by Kelly Armstrong  , Raman Gokal  and Todd Todorsky

Received: 25 March 2019;  Published: 25 September 2019;  doi: 10.21926/obm.icm.1903056

Background: Direct Current (DC) micro-current point stimulation (MPS) is increasingly recognized as a therapy for chronic pain and stress management. However, there remains limited evidence as to the therapeutic value of MPS in chronic post surgical pain (CPSP) management related to C-Section scars. Objectives: We aimed to determine the effect and magnitude that MPS has when applied to C-section scars and its effects on a wide variety of non-specific chronic post surgical pain syndromes. Study Design: This was a co [...]

by Thibault Deschamps

Received: 24 July 2019;  Published: 24 September 2019;  doi: 10.21926/obm.icm.1903055

Let’s consider the issues of exercise and cognitive function from a different angle, by moving from sitting to standing for instance. Not only does seeing anything from different perspectives reflect our cognitive flexibility [1], it also has a direct impact on the executive performance. Interestingly, recent studies reported a smaller Stroop effect when standing than when sitting [2-3] or after stepping backward [4], evidencing that the body posture enhances selective attention and cognitive control. Hence a call [...]

by Vanessa G. Oliveira  , Ana Filipa Saraiva  , Fátima Costa  and Aida Botelho de Sousa

Received: 27 February 2019;  Published: 24 September 2019;  doi: 10.21926/obm.transplant.1903086

Nowadays, hematopoietic stem cell transplantation (HSCT) is a common procedure in hematology units within reference centers, mainly for the treatment of hematological malignancies such as multiple myeloma, lymphoma, and acute leukemia. Nevertheless, HSCT has much wider applications, namely in autoimmune diseases, congenital metabolic defects, and hemoglobinopathies. Thalassemia major and sickle cell disease make up the most frequent hereditary hemoglobinopathies worldwide. Despite advances on the prevention and tre [...]

by Maria E. Pushpanathan  , Andrea M. Loftus  , Natalie Gasson  , Meghan G. Thomas  and Romola S. Bucks

Received: 13 May 2019;  Published: 23 September 2019;  doi: 10.21926/obm.geriatr.1903075

Background: Both disrupted sleep and cognitive impairment are frequent in Parkinson’s disease (PD), but the evidence for a relationship between self-reported sleep disturbance and cognitive symptoms has been equivocal. If sleep symptoms differentially predict cognition in different subtypes, effects may be obscured in a general PD sample. Objective: First, to determine whether the associations between participant and disease variables, sleep symptoms and cognitive performance vary by subtype (younger and olde [...]

by Rastislav Burda  , Viera Danielisová  and Jozef Burda

Received: 03 June 2019;  Published: 20 September 2019;  doi: 10.21926/obm.neurobiol.1903041

Background: Many experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. However, the translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-Methyltin (TMT) poisoning and short-term transient cerebral ischemia cause similar damage, especially, to selectively vulnerable brain regions such as hippocampal CA1 and CA3. Methods: Using dual conditioning, we activated the full [...]

by Konstantinos Magganas  , Sophia Delicou  , Aikaterini Xydaki  and Zoi Pallantza

Received: 19 May 2019;  Published: 17 September 2019;  doi: 10.21926/obm.genet.1903095

Thalassemia syndromes are a group of hemoglobinopathies characterized by gene defects that disrupt normal hemoglobin production. Thalassemia intermedia (TI) is referred to as a group of disorders with a less severe form of the disease compared to thalassemia major. We present a case of a 60-year-old woman who was referred to a hematologist for chronic anemia and splenomegaly.

by Laura Suarez  , Reem M.A. Shafi  and Maria I. Lapid

Received: 14 May 2019;  Published: 16 September 2019;  doi: 10.21926/obm.geriatr.1903074

Background: Dementia is a progressive and debilitating condition that affects millions of patients in the United States with an enormous impact on healthcare costs, caregivers, and society. Patients with dementia often experience dementia-related neuropsychiatric disturbances, commonly known as Behavioral and Psychological Symptoms of Dementia (BPSD) and more recently Neuropsychiatric symptoms (NPS) in dementia. These symptoms include verbal and physical agitation, aggression, disinhibition, affect lability, apathy [...]

by Joseph S. D'Arrigo

Received: 22 August 2019;  Published: 16 September 2019;  doi: 10.21926/obm.neurobiol.1903040

Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, mainly class B type I (i.e., SR-BI), and crosses the blood-brain barrier. Documented similarities in [...]

by Johanne Traeger-Synodinos  and François Rousseau

Received: 06 September 2019;  Published: 11 September 2019;  doi: 10.21926/obm.genet.1903094

We present here the content and articles of this special issue on genetic screening, putting them in perspective with the field and between themselves.

by Siavash Jafari  , Mariko Vaughan  , Souzan Baharlou  , Pooria Ghadiri  , Nazila Hassanabadi  and Ashkan Nasr

Received: 11 August 2019;  Published: 09 September 2019;  doi: 10.21926/obm.neurobiol.1903039

Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed, Current Contents, Scopus, EMBASE, MEDLINE, the Effect Review Summary Database and the ACP Journal Club until May 2018. A randomized clinical trial examined the impact of case management on the association of PLHA with c [...]