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Table of Content

Open Access Original Research

Development of Methods for Transplanting Human Islet within Macroencapsulation Device that Reverse Diabetes in Mice

Douglas Sobel and

Wanxing Cui

Received: 09 October 2025; Published: 20 March 2026; doi: 10.21926/obm.transplant.2601268

Abstract

Transplanting islets into the subcutaneous (SC) space rather than the portal vein is advantageous because this site is easier and safer to use. However, transplantation of islets directly or within planar devices has been unsuccessful in humans, mainly because of the low oxygen torr in t [...]

114 447

Open Access Review

Novel Therapies for the Treatment of Antibody Mediated Rejection in Solid Organ Transplantation: A Systematic Review

Alisia Chen and

Jeong M. Park

Received: 29 October 2025; Published: 24 February 2026; doi: 10.21926/obm.transplant.2601267

Abstract

Antibody mediated rejection (AMR) is a considerable cause of late allograft failure in solid organ transplantation. Conventional approaches, using plasmapheresis, intravenous immunoglobulin, rituximab, bortezomib, and eculizumab have been unsuccessful in improving graft survival. This review aims to [...]

385 1529

Open Access Editorial

Nutrition and Transplant Outcomes

Mohammed H. Moghadasian

Received: 27 January 2026; Published: 12 February 2026; doi: 10.21926/obm.transplant.2601266

Abstract

Dietary guidelines and Nutrient Reference Intakes are important tools for maintaining optimal health in the general population. Similar guidelines have also been developed by specific organ health associations to help their patient populations recover from disorders or prevent/delay clinical events [...]

315 754

Open Access Review

Balancing Preservation and Maximizing Utilization: A DCD Lung Procurement Strategy During Abdominal Normothermic Regional Perfusion

Chawannuch Ruaengsri ,

Miguel Alvarez-Cortes ,

Marc Leon ,

Manuel Quiroz-Flores ,

Masafumi Shibata and

Yasuhiro Shudo

Received: 30 June 2025; Published: 22 January 2026; doi: 10.21926/obm.transplant.2601265

Abstract

The increasing demand for organ transplantation has necessitated innovative strategies to maximize donor organ utilization, especially in donation after circulatory death (DCD) contexts. This article explores the integration of direct lung recovery with abdominal normothermic regional perfusion (A-N [...]

359 1344

Open Access Review

Machine Perfusion in DCD Lung Transplantation: Advances in Preservation and Donor Pool Expansion

Chawannuch Ruaengsri ,

Marc Leon ,

Miguel Alvarez-Cortes ,

Manuel Quiroz-Flores and

Yasuhiro Shudo

Received: 30 June 2025; Published: 21 January 2026; doi: 10.21926/obm.transplant.2601264

Abstract

To address the pressing shortage of donor lungs, Donation after Circulatory Death (DCD) transplantation has become a vital strategy for expanding the donor pool. Minimizing warm ischemic injury is crucial for optimizing organ viability and function. This review synthesizes current evidence on Normot [...]

466 1659

Open Access Editorial

Acknowledgment to Reviewers of OBM Transplantation in 2025

OBM Transplantation Editorial Office

Received: 03 January 2026; Published: 04 January 2026; doi: 10.21926/obm.transplant.2601263

Abstract

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2025. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize rev [...]

346 909

Open Access Review

Pharmacological Strategies to Enhance Bone Graft Integration: Emerging Agents and Molecular Pathways

Garzain Bint e Attar and

Mohd. Ashif Khan

Received: 15 May 2025; Published: 31 December 2025; doi: 10.21926/obm.transplant.2504262

Abstract

Bone grafting remains a cornerstone technique in orthopedic and reconstructive surgery, yet achieving successful graft integration continues to pose significant challenges, particularly in conditions such as osteoporosis, diabetes mellitus, and large bone defects. Traditional graft materials such as [...]

1353 3038

Open Access Review

Optimizing Donor Management Strategies for DCD Lung Procurement

Chawannuch Ruaengsri ,

Miguel Alvarez-Cortes ,

Marc Leon ,

Manuel Quiroz-Flores ,

Masafumi Shibata and

Yasuhiro Shudo

Received: 30 June 2025; Published: 30 December 2025; doi: 10.21926/obm.transplant.2504261

Abstract

Donation after circulatory death (DCD) offers a vital strategy to expand the donor lung pool; however, DCD lungs are uniquely susceptible to warm ischemic injury during procurement. This chapter reviews evidence-based and emerging donor management strategies aimed at mitigating ischemic damage and o [...]

498 1740

Open Access Review

Risk Assessment in Clinical Histocompatibility Testing: Challenges, Strategies, and Future Directions

Vikash Chandra Mishra ,

Dinesh Chandra and

Vimarsh Raina

Received: 15 July 2025; Published: 25 November 2025; doi: 10.21926/obm.transplant.2504260

Abstract

Though the role of clinical histocompatibility testing is fundamental to successful transplant, systematic risk assessment and mitigation strategies remain underutilised in this domain. This review addresses risk identification, analysis, and control measures across the pre-analytical, analytical, a [...]

580 1988

Open Access Original Research

Immunologic Response after COVID-19 Vaccination in Heart Transplant Recipients

Marina Zafranskaya ,

Olesya Shatova ,

Elizaveta Nazaranka ,

Alena Кurlianskaya ,

Galina Ivanchik ,

Irina Russkih ,

Alesia Vialichka ,

Marina Kolyadko ,

Tatyana Denisevich ,

Svetlana Kulinich and

Darya Nizheharodava

Received: 30 June 2025; Published: 21 October 2025; doi: 10.21926/obm.transplant.2504259

Abstract

To date, all large-scale randomized controlled trials for COVID-19 vaccines have excluded solid organ transplant recipients; therefore, the effectiveness and safety of COVID-19 vaccines in preventing coronavirus infection using COVID-19 vaccines in patients with heart transplants have not been suffi [...]

570 2430

Open Access Review

Antibody-Mediated Rejection in Kidney Transplantation: Immunopathogenesis, Innate–Adaptive Crosstalk, and Therapeutic Advances

Livia Maria Surdi ,

Maribel Dagher ,

Tamara Merhej ,

John Choi and

Jamil R. Azzi

Received: 17 April 2025; Published: 10 September 2025; doi: 10.21926/obm.transplant.2503258

Abstract

Antibody-mediated rejection (ABMR) remains a major barrier to long-term graft survival in kidney transplantation. Defined by the presence of donor-specific antibodies (DSAs) and characteristic histological changes, such as C4d deposition in peritubular capillaries, ABMR can present acutely, chronica [...]

1391 15153

Open Access Review

Precision Medicine in Liver and Lung Transplantation: Integrating Immunology, Regenerative Therapies, and Computational Advances

Tamer A. Addissouky

Received: 25 May 2025; Published: 09 September 2025; doi: 10.21926/obm.transplant.2503257

Abstract

Liver and lung transplantation remain among the most intricate and resource-intensive arenas in modern medicine, challenged by organ scarcity, immunological complexities, and the persistent threat of rejection. According to recent WHO and UNOS reports, approximately 100,000 patients globally await l [...]

936 4282

Open Access Review

The Essentials of Cell-Mediated Immunity Assays for the Management of CMV Infection after Solid Organ Transplantation

Alexis Guenette and

Valentina Stosor

Received: 12 March 2025; Published: 04 September 2025; doi: 10.21926/obm.transplant.2503256

Abstract

Provided that cell-mediated immunity (CMI) is known to be vital in managing CMV infection post-transplant along with improving methods to predict the development of cytomegalovirus (CMV) following transplant, CMV-specific-cell-mediated immunoassays have been developed, commercially and research base [...]

657 3501

Open Access Original Research

Duration of Hospitalization is Associated with the Gut Microbiome in Patients Undergoing Hematopoietic Stem Cell Transplantation: Early Results from a Randomized Trial of Home Versus Hospital Transplantation

Tessa M. Andermann ,

Ke Zeng ,

Sayal Guirales-Medrano ,

Adam Groth ,

Bhanu C. Ramachandran ,

Shan Sun ,

Alicia A. Sorgen ,

Lauren Hill ,

Amy T. Bush ,

Hongwei Liu ,

Corbin Jones ,

Jeffrey Roach ,

Brian P. Conlon ,

Gauri Rao ,

Nelson J. Chao ,

Anthony A. Fodor and

Anthony D. Sung

Received: 24 April 2025; Published: 25 August 2025; doi: 10.21926/obm.transplant.2503255

Abstract

Home-based hematopoietic stem cell transplantation (HCT) is an innovative care model with growing interest, but its impact on the gut microbiome remains unexplored in a randomized setting. We present interim results from the first randomized controlled trials (RCT) evaluating the effect of HCT locat [...]

1830 4928

Open Access Short Report

Donor-Derived Cell-Free DNA Assessment in a Predominantly Hispanic/Latino Lung Transplant Population: Single-Center Analysis

Lara Jones ,

David Ross ,

Andrew Doud ,

Navchetan Kaur ,

Sangeeta Bhorade and

Holly Keyt

Received: 31 March 2025; Published: 21 July 2025; doi: 10.21926/obm.transplant.2503254

Abstract

The demographics of lung transplant (LT) recipients show an evolution towards increased minority racial/ethnic representation, thanks to an increased focus on inclusion in LT access, healthcare and outcomes. Herein we assess potential differences in LT allograft health in a predominantly Hispanic/La [...]

680 3240

Open Access Case Report

Checkpoint Inhibition Followed by CAR-T Cell Therapy in Refractory PMLBCL: Immunologic Response and Fertility Preservation in a Young Patient

Filomena Emanuela Laddaga ,

Tommasina Perrone ,

Pellegrino Musto ,

Ilaria Farella ,

Stefano Martinotti and

Francesco Gaudio

Received: 22 February 2025; Published: 18 June 2025; doi: 10.21926/obm.transplant.2502253

Abstract

Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive B-cell malignancy that may exhibit resistance to standard chemoimmunotherapy. Novel immunotherapeutic strategies, including checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapy, are being explored in cases that [...]

738 3602

Open Access Original Research

Modern UNOS Data Reveals Septuagenarians Have Inferior Heart Transplant Survival

Manish Suryapalam ,

Jay Kanaparthi ,

Shineui Kim ,

Pedram Shafiei-Jahani ,

Armeen Barghi and

Mohammed Kashem

Received: 10 November 2024; Published: 11 June 2025; doi: 10.21926/obm.transplant.2502252

Abstract

While heart transplantation is increasingly performed in the United States for elderly patients, survival outcomes have primarily been analyzed in single-center studies. The few existing long-term studies have indicated no difference in HTx outcomes between patients ≥70 years and 60-69 years age, bu [...]

864 4275

Open Access Review

Integrating RNA-Seq Biomarkers and Diagnostic Algorithms to Improve Liver Transplant Outcomes: A Comprehensive Review

Elham Amjad and

Babak Sokouti

Received: 21 February 2025; Published: 09 June 2025; doi: 10.21926/obm.transplant.2502251

Abstract

Graft rejection, early allograft dysfunction (EAD), and poor diagnostic accuracy are some of the challenges that still need to be addressed, even though liver transplantation (LT) has the potential to help patients with end-stage liver disease (ESLD) significantly. Traditional procedures, such as li [...]

1282 8097

Open Access Review

Mechanisms of Action of Ready-to-Use Therapies in Hematologic Malignancies: From Clinical Impact to Future Directions

Filomena Emanuela Laddaga ,

Bruna Daraia ,

Pamela Pinto ,

Antonio D’amato ,

Stella D’oronzo ,

Stefano Martinotti and

Francesco Gaudio

Received: 23 January 2025; Published: 06 June 2025; doi: 10.21926/obm.transplant.2502250

Abstract

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches [...]

823 3795

Open Access Original Research

Illness Perceptions and Their Impact on Treatment Adherence among Renal Transplant Patients in the COVID-19 Pandemic

Moussa Hamidani ,

Salah Aberkane and

Moudjahid Aissaoui

Received: 17 December 2024; Published: 16 May 2025; doi: 10.21926/obm.transplant.2502249

Abstract

Although immunosuppressive drugs are essential and effective in improving the health status of renal transplant patients, they also make them more vulnerable to the risk of infection with COVID-19, which has become a significant concern for many patients. Perhaps this is what makes their way of thin [...]

753 4041

Open Access Review

What Is the Current Status of Single Lung Transplantation? A Literature Review

Camilo A. Velasquez ,

Simon Yaguare ,

Sabrina Gambini ,

Elizabeth McElhiney and

Suresh Keshavamurthy

Received: 19 September 2024; Published: 27 April 2025; doi: 10.21926/obm.transplant.2502248

Abstract

Lung transplantation (LTx) is the gold standard for the surgical treatment of end-stage lung disease. Ongoing discussions persist whether single lung transplantation (SLT) or bilateral lung transplantation (BLT) lead to better patient outcomes and quality of life. This study analyzed 58 peer-reviewe [...]

988 10744

Open Access Review

Updates in Liver Transplantation for Alcohol-Related Liver Disease

Michael J Eiswerth and

Joel Wedd

Received: 30 November 2024; Published: 17 April 2025; doi: 10.21926/obm.transplant.2502247

Abstract

The prevalence of alcohol use disorder (AUD) and alcohol-related liver disease (ALD) has increased in the last two decades. ALD is currently the most common indication for both waitlist additions and liver transplant (LT) in the United States, including alcohol-associated cirrhosis, alcohol-associat [...]

1115 8896

Open Access Case Report

When Immunity Falls Short: Meningoencephalitis Despite Vaccination - A Case Report

Sara Evans ,

Ariba Moin and

Ashwini Arjuna

Received: 13 June 2024; Published: 09 April 2025; doi: 10.21926/obm.transplant.2502246

Abstract

Varicella-zoster virus (VZV) significantly impacts the central and peripheral nervous systems, particularly in immunocompromised individuals. This case report details a rare presentation of VZV meningoencephalitis in a 42-year-old woman with interstitial lung disease and connective tissue disease un [...]

789 4051

Open Access Review

Poly ε-Caprolactone Scaffolds: Advancements in Bone Regeneration and Grafting

Ramin Raoufinia ,

Saleh Hashemi ,

Kimia Arabi ,

Karim Naghipoor ,

Farhad Fakoor and

Ehsan Saburi

Received: 20 October 2024; Published: 02 April 2025; doi: 10.21926/obm.transplant.2502245

Abstract

In orthopedics and oncology, benign and malignant bone lesions pose significant clinical challenges. Malignant tumors, like osteosarcomas and multiple myeloma, pose substantial health dangers and can spread common and mostly non-life-threatening benign lesions, including non-sizing fibromas and unic [...]

1045 8589

Open Access Review

Cytomegalovirus Management in Solid Organ Transplant Recipients

Ibrahim Nahit Sendur ,

Büsra Köksoy and

Yasemin H. Balaban

Received: 11 November 2024; Published: 01 April 2025; doi: 10.21926/obm.transplant.2502244

Abstract

Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality in solid organ transplant (SOT) recipients. Despite advancements in prophylaxis and antiviral therapy, CMV continues to pose clinical challenges in transplant medicine. This review provides a comprehensive overview of CMV, [...]

1389 15078

Open Access Case Report

Pregnancy-Associated Spontaneous Coronary Artery Dissection: Anesthetic Considerations

Alan M Iwahashi ,

Samantha H Garvanovic ,

Uoo R Kim and

Melissa D McCabe

Received: 29 August 2024; Published: 20 March 2025; doi: 10.21926/obm.transplant.2501243

Abstract

Spontaneous coronary artery dissection (SCAD) accounts for one-third of all peripartum myocardial infarction. Peripartum SCAD is associated with increased severity. We surmise that altered maternal cardiac physiology increases susceptibility to SCAD and warrants consideration when managing cardiac i [...]

948 4973

Open Access Review

Review of Heterotopic Heart Transplantation Models in Rats

Koji Kawago ,

John A Farag ,

Yujiro Kawai ,

Umayr Syed ,

Eric Pfrender ,

Satoshi Miyairi and

Yasuhiro Shudo

Received: 21 October 2024; Published: 14 March 2025; doi: 10.21926/obm.transplant.2501242

Abstract

Heterotopic heart transplantation (HHT) in rats is a valuable tool for cardiac transplantation research. While abdominal HHT has been established in rats for nearly 90 years, novel approaches involving cervical and femoral techniques have also been explored. The abdominal HHT model, despite its long [...]

1104 5208

Open Access Review

Allogeneic Stem Cell Transplantation: Current Status and Future Directions

Ajay Kumar and

Juveriya Israr

Received: 03 August 2024; Published: 12 March 2025; doi: 10.21926/obm.transplant.2501241

Abstract

Allogeneic stem cell transplantation (allo-SCT) improves the treatment of hematopoietic cancer and non-malignant disease. In this case, stem cells from a genetically similar but not identical donor may stimulate immune-mediated tumor cell destruction. Allogeneic stem cell transplantation, or allo-SC [...]

1220 10411

Open Access Original Research

Design and Simulation of Computational Models of Hybrid Scaffolds Representative of Subchondral Bone and Hyaline Cartilage

Jessica Palacios ,

Odin Ramírez-Fernández and

Esmeralda Zuñiga-Aguilar

Received: 22 August 2024; Published: 07 March 2025; doi: 10.21926/obm.transplant.2501240

Abstract

Tissue engineering offers alternatives when it comes to health problems such as trauma or pathologies. One of them is the scaffolds, which provide a favorable architecture, mechanics, and biocompatibility for the fixation of cells. Therefore, the following research aims to design and simulate scaffo [...]

681 4118

Open Access Review

The Role of Pulmonary Rehabilitation in Lung Transplantation for Cystic Fibrosis

Esra Pehlivan

Received: 11 December 2024; Published: 03 March 2025; doi: 10.21926/obm.transplant.2501239

Abstract

Cystic fibrosis (CF) is a genetic disorder that significantly impacts respiratory function, leading to progressive lung damage and ultimately respiratory failure. Lung transplantation (LTx) is a critical intervention for CF patients with end-stage lung disease, offering improved survival and quality [...]

1160 7270

Open Access Original Research

Management of Atrial Fibrillation after Kidney Transplant: Do We Need a New Metric?

Maria V. Fonseca Bauza ,

Aimee H. Dubin ,

Chris B. Agala ,

Alexander H. Toledo ,

Kristen R. Szempruch ,

David A. Gerber and

Pablo Serrano Rodriguez

Received: 06 December 2024; Published: 27 February 2025; doi: 10.21926/obm.transplant.2501238

Abstract

To evaluate the bleeding risk associated with anticoagulation (AC) in kidney transplant patients with post-operative atrial fibrillation (AF). We conducted a retrospective analysis of all adult kidney transplant recipients performed from October 2012 to February 2019 at our institution, the Universi [...]

663 4576

Open Access Original Research

Integrating Telemonitoring in COPD Exacerbations Care: A Multinational Study Using the Alsayed System for Applied Medical-Care Improvement (ASAMI) Database

Ahmad R. Alsayed and

Yazan Alsayed

Received: 26 August 2024; Published: 25 February 2025; doi: 10.21926/obm.transplant.2501237

Abstract

This study was designed to investigate the ability of telemonitoring involving a secure electronic database called “Alsayed System for Applied Medical-Care Improvement” (ASAMI) to detect at least 95% of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). This prospective observati [...]

797 5025

Open Access Review

Introduction to COVID-19 Vaccines and Kidney Transplant Recipient

Juveriya Israr and

Ajay Kumar

Received: 03 August 2024; Published: 24 February 2025; doi: 10.21926/obm.transplant.2501236

Abstract

COVID-19 has presented considerable health hazards, particularly for immunocompromised persons, such as kidney transplant recipients. This population experiences increased susceptibility due to the immunosuppressive treatments necessary to avert organ rejection, potentially resulting in a diminished [...]

725 6018

Open Access Review

Maribavir for Management of Cytomegalovirus in Lung Transplant Recipients: A Case Series and Literature Review

Jade M Kozuch ,

Kamyar Afshar and

Ashley Feist

Received: 15 November 2024; Published: 20 February 2025; doi: 10.21926/obm.transplant.2501235

Abstract

Lung transplant recipients represent a high-risk group for cytomegalovirus (CMV) infection and disease, even among solid organ transplant (SOT) recipients, due to multiple factors. Additionally, CMV has significant consequences in this group including pneumonitis, acute rejection, and chronic lung a [...]

1242 10219

Open Access Review

Acute Liver Failure Due to Assumed Drug Induced Liver Injury but Lack of Any Validated Causality Algorithm: Evidence by 36 Cohort Reports with 21,709 Cases

Rolf Teschke and

Axel Eickhoff

Received: 08 January 2025; Published: 14 February 2025; doi: 10.21926/obm.transplant.2501234

Abstract

Liver transplantation (LT) can be the only option for patients with acute liver failure (ALF) where medical approaches are ineffective. Causes of ALF are multiple and commonly easily detectable, but uncertainty remained on the role of drug-induced liver injury (DILI) within the published ALF cohorts [...]

1085 5886

Open Access Research Article

Embracing Time: The (Dis)Comfort of Life After Allogeneic Stem Cell Transplants

Lúcia Bacalhau and

Patrícia Pontífice-Sousa

Received: 19 September 2024; Published: 06 February 2025; doi: 10.21926/obm.transplant.2501233

Abstract

Allogeneic Stem Cells Transplantation (ASCT) and, consequently, the chronicity associated with this life event has a growing prevalence and a significant impact on the life and daily life of each person who experiences it. The growing number of ASCT survivors highlights the need to reflect on the un [...]

593 3418

Open Access Short Review

Versatility of the Axillary Intra-Aortic Balloon Pump in Adult Cardiac Surgery

Marcus Taylor ,

Zakariya Mouyer ,

Eltigani Abdelaal and

Nnamdi Nwaejike

Received: 23 July 2024; Published: 22 January 2025; doi: 10.21926/obm.transplant.2501232

Abstract

The axillary intra-aortic balloon pump (ax-IABP) has been proposed as an alternative to the femoral IABP, particularly for patients with comorbidities rendering them unsuitable for fem-IABP insertion. Patient mobilisation with the ax-IABP in situ is deemed an additional potential benefit. We reviewe [...]

671 3781

Open Access Original Research

Efficiency of Pre-Expanded Anterior Supraclavicular Artery Pedicled Skin Flaps: A Meta-Analysis Study

Ziyad Alharbi

Received: 27 March 2024; Published: 13 January 2025; doi: 10.21926/obm.transplant.2501231

Abstract

The supraclavicular artery flap presents a promising solution for facial reconstruction challenges since 1997, surpassing limitations of traditional methods like the deltopectoral flap. Its extended pedicle and thin, pliable epidermis offer reliable outcomes with minimal donor site morbidity, making [...]

650 3708

Open Access Original Research

Leukocytosis is Common Following Pediatric Liver Transplant for Biliary Atresia but Should be Interpreted with Caution

A. Isabella Shanker ,

Lauren T. Maloney and

Julia M. Boster

Received: 23 September 2024; Published: 10 January 2025; doi: 10.21926/obm.transplant.2501230

Abstract

Infection is a leading cause of short-term morbidity and mortality in pediatric patients after liver transplant (LT). Diagnosing infection in this population can be challenging, requiring consideration of laboratory results and clinical context. The prevalence and significance of post-operative leuk [...]

836 4999

Open Access Editorial

Acknowledgement to Reviewers of OBM Transplantation in 2024

OBM Transplantation Editorial Office

Received: 02 January 2025; Published: 02 January 2025; doi: 10.21926/obm.transplant.2501229

Abstract

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to rec [...]

494 2574

Open Access Original Research

Tacrolimus Therapeutic Response, Pharmacokinetics and Adherence in Liver Transplant Recipients

Mouna Daldoul ,

Rim Charfi ,

Khouloud Ferchichi ,

Mouna Ben Sassi ,

Syrine Ben Hammamia ,

Fatma Medhioub ,

Emna Gaies ,

Rym Enneifer ,

Hanene Eljebari ,

Anis Klouz ,

Riadh Daghfous and

Sameh Trabelsi

Received: 20 August 2024; Published: 13 December 2024; doi: 10.21926/obm.transplant.2404228

Abstract

A high intra and interindividual pharmacokinetics variability characterize Tacrolimus. Data regarding factors influencing its pharmacokinetics and pharmacodynamics in liver transplantation are limited. This study aimed to assess tacrolimus therapeutic response, pharmacokinetics and adherence in live [...]

1051 9685

Open Access Original Research

A Phase I/II Randomized Trial of Higher Dose mRNA-1273 Boosters in Lung Transplant Recipients

Michael Y. Shino ,

Francisco Javier Ibarrondo ,

Jesse L. Clark ,

Adreanne Rivera ,

Marlene Florian ,

Allison Ramsey ,

Ariss Derhovanessian ,

Rajan Saggar ,

Olawale O. Amubieya ,

Grant Turner ,

Joanna M. Schaenman ,

Pryce T. Gaynor ,

Omer E. Beaird ,

Ashrit Multani ,

Reshma M. Biniwale ,

Murray H. Kwon ,

Christos J. Petropoulos ,

Yolanda Lie ,

Terri Wrin ,

Amparo L. Figueroa ,

Brett Leav ,

Zelalem Endale ,

Kate Anteyi ,

Jacqueline M. Miller ,

Abbas Ardehali ,

David M. Sayah ,

David Elashoff ,

John A. Belperio ,

Otto O. Yang and

S. Sam Weigt

Received: 16 August 2024; Published: 20 November 2024; doi: 10.21926/obm.transplant.2404227

Abstract

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher- [...]

851 4079

Open Access Research Article

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

Sabrine Mekni ,

Lamia Torjemane ,

Malek Khayati ,

Dorra Belloumi ,

Rimmel Yosra Kanoun ,

Insaf Ben Yaiche ,

Rihab Ouerghi ,

Ines Turki ,

Saloua Ladeb ,

Tarek Ben Othman and

Nour Ben Abdeljelil

Received: 29 June 2024; Published: 11 November 2024; doi: 10.21926/obm.transplant.2404226

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to [...]

999 5764

Open Access Case Report

Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of Acne

Elga J. Vargas ,

Julio C. Martinez and

Lina A. Gomez

Received: 26 April 2024; Published: 03 October 2024; doi: 10.21926/obm.transplant.2404225

Abstract

Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In [...]

852 7587

Open Access Review

Current and Future Applications of Machine Perfusion and Other Dynamic Preservation Strategies in Liver Transplantation

Yue Qiu ,

Yinqian Kang ,

Hao Liu and

Ibtesam Hilmi

Received: 12 May 2024; Published: 30 August 2024; doi: 10.21926/obm.transplant.2403224

Abstract

Machine perfusion (MP) techniques, which simulate physiological conditions to allow for the assessment and preservation of organ viability, are currently applied in various solid organ transplantation fields. Owing to the growing demand for liver transplants and [...]

909 12475

Open Access Review

Platelets as Regenerative Cells, Hundreds of Opportunities in Sight

Elga Johanna Vargas ,

Ana Luisa Muñoz and

Lina Andrea Gómez

Received: 21 May 2024; Published: 13 August 2024; doi: 10.21926/obm.transplant.2403223

Abstract

Platelets were the last to be discovered of the three formed blood elements. Several scientists have been interested in them, recognizing them as cells other than leukocytes and erythrocytes. Its job in hemostasis and thrombosis is currently known. Platelets contain growth factors and secrete cytoki [...]

686 4456

Open Access Review

Machine Perfusion of Donor Hearts – The Recovery and Transplantation of Previously Unrecoverable Hearts

Sanjay Dutta ,

Jeanette E. Villanueva ,

Yashutosh Joshi ,

Ling Gao ,

Paul Jansz and

Peter S. Macdonald

Received: 02 April 2024; Published: 05 August 2024; doi: 10.21926/obm.transplant.2403222

Abstract

Heart transplantation remains the gold standard treatment for end-stage heart failure. With an increasing population and improving medical therapy there is an increasing number of patients who would benefit from heart transplantation but are unable to receive one due to a shortage of sui [...]

1129 6319

Open Access Review

BK Virus-Associated Nephropathy in Adult Patients Post Kidney Transplantation: What Progress in 30 Years of History?

Yassamine Bentata

Received: 24 January 2024; Published: 25 July 2024; doi: 10.21926/obm.transplant.2403221

Abstract

Completely unknown before the 90s and exceptional up to the 2000s, BK virus nephropathy (BKvN), usually known as polyomavirus-associated nephropathy, has emerged as a significant and severe viral complication in kidney transplantation (KT). More than twenty years after Gardner's discovery of BKv in [...]

954 12513

Open Access Research Article

Impact of Intravenous Immunoglobulin Replacement Therapy on Hypogammaglobulinemia and Infection in Lung Transplant Recipients

Van Anh Vu ,

Joelle Nelson ,

Helen Sweiss ,

Reed Hall ,

Holly Keyt and

Elisabeth Kincaide

Received: 29 January 2024; Published: 03 July 2024; doi: 10.21926/obm.transplant.2403220

Abstract

Secondary hypogammaglobulinemia (HGG) from immunosuppression therapy in lung transplant recipients has been associated with increased mortality, morbidity and higher risk of infection. Intravenous immunoglobulin (IVIG) for the treatment of HGG post-lung transplant is not well studied with conflictin [...]

762 6407

Open Access Original Research

Detection of Activated Pepsin in Bronchoalveolar Lavage and Acute Cellular Rejection in Lung Transplant Recipients

Andrés R. Latorre-Rodríguez ,

Devika Sindu ,

Sumeet K. Mittal and

Ashwini Arjuna

Received: 23 February 2024; Published: 21 June 2024; doi: 10.21926/obm.transplant.2402219

Abstract

Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii) as [...]

1058 5764

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