OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Complications and Management of Kidney Transplantation: Focus on Infection
Submission Deadline: October 31, 2022 (Open) Submit Now
Deborah B. Adey, MD, Professor of Medicine
University of California, San Francisco, San Francisco, United States
Research Interests: Kidney Transplantation; Infections in kidney transplantation; Long term management kidney transplantation
About This Topic
Management of solid organ transplant recipients is always an exercise in finding the right balance of immunosuppression, which can pose a significant challenge. Under immunosuppression risks organ rejection while over immunosuppression puts the recipient at risk for infection or malignancy. The risk for infectious complications post-kidney transplantation is dependent upon several factors including organ donor exposures (living or deceased), recipient exposures, surgical issues, geography, timing since transplant, and patient immunosuppression. Viral and fungal infections are common amongst transplant recipients due to the nature of T-cell focused immunosuppression in organ transplantation. However, a broad net of suspicion should be cast as transplant recipients are likely to have atypical presentations with atypical organisms. Management of the transplant recipient with infection can be complicated and needs to take into consideration the nature of the immunosuppression, the overall risks of immunosuppression reduction, drug interactions with immunosuppression agents, and duration of therapy. Successful management of infections in kidney transplant recipients requires a multidisciplinary approach to diagnosis and management.
by Uttayan Chakrabarti , Manish Chaturvedy , Nitin Kumar Bajpai , Jitendra Goswami , Rajesh Kumar Garsa and Rajesh Jhorawat
Received: 10 April 2023; Published: 14 July 2023; doi: 10.21926/obm.transplant.2303192
BK virus (BKV) is a common opportunistic pathogen in kidney transplant recipients and one of the most challenging causes of allograft dysfunction and loss. Although over-immunosuppression remains the primary risk factor for BKV infection after transplantation, male gender, older recipient age, prior rejecti [...]
Received: 28 October 2022; Published: 19 April 2023; doi: 10.21926/obm.transplant.2302182
Cryptococcosis is a common invasive fungal infection in solid organ transplant recipients (SOTR) that can be challenging to manage. We discuss a case of disseminated cryptococcosis in a transplant recipient. A 26-year-old woman with a history of ESRD from C1q nephropathy, living-related kidney transplant in early 2012, and allograft nephrectom [...]
Hepatitis B Reactivation in HBsAg Negative Renal Transplant Patients with Evidence of Previous HBV Infection: A Not Neglectable Occurrence
by Ana Paula Leopercio , Christini Emori , Elisabete Calore Neiva , Ana Lucia Silva Souza , Ana Cristina Amaral , Gustavo Almeida Vieira , Raimundo Araujo Gama , Jose Osmar Medina-Pestana and Maria Lúcia Ferraz
Received: 22 June 2022; Published: 26 October 2022; doi: 10.21926/obm.transplant.2204168
Hepatitis B virus (HBV) infection is frequent among patients with chronic kidney disease (CKD). HBV reactivation after kidney transplant (KT) is more common in patients with HBsAg+; however, it can also occur in previously infected individuals, particularly those with HBsAg negative and total antiHBc positive (HBsAg-/antiHBcT+ [...]
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