by Michael Fossel  and Kurt Whittemore

Received: 26 October 2020;  Published: 03 February 2021;  doi: 10.21926/obm.geriatr.2101156

Telomere elongation is protective of genomic stability, whereas telomere shortening increases genomic instability and thereby increases cancer risk. Long telomeres lower the risk of clinical cancer, while short telomeres are part of a causal cascade of intracellular events that result in oncogenesis and, ultimately, clinical cancer. Telomerase therapy is not only unlikely to result in an increased risk of cancer but is likely to lower the risk of cancer compared to age-matched patients not treated with telomerase t [...]

by Selma A. Augusta Quist Møller  , Sohrab Sami  and Shauna L. Shapiro

Received: 04 July 2018;  Published: 06 January 2019;  doi: 10.21926/obm.icm.1901002

Background: In this study, we performed a systematic review of randomized-controlled trials (RCTs) examining the health benefits of (mindful) self-compassion-based interventions (SCBIs) and studies which explicitly combine SCBIs and mindfulness-based interventions (MBIs). Based on the compelling evidence supporting the effectiveness of MBIs, we evaluated the potential use of MBIs and SCBIs to complement one another, and whether SCBIs may serve as supplementary, or preliminary interventions for individuals not fully [...]

by Erik B Karlsson

Received: 29 December 2019;  Published: 13 April 2020;  doi: 10.21926/rpm.2002009

Decoherence is a relatively recent concept in the field of quantum mechanics. Although the pioneers of the field must have understood that loss of phase coherence in quantum superpositions is the reason underlying the appearance of definite outcomes in the quantum measurement problem, the latter was not treated in terms of decoherence until sixty years after the formulation of quantum mechanics as described in a report by Joos and Zeh in 1983 [1]. However, soon after, the theory was developed in further detail, and [...]

by J. Kim Penberthy  , Dinesh Chhabra  , Nina Avitabile  , J. Morgan Penberthy  , Ngan Le  , Yiqin Roger Xu  , Seara Mainor  , Natalie Schiavone  , Paul Katzenstein  , Janet E Lewis  and Leslie Hubbard

Received: 18 April 2018;  Published: 28 December 2018;  doi: 10.21926/obm.icm.1804039

Over the past few decades, there have been minimal advances in effective new behavioral or psychotherapeutic interventions for people living with autoimmune diseases such as systematic lupus erythematosus. This is problematic due to the severe, debilitating and potentially life-threatening nature of these diseases. Mindfulness based interventions, such as Mindfulness Based Stress Reduction, have demonstrated effectiveness in a wide range of patient populations and we hypothesize such treatment would also benefit pa [...]

by Ana Luísa Tomás  and Olga Matos

Received: 21 August 2018;  Published: 13 November 2018;  doi: 10.21926/obm.genet.1804049

Pneumocystis jirovecii pneumonia (PcP) remains a major cause of respiratory illness among immunocompromised patients. PcP is difficult to diagnose, in particular in non-HIV-infected patients, due to the lack of associated specific clinical data. Since P. jirovecii could not be cultivated for many years, microscopic visualization of cystic or trophic forms in respiratory specimens based on cytochemical or immunofluorescence staining are the standard procedure to identify this fungus. Polymerase chain reaction (PCR)- [...]

by Alison Schmidt  and Anthony Shanks

Received: 16 June 2021;  Published: 27 September 2021;  doi: 10.21926/obm.genet.2103138

Cell-free DNA has emerged as the most reliable, non-invasive prenatal screening tool for fetal aneuploidies. It has come to replace the previously widely used quadruple screen offered in the second trimester of pregnancy. This change comes with improved detection for aneuploidy but also presents potential gaps in prenatal diagnosis including detection of open fetal defects and emerging data on prediction of adverse pregnancy outcomes. This review article provides a historical summary of the quadruple marker screen [...]

by Randolph James  , Amy Lawson Moore  , Dick M Carpenter II  , Terissa Michele Miller  and Christina Ledbetter

Received: 29 April 2019;  Published: 06 September 2019;  doi: 10.21926/obm.icm.1903054

Background: The current study examined a multifaceted anti-neuroinflammatory intervention that included physical exercise, mental exercise, grain-free/sugar-free diet, anti-inflammatory nutritional supplements, sleep optimization, and stress management within the context of a functional medicine practice for five patients with varying levels of cognitive impairment. Methods: In a prospective chart review, we examined impact measures including assessment of (1) cognitive skills, (2) brain connectivity, and (3) daily [...]

by Jamie Zhen  and M. Ines Pinto-Sanchez

Received: 17 May 2020;  Published: 10 July 2020;  doi: 10.21926/obm.neurobiol.2003065

Celiac disease (CeD) is an immune-mediated enteropathy triggered by gluten ingestion and affects nearly 1% of the population worldwide. CeD has typically been associated with gastrointestinal symptoms such as diarrhea and abdominal pain; however, its extra-intestinal manifestations are becoming widely recognized. In particular, CeD patients may present with various neurological manifestations and oftentimes, without evidence of gastrointestinal symptoms. The pathophysiology behind these manifestations is not well k [...]

by Ugo Chiocchini  and Giovanni Savarese

Received: 14 May 2019;  Published: 05 September 2019;  doi: 10.21926/jept.1903003

Background: The Regione Lazio-Direzione Regionale dello Sviluppo Economico e delle Attività Produttive (RL–DRSEAP), carrying out its public functions to govern the use of mineral resources (including thermal water), planned the exploitation of the Viterbo hydrothermal system on the basis of a conceptual hydrogeological model (CHM). The CHMs of the Viterbo area and that of the neighboring Tuscany region, characterized by the same geological and hydrogeological setting, are discussed, suggesting the unreliability of [...]

by Floris Taminiau  and Bob van der Zwaan

Received: 04 August 2022;  Published: 10 October 2022;  doi: 10.21926/jept.2204032

In the Netherlands, an important way to contribute toward achieving climate goals is the large-scale deployment of wind turbines in the North Sea. The North Sea is a unique location for offshore wind power thanks to its strong winds, shallow waters, and proximity to large energy users. Wind turbines generate electricity by extracting kinetic energy from the atmosphere. This kinetic energy is replenished at a finite rate through the mixing of atmospheric layers. The replenishment rate sets a physical limit to the am [...]