , Yi Chen  , Chun Wah Leung  and Tung Yan Ngai

Received: 02 January 2022;  Published: 18 April 2022;  doi: 10.21926/jept.2202016

The lean-burning limits of hydrogen-enriched Liquefied Petroleum Gas (LPG) have been studied using a Bunsen burner. The lean-burning limits under different conditions are important design considerations in developing gas-fired domestic appliances. In this study, the lean-burning limits of hydrogen-enriched LPG have been obtained across a wide range of Reynolds numbers (600 to 1800) and H2 volumetric fractions (0% to 25%). The results show that the lean-burning limit is increased, on average, by 4.0% to 7.2% for eve [...]

by Eli Cwinn  , Tobyn Bell  and James Kirby

Received: 20 August 2023;  Published: 29 November 2023;  doi: 10.21926/obm.icm.2304056

This paper reviews key theories underlying the interpersonal process in Compassion Focused Therapy (CFT) and links these to purported mechanisms of action in CFT. The paper goes on to provide a concrete practice example of an exampled dialogue between a clinician and client and narrates the interpersonal processes and mechanisms of action in an attempt to elucidate how interpersonal processes can be leveraged to facilitate therapeutic change. In so doing, this paper seeks to advance scholarship on precise mechanism [...]

by Garuth Eliot Chalfont  , Jane Simpson  , Fiona J R Eccles  and Christine Milligan

Received: 06 September 2019;  Published: 21 January 2020;  doi: 10.21926/obm.geriatr.2001102

The urgent need for innovative approaches to dementia treatment that are acceptable, effective and affordable underlies this research. Growing evidence supports ‘integrative medicine’ as a potential treatment approach aligned with and including conventional medicine. However, success will depend on addressing barriers, recognising needs of diverse communities and involving people in co-creating desired interventions. The three aims of this study were to, 1) describe conventional allopathic medicine and integrative [...]

by Brian R. Stanmore

Received: 01 March 2021;  Published: 07 June 2021;  doi: 10.21926/aeer.2102013

A set of empirical models which accounts for the formation of gas phase polychlorinated dibenzo-p-dioxins and furans (PCDD and PCDF), and solid phase PCDD/F by the de novo mechanism is described.In each case, competing formation and destruction reactions are considered to operate.The effect of the time-temperature history on their formation is then examined.At high temperatures, steady-state is reached in fractions of a second, resulting in the observed low product concentrations.Rapid cooling as found in furnaces [...]

by Melissa A. Maloney  , Katherine E. Lewinter  , Sally L. Davidson Ward  and Iris A. Perez

Received: 13 November 2018;  Published: 16 December 2018;  doi: 10.21926/obm.neurobiol.1804017

Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hypothalamus and surrounding regions are prone to excessive daytime sleepiness. Sleep-related breathing disorders, especially those involving abnormal control of breathing, may occur in patients with tumors of the brainste [...]

by Terence Seedsman

Received: 01 August 2021;  Published: 15 March 2022;  doi: 10.21926/obm.geriatr.2201195

While increases in life expectancy along with extended longevity can be seen as a success story, there remains the central issue surrounding the health and quality of life for increasing numbers of older people. As populations live longer the idea that older people should be empowered to remain active and productive citizens will be paramount. Questions concerning the meaningfulness, purpose and desirability of living longer present an existential challenge for all and sundry. It is clear, that the speed of populat [...]

by Naiwei Chi  , Shuyao Zheng  , Elwin Clutter  and Rong Wang

Received: 30 October 2019;  Published: 18 December 2019;  doi: 10.21926/rpm.1904007

Background:Diabetic patients suffer from chronic wounds partly due to altered function of fibroblasts. Fibroblasts of diabetic patients synthesize collagen I (COLI) at a much higher level than collagen III (COLIII), resulting in delayed tissue granulation and, consequently, a delay in the overall wound healing process. Methods:We aimed to revive the matrix protein productivity of diabetic fibroblasts by employing aligned, electrically conductive and biocompatible spider silk-CNT fibers as a cell culture matrix to m [...]

by Antusia dos Santos Barbosa  and Meiry Gláucia Freire Rodrigues

Received: 24 October 2023;  Published: 28 January 2024;  doi: 10.21926/cr.2401002

The research describes a sustainable approach for the synthesis of zeolite NaA using kaolin as an alternative source of silica. The main objective of this research was to prepare NaA zeolite using metakaolin derived from kaolin from the state of Rio Grande do Norte, Brazil, as an alternative source of silica, reducing the production cost and evaluating its thermal stability. In addition, a study of the thermal stability of the zeolite and cost estimates for zeolite production were carried out. Traditional methods o [...]

by Yaser Banadaki  , Nariman Razaviarab  , Hadi Fekrmandi  , Guoqiang Li  , Patrick Mensah  , Shuju Bai  and Safura Sharifi

Received: 24 November 2021;  Published: 28 February 2022;  doi: 10.21926/rpm.2201005

Additive Manufacturing (AM) is a crucial component of the smart manufacturing industry. In this paper, we propose an automated quality grading system for the fused deposition modeling (FDM) process as one of the major AM processes using a developed real-time deep convolutional neural network (CNN) model. The CNN model is trained offline using the images of the internal and surface defects in the layer-by-layer deposition of materials and tested online by studying the performance of detecting and grading the failure [...]