by Serena A. Schade  , Julia O’Hanlon  and Elizabeth Orsega-Smith

Received: 09 June 2025;  Published: 12 September 2025;  doi: 10.21926/obm.geriatr.2503326

Senior centers serve as community anchors for the approximately 57.8 million older adults in the U.S., offering a range of health promotion programs, including exercise classes. This study examined how the type of exercise programs at senior centers influences older adults’ health (mental, physical, and quality of life) and how baseline physical activity levels may influence these changes as part of a statewide health promotion program evaluation in senior centers in Delaware. The exercise programs offered were bas [...]

by Corrado Angelini

Received: 06 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.icm.2402035

An 83-year-old man with myasthenia gravis was hospitalized in the ICU; support for caregivers of elderly myasthenic patients in the ICU can be a crucial aspect of their care. Myasthenia gravis is a chronic autoimmune neuromuscular disease that can cause varying levels of muscle weakness, which can significantly impact the patient's day-to-day activities and overall quality of life. This intervention was followed for over one month with success. The critical phases are presented and analyzed as a medical support art [...]

by Filomena Emanuela Laddaga  , Bruna Daraia  , Pamela Pinto  , Antonio D’amato  , Stella D’oronzo  , Stefano Martinotti  and Francesco Gaudio

Received: 23 January 2025;  Published: 06 June 2025;  doi: 10.21926/obm.transplant.2502250

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection, modification, and expansion, off-the-shelf therapies can be prepared in advance, substantially reducing treatment timelines, decreasing costs, and improving global acces [...]

by Ziyad Alharbi

Received: 27 March 2024;  Published: 13 January 2025;  doi: 10.21926/obm.transplant.2501231

The supraclavicular artery flap presents a promising solution for facial reconstruction challenges since 1997, surpassing limitations of traditional methods like the deltopectoral flap. Its extended pedicle and thin, pliable epidermis offer reliable outcomes with minimal donor site morbidity, making it a preferred choice for head and neck reconstruction. This systematic review evaluates the efficacy of pre-expanded supraclavicular artery flaps based on a comprehensive analysis. In accordance with the Preferred Repo [...]

by Alicia Morales  , Vania Cataldo  , Diego Berrios  , Ana Beatriz  , Karen Danke  , Gisela Jara  , Fabiola Werlinger  , Mauricio Baeza  , Viviana García Ubillo  and Jorge Gamonal

Received: 03 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.geriatr.2502316

It has been suggested that an individual's overall functional capacity gradually declines with age. It has been reported that a decline in oral functionality increases the risk of sarcopenia and frailty, which contributes to the decrease in functional capacity. In Chile, the Preventive Medical Examination for Older Adults (EMPAM) is used to assess the functionality of that population; however, this examination does not include an evaluation of oral functionality. To address this gap, the Preventive Dental Examinati [...]

by Gerhard Litscher

Received: 10 November 2025;  Published: 10 November 2025;  doi: 10.21926/obm.icm.2504049

During this year’s World Congress on Medical Acupuncture, the ICMART (International Council of Medical Acupuncture and Related Techniques) Science Award 2025 was presented in recognition of excellence in research and innovation within the field of medical acupuncture. The award honored pioneering work on acupuncture and moxibustion in chronic fatigue syndrome (CFS), conducted in collaboration with the team at Hubei University of Chinese Medicine, Wuhan. The study, a randomized controlled trial (RCT), showed that ac [...]

by Angelina Lamberti  , Sinan Haddad  , Stefan Wagenpfeil  , Thomas Vogt  and Jörg Reichrath

Received: 13 September 2024;  Published: 29 October 2025;  doi: 10.21926/rpn.2504024

Recommendations for vitamin D supplementation are essential for the prevention and therapy of vitamin D deficiency. However, reliable data remain lacking for children, as most intake recommendations are based on individual studies. This work aimed to obtain reliable data that allow health authorities to re-evaluate recommendations for oral vitamin D uptake in children. We conducted a systematic literature search in MEDLINE/PubMed on vitamin D supplementation in children. All randomized controlled trials (RCTs) publ [...]

by Waqar Husain

Received: 30 May 2025;  Published: 10 September 2025;  doi: 10.21926/obm.icm.2503037

Honor and shame function as moral currencies in many collectivistic cultures, shaping individual behavior, gender roles, and psychosocial well-being. This paper introduces Atimiaphobia—a newly proposed specific phobia defined as the intense and persistent fear of losing honor (particularly for men) or being labeled as shameless (particularly for women). Rooted in patriarchal, collectivist, and honor-based cultures, atimiaphobia manifests through intrusive thoughts, hypervigilance, emotional turmoil, and compu [...]

by John Salmon  and Peter D. Drummond

Received: 24 November 2024;  Published: 05 March 2025;  doi: 10.21926/obm.neurobiol.2501274

The aim of this study was to identify methodological issues that might influence comparison of burst versus sham spinal cord stimulation for treating chronic pain. Six patients with an implanted BurstDR spinal cord stimulator were assessed double-blind during eight 3-to-4-day ON or OFF cycles over a 28-day period. The stimulator was switched off during two randomly selected cycles. Pain intensity was the primary outcome, and secondary outcomes included analgesic consumption, activity estimation and sleep quality. T [...]

by Masahiro Sato  , Emi Inada  , Satoshi Watanabe  , Issei Saitoh  , Naoko Kubota  , Yoko Iwase  , Kazunori Morohoshi  and Shingo Nakamura

Received: 31 August 2025;  Published: 24 November 2025;  doi: 10.21926/obm.genet.2504317

An episomal vector is a plasmid- or virus-based vector that is present extrachromosomally in cells after transfection. Although it disappears during cell proliferation, it can exist in non-dividing cells, such as neuronal and muscular cells, and continues to express a gene of interest (GOI). Such episomal vectors are usually based on sequences from DNA viruses such as bovine papillomavirus 1 and Epstein-Barr virus. When cells are transfected with an episomal vector harboring a drug-resistance gene and subsequently [...]