OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Infectious Complications in Hematopoietic Stem Cell Transplantation
Submission Deadline: November 30, 2019 (Open) Submit Now
Dora Ho, MD, PhD
Clinical Associate Professor, Clinical Chief, Division and Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University, USA
Research Interests: Infectious Diseases, Immunocompromised Host, infection complications in immunocompromised patients, such as those with bone marrow transplant, solid organ transplant, cancers and other forms of immunodeficiency
About the Topic
Hematopoietic cell transplantation (HCT) is a life-saving procedure for many patients, but depending of the specific types of transplant and the protocols employed, transplant recipients may face various peri- or post-transplant complications that can cause significant morbidity and mortality. In particular, HCT recipients are at substantial risk for infections, from those of nosocomial nature that affect hospitalized patients in general, to those rare opportunistic infections that manifest only in profoundly immunocompromised hosts. Caring for HCT patients demands much expertise and dedication. Especially, Infectious Diseases physicians that specialize in HCT need to familiarize themselves with the basic principles of HCT and understand the functioning of the immune system at different time of the HCT process. They also need to be aware of the HCT recipients’ risk factors to various types of infection and be knowledgeable of a myriad of clinical syndromes associated with HCT, from both infectious and noninfectious etiologies.
In this particular issue of the journal, authors are invited to share their experiences and challenges regarding infectious complications in HCT, in the form of editorials, case reports, clinical research articles and reviews and so on.
by Muayad Alali , Michael Z David , Sandra A. Ham , LA Danziger-Isakov , Allison H. Bartlett , Lindsay Petty and Jennifer Pisano
Received: 27 November 2019; Published: 21 February 2020; doi: 10.21926/obm.transplant.2001102
Most studies of children with prolonged fever and neutropenia (PFN) have focused on invasive fungal disease (IFD) as the etiology of fever and not on other causes. Data are lacking regarding risk factors and adverse outcomes in pediatric cancer patients with PFN compared with those whose fevers resolve more rapidly. Retrospective medical recor [...]
Hematopoietic Stem Cell Transplantation in Refractory Celiac Disease: An Overview with Focus on Infectious Complications
Received: 16 December 2019; Published: 18 February 2020; doi: 10.21926/obm.transplant.2001101
Refractory celiac disease (RCD) is a rare condition in which a known celiac patient, usually an adult, suffers from persistence or recurrence of gluten-related symptomatology, laboratory abnormalities, and inflammatory enteropathy despite following an optimal dietary therapy with gluten-free diet (GFD). Arbitrarily, a duration of at least [...]
Utility of Fungal Cell Markers in Pediatric Bone Marrow Transplant Recipients for Screening and Diagnosis of Invasive Fungal Infections
Received: 12 November 2019; Published: 04 February 2020; doi: 10.21926/obm.transplant.2001098
Invasive fungal disease (IFD) is a significant contributor to morbidity and mortality in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Early detection and timely initiation of antifungal therapy is important for improved outcome, but diagnosis remains difficult, especially when relying on conventional microbiolo [...]
Received: 25 June 2019; Published: 26 August 2019; doi: 10.21926/obm.transplant.1903081
Hematopoietic stem cell transplant (HSCT) recipients are at an increased risk of bacterial, viral, fungal and parasitic infections. Past exposures to infections, the degree of immunosuppression, prolonged neutropenia and presence of graft versus host disease (GVHD) are some of the factors which make HSCT recipients more susceptible to infectio [...]
Never Say Never: Unexpected Pulmonary Pathogens Found on Autopsy in Hematopoietic Cell Transplantation Recipients
Received: 03 June 2019; Published: 29 July 2019; doi: 10.21926/obm.transplant.1903076
Hematopoietic cell transplantation is frequently complicated by infectious disease-related complications, especially pneumonia. Candida and enterococci are often overlooked as pulmonary pathogens with some clinicians firmly believing that these organisms never cause pneumonia. Here, we present a series of five cases of Candida pneumonia and [...]
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