Table of Content

Open Access Original Research

The Contribution of Dietary Fatty Acids to Prediction of All-Cause Mortality in a Cohort of Middle-Aged Men Followed-Up for 61 Years Until Extinction

Received: 09 November 2024;  Published: 19 May 2025;  doi: 10.21926/rpn.2502011

Abstract

To describe the contribution of three classes of dietary fatty acids to all-cause mortality and age at death among middle-aged men followed up for 61 years until extinction. The cohort comprised 1712 men aged 40-59 years at entry examination in 1960, belonging to the Italian Rural Areas of the Seven Countries Study of Cardiovascular Diseases. A dietary survey allowed to estimate dietary fatty acids [saturated (SAFA), mono-unsaturated (MUFA), poly-unsaturated (PUFA) and their ratios (M/S, P/S)] that were fed as poss [...]

1101 4385

Open Access Editorial

Acknowledgement to Reviewers of OBM Neurobiology in 2023

Received: 03 January 2024;  Published: 02 January 2024;  doi: 10.21926/obm.neurobiol.2401204

Abstract

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the [...]

989 4377

Open Access Original Research

An Exploration of the Experiences of Group Compassion Focused Therapy for Hospital Outpatients with Long-Term Mental Health Difficulties

Received: 07 April 2025;  Published: 12 January 2026;  doi: 10.21926/obm.icm.2601005

Abstract

There is now good evidence for the efficacy of Compassion Focused Therapy (CFT) for a variety of mental health difficulties. To deepen understanding of the processes underpinning CFT’s effectiveness, this service evaluation explored the experiences and reflections of individuals with long-term mental health difficulties who had previously received therapy and attended an 11-week CFT group. Ten clients were invited to the group; one withdrew before the group started because of work and personal commitments and anoth [...]

2387 4332

Open Access Original Research

“At My Age, Its Perhaps the End of My Walking or the End of a Lot of My Life”: A Phenomenological Study of the Lived Experiences of a Serious Fall to Independent Older Adults

Received: 04 February 2025;  Published: 01 August 2025;  doi: 10.21926/obm.geriatr.2503319

Abstract

The purpose of this original research was to describe the lived experience and meaning of a serious fall to independently residing older adults. A qualitative phenomenological approach was utilized with a purposive sample of 19, independent, high-level functioning older adult residents of a Continuing Care Retirement Community to describe their most serious fall and its personal meaning. Traced through multiple data sources, interpretive analysis of the language expressed by older adults were integrated to support [...]

955 4320

Open Access Research Article

Modeling the Mesoscopic-Scale Spatial Evolution of the Epileptic Pre-Ictal and Ictal Phases

Received: 13 December 2024;  Published: 23 June 2025;  doi: 10.21926/rpse.2502011

Abstract

The spatial evolution of the epileptiform regime in neural networks can be alternatively described in terms of a statistical approach, dealing with average smooth, differentiable fields rather than discrete neural elements. After a brief review of mathematical methods for modeling epilepsy (the condensed matter vs. the neural mass models) together with their pros and cons, we introduce our continuous-space model for the pre-ictal scalar field and the ictal epileptiform vector flux in the form of the diffusion equat [...]

1068 4311

Open Access Research Article

External Validation and Modification of a New Score for Predicting Mortality in Patients with COVID-19 in High Altitude Patients. A Peruvian Study

Received: 07 December 2022;  Published: 20 November 2024;  doi: 10.21926/obm.genet.2404271

Abstract

This study aims to validate two predictive mortality scores for patients with COVID-19 to support clinical decision-making in those who require hospitalization. The tomographic patterns found can be added to the original scores to increase their predictive power. Retrospective, analytical, observational, and cross-sectional studies were carried out in two phases. 489 medical records of patients with COVID-19 hospitalized at “Daniel A. Carrión” Hospital in Huancayo (located at 3,250 meters above sea level) were revi [...]

768 4301

Open Access Review

Mechanisms of Action of Ready-to-Use Therapies in Hematologic Malignancies: From Clinical Impact to Future Directions

Received: 23 January 2025;  Published: 06 June 2025;  doi: 10.21926/obm.transplant.2502250

Abstract

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection, modification, and expansion, off-the-shelf therapies can be prepared in advance, substantially reducing treatment timelines, decreasing costs, and improving global acces [...]

999 4293

Open Access Original Research

Impact of Normalization Methods on Metagenomic Characterization of Amaranthus Cruenthus var. Pribina-Associated Microbiomes Under Cadmium Stress

Received: 17 January 2025;  Published: 15 July 2025;  doi: 10.21926/obm.genet.2503303

Abstract

The study of endophytic and rhizosphere microbiota offers considerable potential for applications in agriculture, biotechnology, and bioremediation, given the phytoremediation capacity of Amaranthus cruentus var. Pribina performed a detailed analysis of the root and rhizosphere microbial communities under cadmium (Cd) stress. Although metagenomics provides powerful tools for microbial community profiling, the reproducibility and interpretability of the results are strongly influenced by the data processing strategi [...]

1253 4278

Open Access Original Research

Dependence Levels and Oral Functionality in Older People

Received: 03 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.geriatr.2502316

Abstract

It has been suggested that an individual's overall functional capacity gradually declines with age. It has been reported that a decline in oral functionality increases the risk of sarcopenia and frailty, which contributes to the decrease in functional capacity. In Chile, the Preventive Medical Examination for Older Adults (EMPAM) is used to assess the functionality of that population; however, this examination does not include an evaluation of oral functionality. To address this gap, the Preventive Dental Examinati [...]

1149 4272

Open Access Interview

An Interview with Prof. Dr. Pedro Fonte

Received: 07 April 2025;  Published: 11 April 2025;  doi: 10.21926/rpse.2502008

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