by Sonia Baccetti  , Elisabetta Barbara Cortesi  , Maria Valeria Monechi  , Mariella Di Stefano  , Barbara Cucca  , Tommaso Conti  , Antonella Traversi  , Filippa Terranova  , Sylvie Yvonne Barberousse  , Roberto Montelatici  , Federica Sabatini  , Catia Vuono  , Christian Bini  , Elio Rossi  and Francesca Martella

Received: 27 September 2018;  Published: 25 October 2019;  doi: 10.21926/obm.icm.1904061

Background: Pain and vasomotor symptoms are the common side effects experienced by breast cancer patients undergoing conventional oncology treatments. Traditional Chinese Medicine might represent a key treatment option for these side effects in a multidisciplinary pathway. Aim: The present study with a retrospective design was aimed at confirming the effectiveness of acupuncture, plum blossom, and auriculotherapy in reducing hot flashes and the intensity and frequency of pain in women with breast cancer. Materials [...]

by Renato Pol  , Tiziana Ruggiero  , Luisa Giaccone  , Davide Camisassa  , Andrea Spadafora  , Giulia Rivetti  , Marta Bezzi  and Stefano Carossa

Received: 14 June 2019;  Published: 21 October 2019;  doi: 10.21926/obm.transplant.1904088

Objective: Hematopoietic stem cells transplant (HSCT) requires being preceded by chemotherapy and radiotherapy. The neutropenia and thrombocytopenia which follows may be the possible cause of post-transplant complications. It is required that the patient undergoing transplantation is eradicated of any possible infectious focus. Currently, a uniform protocol for the oral management of these patients is unavailable. Methods: The approach for the dental management of each patient was designed as a more selective proto [...]

by Zena Aldridge  and Karen Harrison Dening

Received: 19 September 2019;  Published: 18 October 2019;  doi: 10.21926/obm.geriatr.1904081

The population of the United Kingdom is ageing. In 2017 approximately 18% of the UK population were aged 65 years or over and projected to grow to almost 21% by 2027 according to the Office of National Statistics. Increased age is the greatest risk factor for developing dementia. It is estimated that there are 850,000 people living with dementia in the UK and if current figures relating to incidence and prevalence are realised, this will increase to 1 million people by 2025 and 2 million by 2051. The National Healt [...]

by Francesco Sivelli  , Elio Rossi  , Sonia Baccetti  , Mariella Di Stefano  , Eugenia Gallo  and Fabio Firenzuoli

Received: 27 September 2018;  Published: 18 October 2019;  doi: 10.21926/obm.icm.1904060

Phytotherapy, which is defined as the use of titrated herbal extracts in clinical practice, has been receiving increasing interest in the scientific community recently. In the present report, information regarding the most important mechanisms underlying the drug-drug interactions (DDI) and herb-drug interactions (HDI) has been discussed briefly. Furthermore, the best known and relevant interactions of Ginkgo biloba, Citrus paradisi (Grapefruit Juice), Silybum marianum (Milk Thistle), Hypericum perforatum (St. John [...]

by Xuhua Xia

Received: 09 June 2019;  Published: 17 October 2019;  doi: 10.21926/obm.genet.1904097

Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation initiation often being rate limiting. Initiation signals such as Shine-Dalgarno (SD) sequences and start codon are decoded by anti-SD sequences and initiation tRNA, respect [...]

by Bas T Röttgering  and Karoly Szuhai

Received: 14 May 2019;  Published: 14 October 2019;  doi: 10.21926/obm.genet.1904096

Insulin-like growth factor 2 (IGF2) is a strong mitogenic peptide with an imprinted gene that is primarily involved in fetal development. It is highly expressed in the fetus where it is involved in fetal growth and tissue differentiation. However, postnatally, the expression of IGF2 decreases despite higher expression levels in the blood as compared with that of IGF1. In adults, the physiological function of IGF2 is poorly understood; however, the possibility of a metabolic function exists. Although the expression [...]

by Emma Wolverson  , Heather Birtles  , Esme Moniz-Cook  , Ian James  , Dawn Brooker  and Frances Duffy

Received: 08 September 2019;  Published: 11 October 2019;  doi: 10.21926/obm.geriatr.1904080

Background: Behavioural and Psychological Symptoms of Dementia and Challenging Behaviour in dementia are just two of a variety of terms for a complex paradigm that covers the most distressing and costly aspects of the condition. The terminology used to describe these aspects can influence what is measured as outcomes and what is considered as evidence of improvement. Unhelpful or outmoded narratives could be a barrier to developing innovative interventions or in determining what works for whom. This UK study explor [...]

by Lia Ofek  , Daniella Goder  and Meital Zilberman

Received: 31 July 2019;  Published: 11 October 2019;  doi: 10.21926/rpm.1904004

Background:Wound management is an important field in medical care, as annually, millions of wounds require treatment worldwide. Soy protein is highly biocompatible, easily processed, and a relatively cheap natural polymer, which can be used for wound dressing applications. Methods:In this study, solvent cast soy protein films, plasticized by glycerol and cross-linked by glyoxal, were thermally treated and their mechanical properties were evaluated as a function of various processing parameters. Samples were then lo [...]

by Robert J. Brent

Received: 31 July 2019;  Published: 10 October 2019;  doi: 10.21926/obm.geriatr.1904079

Background: The 2018 Alzheimer's Disease Facts and Figures special report includes two new guidelines for measuring dementia symptoms. The first requires that a biomarker (biological factor) be added to a doctor's clinical judgment of the cause of symptoms when determining whether dementia is present. The second involves identifying four stages of dementia: normal cognition, preclinical, MCI and dementia. Now only those with defining brain pathologies and significant symptoms will be judged to be persons with stage [...]

by Elizabeth M. Goldberg  , Cameron J. Gettel  , Kelsey Hayes  , Renee R. Shield  and Kate M. Guthrie

Received: 21 August 2019;  Published: 10 October 2019;  doi: 10.21926/obm.geriatr.1904078

Background: Three million US emergency department (ED) visits occur for falls each year. The mortality of falls is increasing and only one fourth of older adults report their fall to their primary care provider, suggesting that valuable preventative opportunities are missed. A fall prevention intervention initiated in the ED immediately after a fall has the potential to reduce subsequent falls, but ED providers lack the time and resources to complete fall risk assessments on their patients. GAPcare, the Geriatric A [...]