Open Access Review

Novel Therapies for the Treatment of Antibody Mediated Rejection in Solid Organ Transplantation: A Systematic Review

Received: 29 October 2025;  Published: 24 February 2026;  doi: 10.21926/obm.transplant.2601267

Abstract

Antibody mediated rejection (AMR) is a considerable cause of late allograft failure in solid organ transplantation. Conventional approaches, using plasmapheresis, intravenous immunoglobulin, rituximab, bortezomib, and eculizumab have been unsuccessful in improving graft survival. This review aims to assess emerging therapies for AMR treatment [...]