Astrocyte-Neuron Interactions in the Neuroinflammatory Cascade of Traumatic Brain Injury
Abstract
Traumatic brain injury (TBI) is a significant public health concern, leading to substantial morbidity and mortality. While the primary injury is mechanical, the subsequent neuroinflammatory cascade plays a critical role in secondary injury and long-term neurological deficits. Astrocytes, the most abundant glial cells in the brain, play a key role in this cascade, interacting with neurons in a complex interplay that can both protect and exacerbate neuronal damage. This paper aims to provide a com [...]