by Caymen M. Novak  , Eric N. Horst  , Shreya Raghavan  and Geeta Mehta

Received: 17 June 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903092

Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, and metastasis, and has been linked to the mechanotransduction of breast cancers. However, it is not currently known if shear stress mediated mechanotransduction is affected by COX-2. Therefore, in this report, we hypothesized that COX-2 m [...]

by Damien Bouvier  and Yves Giguère

Received: 01 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903093

Newborn screening (NBS) for inborn errors of metabolism (IEM) was introduced more than 50 years ago with the testing of phenylketonuria (PKU) using blood spots deposited on a filter paper after heel prick. NBS aims to identify early after birth inherited disorders for which clinical management and pre-symptomatic treatment will significantly decrease morbidity and mortality. While NBS for a few other disorders was implemented in some specific jurisdictions over the following decades, it is with the introduction of [...]

by Randolph James  , Amy Lawson Moore  , Dick M Carpenter II  , Terissa Michele Miller  and Christina Ledbetter

Received: 29 April 2019;  Published: 06 September 2019;  doi: 10.21926/obm.icm.1903054

Background: The current study examined a multifaceted anti-neuroinflammatory intervention that included physical exercise, mental exercise, grain-free/sugar-free diet, anti-inflammatory nutritional supplements, sleep optimization, and stress management within the context of a functional medicine practice for five patients with varying levels of cognitive impairment. Methods: In a prospective chart review, we examined impact measures including assessment of (1) cognitive skills, (2) brain connectivity, and (3) daily [...]

by Anita Modi  and Sherif Beniameen Mossad

Received: 07 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.transplant.1903085

Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of malignancy has led to markedly reduced tumor burden and improved patient survival, sparking curiosity about their potential role in the treatment of other chronic inflammatory states, including infectious diseases. While [...]

by Ugo Chiocchini  and Giovanni Savarese

Received: 14 May 2019;  Published: 05 September 2019;  doi: 10.21926/jept.1903003

Background: The Regione Lazio-Direzione Regionale dello Sviluppo Economico e delle Attività Produttive (RL–DRSEAP), carrying out its public functions to govern the use of mineral resources (including thermal water), planned the exploitation of the Viterbo hydrothermal system on the basis of a conceptual hydrogeological model (CHM). The CHMs of the Viterbo area and that of the neighboring Tuscany region, characterized by the same geological and hydrogeological setting, are discussed, suggesting the unreliability of [...]

by Y. Ben-Aryeh

Received: 29 July 2019;  Published: 04 September 2019;  doi: 10.21926/rpm.1903003

In this article, microsphere super-resolution, which are beyond the Abbe classical limit, are described. The conversion of evanescent waves into propagating waves is analyzed by using the geometry of the microsphere. In microsphere experiments, a nanojet is produced near the focal plane, where its width is smaller than the Abbe limit and remains unchanged in the axial direction for certain wavelengths. The interference between the evanescent waves being converted into propagating waves and the nanojet leads to an i [...]

by Salim Hamdani  and Daniel Azoulay

Received: 18 April 2019;  Published: 04 September 2019;  doi: 10.21926/obm.transplant.1903084

The privileged liver, due to its immunological status, is referred to as a tolerogenic organ. However, this alone does not explain the introduction of tolerance after single or combined liver transplantation (kidney, heart, pancreas, and intestine); other factors, such as recipient’s age, donor’s hepatic volume, iron metabolism, biomarkers, or imprint of cytomegalovirus infection, appear to be involved in the identification of patients who are likely to be tolerant to their graft. All the afore-stated factors appea [...]

by Siti Hana Nasir  , Olga Troynikov  , Dawn Wong Lit Wan  and Zhen Zheng

Received: 25 February 2019;  Published: 02 September 2019;  doi: 10.21926/obm.icm.1903053

Background: Pressure and thermal therapy gloves are the two types of therapeutic gloves that are commonly used to relieve symptoms and improve hand function in patients with hand arthritis. However, no published clinical study exists indicating ideal pressure and thermal stimuli for the gloves. Understanding user thresholds for the pressure and thermal stimuli is crucial to improve therapeutic outcomes, wearer's comfort, and adherence to the therapy. There were two main aims of this pilot study, firstly to examine [...]

by Alessandro Luigi Rossi  , Vincenzo Capilupi  , David Palombo  , Luigi Tagliatesta  , Tecla Terenzio  , Marco Vitali  and Matteo Chiapasco

Received: 29 April 2019;  Published: 30 August 2019;  doi: 10.21926/obm.hg.1903035

OBJECTIVES To review current literature analysing possible secondary complications in response to the administration of paracetamol and codeine as analgesics in the dental field. To discuss a case of secondary acute pancreatitis triggered by the administration of both active ingredients. MATERIALS AND METHODS A 28-year-old patient, without any pancreatic or hepatobiliary condition was diagnosed with acute pancreatitis 3 hours after taking paracetamol 500mg and codeine 30mg prescribed as pain-relief therapy after ex [...]

by Mauro Turrin

Received: 15 March 2019;  Published: 29 August 2019;  doi: 10.21926/obm.hg.1903034

Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP). Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February 2019 and those related to new drugs responsible for acute pancreatitis. Results: we found about thirty reports of eosinophilic pancreatitis associated or not with hypereosinophilia and gastro-intestinal manifestations. [...]