by Jennifer S. Jewell  , Ashley Brooks-Russell  and Jenn Leiferman

Received: 11 November 2022;  Published: 29 January 2023;  doi: 10.21926/obm.icm.2301010

Postpartum depression (PPD) affects a notable number of women. While many of the risk and protective factors for PPD are specific to the mother, there are also factors that are related to the partner. However, the partner is often overlooked when assessing the landscape of PPD and potential treatment programs. This study sought to expand the knowledge on partner perceptions during the perinatal period. This online, cross-sectional survey of fathers who were in relationships with mothers who had given birth within t [...]

by Ramareddy V Guntaka

Received: 20 December 2018;  Published: 13 March 2019;  doi: 10.21926/obm.hg.1901014

Liver fibrosis leading to cirrhosis and cancer affects millions of people and causes thousands of deaths all over the world. Many signaling pathways could be targeted to block fibrosis but these are not successful. Reviewing recent literature and from our own studies we identified novel target, such as YB-1, which is implicated in inflammation, angiogenesis and accumulation of extracellular matrix (ECM). In addition we observed and showed that the end product of fibrosis, collagen gene, itself is a direct target fo [...]

by Alessia Bartolacci  , Fabrizio Stocchi  , Vilberto Stocchi  and Sabrina Donati Zeppa

Received: 17 November 2024;  Published: 08 April 2025;  doi: 10.21926/rpn.2502007

In recent years, there has been an alarming increase in the incidence of inflammatory bowel disease (IBD), which includes both Crohn's disease (CD) and ulcerative colitis (UC), particularly in Western countries. This chronic condition is intricately linked to the composition and health of the gut microbiota (GM) — a complex community of microorganisms residing in the gastrointestinal (GI) tract. Despite extensive research, the underlying pathogenesis of IBD remains poorly understood, making it a wide area of invest [...]

by Aini Hidayati Shahrir  and Gasim Hayder

Received: 27 October 2022;  Published: 14 February 2023;  doi: 10.21926/aeer.2301020

The pandemic has shown its effect on the world regarding health, economy, society, and environment. Whether it is a negative or positive impact, the period of this pandemic has a vast open platform for further studies. This review focused on the impact of the COVID-19 pandemic lockdown on water quality. It is hypothesized that due to the reduced amount of anthropogenic activity due to the global lockdown, the water quality of water resources increased and rejuvenated. This review showed the study period, methods an [...]

by Angela Horyacheva  , Samantha Shune  and Ashwini Namasivayam-MacDonald

Received: 11 August 2022;  Published: 07 November 2022;  doi: 10.21926/obm.geriatr.2204210

Stroke survivors often receive spousal support for post-stroke impairments. The quality of spousal caregiving and couples’ wellbeing can suffer from post-stroke relationship changes and caregiver burden. Because swallowing impairment (dysphagia) is common post-stroke and spouses providing dysphagia care may experience burden, it is also important to explore whether relationship changes post-stroke are associated with dysphagia outcomes. The purpose of this study was to describe stroke survivor-spouse relationships [...]

by Tomomi Kogiso  , Mutsuki Kobayashi  , Kuniko Yamamoto  , Yuichi Ikarashi  , Kazuhisa Kodama  , Makiko Taniai  , Nobuyuki Torii  , Kazunari Tanabe  , Hideki Ishida  , Shohei Fuchinoue  , Hiroto Egawa  , Masakazu Yamamoto  , Etsuko Hashimoto  and Katsutoshi Tokushige

Received: 08 February 2017;  Published: 06 April 2017;  doi: 10.21926/obm.hg.1702003

Background: Hepatitis C virus (HCV) infection frequently occurs in recipients of liver or kidney transplants (LT/KT). Interferon (IFN)-based therapies are used to treat HCV, but their efficacy is low. Methods: We report 24 patients who received HCV therapy after LT/KT. Design, Setting, and Participants-Twelve LT and 12 KT recipients (median age, 59 years; 15 males; 21 serological type 1) were enrolled, of whom eight (six with LT) were treated with IFN-based therapy. Twelve received direct-acting antiviral drugs [ [...]

by Tahere Mohammadpour  and Reza Mohammadzadeh

Received: 20 December 2023;  Published: 15 April 2024;  doi: 10.21926/obm.genet.2402227

Epilepsy, a prevalent neurological disorder, affects more than 50 million individuals worldwide and is characterized by recurring seizures. Nonsynonymous single nucleotide polymorphisms (nsSNPs) found within coding regions of epilepsy-related genes are believed to have significant impacts on protein function. This is due to their tendency to cause mutations in the encoded amino acids, which can subsequently lead to pathogenic alterations in protein structure and function. Consequently, nsSNPs have the potential to [...]

by Yoko Kawamura

Received: 15 May 2025;  Published: 30 October 2025;  doi: 10.21926/obm.geriatr.2504329

In Japan, a super-aging society, the development of Ikigai is considered the key to extending healthy longevity in national policy. Thus, activities provided by local governments are designed to encourage Ikigai. At this point, Ikigai has developed its conceptual understanding, which includes its distinctiveness from life purposes and other closely related concepts. Empirical studies using developed measurements have shown that Ikigai has an impact on the mental and physical health of older adults across countries [...]

by Jean-François Cadranel  and Jean-Baptiste Nousbaum

Received: 21 August 2019;  Published: 15 April 2020;  doi: 10.21926/obm.hg.2002045

The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-reviewed articles on the prevalence of SBP in ambulatory outpatients who visited the hospital for therapeutic paracentesis. Five such studies were available in the literature. It was found that the prevalence of SBP was in [...]

by G.-Fivos Sargentis

Received: 05 February 2025;  Published: 02 April 2025;  doi: 10.21926/rpse.2502007

This study investigates the relationship between entropy and societal dynamics, with a particular focus on the origins and implications of war. By using entropy as a measure of uncertainty and inequality, the research examines societal stability through patterns of stratification and wealth distribution. Employing simplified models of various wealth distributions, the study explores their effects on social stratification and the potential for conflict. Drawing on historical and contemporary examples, it delves into [...]