by Clément Dumont  , Madeleine Lefèvre  , Quiterie Aussedat  , Pierre-Louis Régnier  , Alexandra Masson-Lecomte  , Evanguelos Xylinas  , Hélène Gauthier  , Virginie Fossey-Diaz  , Amélie Arégui  and Stéphane Culine

Received: 23 July 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104183

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because of their perceived frailty. Therefore, in order to evaluate the effectiveness of C-NAC in elderly patients with MIBS, we retrospectively reviewed the medical files of [...]

by Michelle Szucs  , Miguel Angulo  , Carlos Costa  and Mª Carmen Márquez

Received: 12 May 2021;  Published: 08 November 2021;  doi: 10.21926/rpm.2104045

Five different commercial proteases (Alcalase 2.4L, Flavourzyme 1000L, Neutrase, Protamex, and PTN) were evaluated for the simultaneous recovery of protein and lipids through hydrolysis. The hydrolysis reaction was monitored using the pH-stat procedure, in which samples were collected after 240 min of hydrolysis using each enzyme. The samples were analyzed for the degree of hydrolysis, protein hydrolysate, collagen, lipids, and fatty acids. A clear relationship was observed between the degree of hydrolysis and the [...]

by Francesco E. Negro  and Francesco V. Marino

Received: 26 April 2021;  Published: 07 November 2021;  doi: 10.21926/obm.icm.2104045

The 19th century saw an explosion of serious epidemic diseases, such as smallpox and scarlet fever, which led to the development of an alternative system of medicine called homeopathy. Under this system, S. Hahnemann developed a rigorous methodology based on repeated observations on the field, leading to successful results. The aim of this work is to depict the birth and evolution of his thought. The correct understanding and application of this methodology became the reference model for subsequent generations of h [...]

by Francesco E. Negro  and Francesco V. Marino

Received: 26 April 2021;  Published: 07 November 2021;  doi: 10.21926/obm.icm.2104044

The 19th century saw an explosion of serious epidemic diseases, such as smallpox and scarlet fever, which led to the development of a new medical system called homeopathy. Under this system, S. Hahnemann developed a rigorous methodology based on repeated observations on the field, leading to successful results. The aim of this work is to depict the birth and evolution of his thought. The correct understanding and application of this methodology became the reference model for subsequent generations of homeopaths, wh [...]

by Karen E. Atler  , Deana Muñoz  , Carly Knowles  , Angie Noe  , Christine A. Fruhauf  , Kathryn McGirr  , Tracy L. Nelson  and Arlene A. Schmid

Received: 18 May 2021;  Published: 05 November 2021;  doi: 10.21926/obm.icm.2104043

If proper self-management behaviors are not maintained, diabetes may lead to reduced quality of life (QoL), decreased engagement in everyday activities, disabling health complications, and even death. Less advantaged adults with limited income, lower education, and fewer resources find diabetes self-management (DSM) particularly challenging due to healthcare and social inequalities. DSM education is important to understanding diabetes-related behaviors and improving QoL. There are few evidence informed DSM educatio [...]

by Foad Haeri  , Deepak Tapriyal  , Christopher Matranga  , Dustin Crandall  and Angela Goodman

Received: 05 September 2021;  Published: 05 November 2021;  doi: 10.21926/jept.2104046

Contact angles were measured for CO2-brine interactions on 20 different rocks that represent the properties of various CO2 storage depositional environments to characterize the wettability during geologic carbon storage. Three different CO2 phases (gaseous, liquid, and supercritical) were considered to investigate the effect of pressure and temperature. Bubbles were studied in two groups of larger and smaller than 500 μm, the latter being more relevant to pore scale. Variation was observed among contact angle measu [...]

by Erina White  , Farzane Mohseni  and Meisam Amani

Received: 28 August 2021;  Published: 04 November 2021;  doi: 10.21926/aeer.2104028

The vitality of the Great Barrier Reef (GBR) is threatened by many human-made impacts. Monitoring this ecosystem makes it possible to study the general condition and the health of the GBR. However, due to the large extent of the GBR and limited accessibility in the ocean environment, mapping and monitoring this ecosystem has been always challenging task and connived. In this regard, Remote Sensing (RS) is an effective technique that provides valuable information for mapping and monitoring this ecosystem. In an atte [...]

by Masahiro Sato  , Yuki Kiyokawa  , Emi Inada  , Eri Akasaka  , Satoshi Watanabe  and Issei Saitoh

Received: 15 March 2021;  Published: 04 November 2021;  doi: 10.21926/obm.transplant.2104155

Although the aging process expands the adipose tissue habitation in mice and due to its close association with the female reproductive system, it can be easily exposed surgically under anesthesia when reproductive organs (including ovary, oviduct, and part of the uterus) are pulled and exposed onto the dorsal skin. This study aimed to consider the suitability of adipose tissue as a target for manipulation, particularly for the grafting of cells or small-sized tissue sections due to its ease of handling. Subsequentl [...]

by Richard B. Kreider

Received: 01 April 2021;  Published: 03 November 2021;  doi: 10.21926/obm.icm.2104041

Obesity has historically been thought to simply be related to an imbalance between energy intake and expenditure. Weight loss recommendations have traditionally focused on reducing energy intake, maintaining either a high-carbohydrate low-fat diet or vice versa, and increasing physical activity typically through low to moderate intensity exercise. More recently, genetic, physiological, and behavioral factors have also been found to play a significant role in the etiology of obesity. For this reason, the prevention [...]

by Sarah Long  , Roanna Lobo  , Peter O'Leary  and Jan E. Dickinson

Received: 07 September 2021;  Published: 03 November 2021;  doi: 10.21926/obm.genet.2104142

Non-invasive prenatal testing (NIPT) for a panel of 25 single gene disorders became available in Western Australia in 2020 and potentially may be able to test for panels of hundreds of disorders as is the case with reproductive carrier screening. How this information would be used by parents in a population screening model is unknown. We used a phenomenological approach to explore retrospectively whether mothers of children with single gene or chromosomal disorders would have wanted to know about their child’ [...]