by Ivan Stoyanov  , Penka Vasileva  , Teodora Staykova  , Teodora Popova  and Evgeniya N. Ivanova

Received: 22 June 2023;  Published: 14 December 2023;  doi: 10.21926/obm.genet.2304208

Data from the present study indicate that the neonicotinoid insecticides Nuprid 200 SL (with the active substance imidacloprid) and Calypso 480 SC (with the active substance thiacloprid) reduce the mitotic activity by inhibiting cell division and increasing chromosomal aberrations in the cells of the root apical meristem of Allium cepa L. The tested solutions of pesticides cause a wide range of anomalies associated with disorders in forming the cell's division apparatus and the integrity of chromosomes. The compara [...]

by Masahiro Sato  , Kazunori Morohoshi  , Masato Ohtsuka  , Shuji Takabayashi  , Emi Inada  , Issei Saitoh  , Satoshi Watanabe  and Shingo Nakamura

Received: 17 September 2023;  Published: 12 December 2023;  doi: 10.21926/obm.genet.2304207

Gene-engineered animals created using gene-targeting technology have long been recognized as beneficial, valid, and valuable tools for exploring the function of a gene of interest, at least in early 2013. This approach, however, suffers from laborious and time-consuming tasks, such as the production of successfully targeted embryonic stem (ES) cells, their characterization, production of chimeric blastocysts carrying these gene-modified ES cells, and transplantation of those manipulated blastocysts to the recipient [...]

by Samson Adedeji Adejumo  , Angus Nnamdi Oli  , Adekunle Babajide Rowaiye  , Nwamaka Henrietta Igbokwe  , Chinelo Kene Ezejiegu  and Zwanden Sule Yahaya

Received: 11 April 2023;  Published: 11 December 2023;  doi: 10.21926/obm.genet.2304206

Over the past few decades, probiotics have emerged as a viable medical tool for preventing and/or treating diseases. This narrative review provides recent findings on Probiotics and their benefits on the host immune system. It also highlights the specific mechanisms through which probiotics mediate those benefits. The study also explores the topical or systemic probiotic administration method. Authors screened databases like Google Scholar, Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure [...]

by Lyudmila N. Voloshina  , Viktor L. Kondakov  , Karina E. Panasenko  , Lyudmila K. Buslovskaya  and Dmitry V. Shcherbin

Received: 21 September 2023;  Published: 11 December 2023;  doi: 10.21926/obm.genet.2304205

According to modern research, there is a high risk of motor development disorders in children 6-7 years old with autism spectrum disorders. This determines the relevance of studying the problem of individual differences in motor development of children 6-7 years old with autism spectrum disorders, the need for objective assessment of its level, and the determination of group and individual strategies for correction of motor development. The study identifies and evaluates the motor development problems of 6-7-year-o [...]

by Leila Zirak  and Reza Khakvar

Received: 31 August 2023;  Published: 04 December 2023;  doi: 10.21926/obm.genet.2304204

Russian olive trees showing witches’-broom disease symptoms in urban green spaces and orchards in northwest Iran were sampled for phytoplasma detection. PCR assays and Sanger sequencing of 16S rRNA gene confirmed that ‘Ca. Phytoplasma asteris’ was associated with Russian olive witches’-broom disease. For genomic characterization of phytoplasma associated with disease, the total DNA of an infected tree was analyzed by Illumina next-generation sequencing (NGS). The NGS analysis generated 46011 [...]

by Maria Gladysheva-Azgari  , Natalia Slobodova  , Eugenia Boulygina  , Svetlana Tsygankova  , Fedor Sharko  and Irina Mitrofanova

Received: 16 October 2023;  Published: 24 November 2023;  doi: 10.21926/obm.genet.2304203

In this study, we report the complete chloroplast genome of Actinidia arguta var. purpurea. The chloroplast genome is 157,369 bp long as the circular (GC ratio is 37.22%). It has four subregions: a large single-copy (LSC) region of 88,609 bp, a small single-copy (SSC) region of 20,470 bp, and two inverted repeat regions (IRs) of 24,145 bp in each. The chloroplast genome of A. arguta var. purpurea contains a total of 113 unique genes, which are 79 protein-coding genes, 4 rRNA genes, and 3 [...]

by Sumant Chavda  , Subhranshu Sekhar Kar  and Alyaa Kamal Al Ramah

Received: 05 July 2023;  Published: 30 October 2023;  doi: 10.21926/obm.genet.2304202

Progressive pseudo-rheumatoid dysplasia (PPRD) is an uncommon genetic condition inherited in an autosomal recessive mode caused by a mutation in the WNT1-inducible signaling pathway protein 3 (WISP3) located on chromosome 6q21. In this condition, the articular cartilage gradually deteriorates, causing severe discomfort, stiffness, and joint deformities with a relatively high prevalence in Middle Eastern countries. Camptodactyly and platyspondyly are the standard features found in this condition. We present a very y [...]

by José Ramón Alonso-Fernández

Received: 21 March 2023;  Published: 30 October 2023;  doi: 10.21926/obm.genet.2304201

The personal experience of 36 years in charge of the Newborn Screening Laboratory in Galicia and the consequences of the recent advancement of sampling from 3 days to 24 hours of the newborn's life are reviewed. The implication in the results of the assay of reducers in urine with the Mandelin reagent and its alternatives is commented. The implication in the effects of TSH in blood and the possible ways of dealing with the situation. Since 1978, the Newborn Screening Program in Galicia has maintained the urine samp [...]

by Solaf Alaakel  and Youssef. AL-Ammouri

Received: 29 July 2023;  Published: 26 October 2023;  doi: 10.21926/obm.genet.2304200

The experiment was carried out at the laboratories of the National Commission for Biotechnology in Syria during the period 2020-2022 to detect the somaclonal genetic variation occurring in callus cultures at different ages and to compare them with the In vitro growing plants and introduced species of Rose Periwinkle that grew up in the Syrian environment, in addition, exploring the effect of abiotic stresses in causing genetic variations in callus, by the Inter Simple Sequence Repeats technique (ISSR) using 21 prim [...]

by Nadia A. Abdelmegeed Abdelwahed

Received: 24 September 2023;  Published: 24 October 2023;  doi: 10.21926/obm.genet.2304199

In the contemporary landscape, nurturing genomic entrepreneurial attitudes and intentions poses a substantial challenge for healthcare organizations. The present paper examines the factors affecting attitudes towards genomic technology and entrepreneurial intentions among Egyptian healthcare professionals. The study applied a quantitative approach and collected cross-sectional data from 276 health professionals using convenience sampling. Using structural equation modeling (SEM) through SmartPLS 4, the findings sug [...]