by Ebru Sayilgan

Received: 14 August 2025;  Published: 24 September 2025;  doi: 10.21926/obm.neurobiol.2503302

Motor deficits induced by neurological disorders impose a severe impact on activities of daily life. Conventional rehabilitation practices necessitate ongoing clinical supervision, which is costly and inaccessible. EEG-based brain-computer interface (BCI) systems offer a viable solution by facilitating neurorehabilitation through the direct interpretation of brain signals. Nonetheless, current systems are confronted with issues of real-time control, portability, and classification precision. The [...]

by Hardiyati Hardiyati  , Iyus Yosep  , Meita Dhamayanti  , Veranita Pandia  and Rohman Hikmat

Received: 17 May 2025;  Published: 15 September 2025;  doi: 10.21926/obm.neurobiol.2503301

This article aims to evaluate the impact of mindfulness training on Mr. A, a 17-year-old adolescent with schizophrenia experiencing social isolation and severe anxiety. The subject, Mr. A, is a 17-year-old male who presented with significant anxiety symptoms, including excessive worry, restlessness, difficulty concentrating, irritability, heart palpitations, rapid breathing, and sleep disturbances. These symptoms were accompanied by behaviors of social withdrawal, emotional detachment, and reluc [...]

by Nahid Hoseininezhad  , Roghieh Nooripour  , Davod Fathi  , Parviz Fadakar Gabalou  and Seyedeh Monavar Yazdi

Received: 11 February 2025;  Published: 01 September 2025;  doi: 10.21926/obm.neurobiol.2503300

Interpersonal mindfulness, involving present-moment awareness and acceptance during social interactions, is crucial for emotional regulation and adaptive interpersonal functioning. This study examined the psychometric properties of the Persian version of the Interpersonal Mindfulness Scale (IMS), a 27-item instrument with four subscales: presence, awareness of self and others, nonjudgmental acceptance, and nonreactivity. The cross-sectional sample included 15- to 17-year-old Iranian adolescents [...]

by Sergey Lytaev  and Ksenia Belskaya

Received: 18 December 2024;  Published: 29 August 2025;  doi: 10.21926/obm.neurobiol.2503299

Consciousness is an integrative process that combines several executive functions, as well as the analytical and synthetic activity of the brain. In some psychopathological conditions, in particular, in schizophrenia, low-information "borderline" disorders of the executive functions and consciousness are often formed at the onset. The present study was aimed at assessing the integration of the bran alpha regulatory system and the modulation of consciousness based on the data of recordi [...]

by Abdulmalik Ahmad Lawan  , Hauwa Zakariyya Abdullahi  , Abdullahi Yunusa Abdullahi  and Sadiya Tahir

Received: 16 January 2025;  Published: 15 August 2025;  doi: 10.21926/obm.neurobiol.2503298

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with significant heterogeneity in symptoms and comorbid conditions. Studies have shown the value of early and accurate diagnosis in mitigating the associated social and behavioral challenges. Recently, studies have demonstrated the potential of machine learning (ML) models in identifying ASD patterns from neuroimaging, genetic, and behavioral data. However, the limited interpretability of these models poses a barrier to t [...]

by Ami Rokach

Received: 08 May 2025;  Published: 14 August 2025;  doi: 10.21926/obm.neurobiol.2503297

Loneliness, social isolation, aloneness, and solitude may be used interchangeably by some who may miss the difference between them. Loneliness is the experience of being alone, or perceiving that one is alone and unimportant to others. Solitude is being geographically isolated out of one’s choice. Loneliness is not a feeling, but a multidimensional construct which is expressed cognitively, behaviorally and affectively. solitude is also reviewed and a clear distinction between loneliness and soli [...]

by Samhani Ismail  , Muhammad Hakimi Mohd Nashron  , Mohd Hanifah Jusoh  and Abdul Nawfar Sadagatullah

Received: 26 February 2025;  Published: 05 August 2025;  doi: 10.21926/obm.neurobiol.2503296

Chronic pain involves complex cortical and subcortical changes, suggesting that brain electrical activity may be a potential biomarker for nociceptive processing. Pain leaves its signature in the brain's oscillatory patterns, yet limited studies have explored the neurophysiological alterations associated with chronic pain. This review examines the pain detection method currently used in clinical settings, the potential of neurophysiological features to become brain oscillatory brain biomarkers, [...]

by Michael Okoronkwo  , Aaron Mack  , Keyana Varnado  , Michael Alfred  , Kevin Hardy  , Amarachi Osuji  , Percy Takyi  , Gabriel Onor  , Oluwatomi Akingbola  and Rahn Bailey

Received: 17 April 2024;  Published: 04 August 2025;  doi: 10.21926/obm.neurobiol.2503295

Pandemic lockdown orders resulted in closures to critical community networks. One such infrastructure was community recreation centers/parks. This infrastructure serves a critical role in building psychosocial wellness for youth. Socioeconomic minority youth face baseline disparity in center/park distribution and services. Youth recreation activity declined 50% as result of lockdown orders with corresponding decline in youth mental health status. Despite overall youth activity decline, White and [...]

by Navid Khaleghimoghaddam  and Sara Arzhangi

Received: 11 April 2025;  Published: 31 July 2025;  doi: 10.21926/obm.neurobiol.2503294

The acoustic design of indoor environments encompassing spatial configuration, material properties, and sound absorption significantly influences auditory perception and psychological well-being. This study examines the interaction between architectural acoustics, musical stimuli, and neural responses within a controlled therapeutic context, focusing on their effects on stress reduction and relaxation. Electroencephalography (EEG) was utilized to measure brain activity in 24 participants exposed [...]

by Alvard Minasyan  and Naira Sahakyan

Received: 20 May 2025;  Published: 30 July 2025;  doi: 10.21926/obm.neurobiol.2503293

Microglial activation and the associated oxidative or inflammatory responses play a crucial role in the development of neurodegenerative diseases. In this study, we evaluated the antioxidant, cytotoxic, and anti-inflammatory properties of Teucrium polium (TP) ethanolic extract in murine BV-2 microglial cells, including wild-type (Wt) and peroxisomal β-oxidation-deficient Acox1^-/-

by Robert Medina  , Akanksha Dave  , Candice Keogh  , Jordan Bartfield  , Franco Estenssoro  , Melissa Fraga  and Brandon Lucke-Wold

Received: 28 February 2025;  Published: 21 July 2025;  doi: 10.21926/obm.neurobiol.2503292

This review examines a multimodal approach that integrates advanced neuroimaging, biofluid biomarkers, and innovative rehabilitation strategies for the optimized diagnosis and recovery of traumatic brain injury (TBI). TBI remains a critical public health challenge due to its high incidence and diverse, long-lasting morbidities. Conventional diagnostic methods often lack the sensitivity to detect subtle injuries, and current prognostic models are limited by the heterogeneity of TBI. Emerging neur [...]

by Mega Obukohwo Oyovwi  , Victor Oghenekparobo Emojevwe  , Benneth Ben-Azu  and Ejayeta Jeroh

Received: 31 March 2025;  Published: 09 July 2025;  doi: 10.21926/obm.neurobiol.2503291

Traumatic brain injury (TBI) is a significant public health concern, leading to substantial morbidity and mortality. While the primary injury is mechanical, the subsequent neuroinflammatory cascade plays a critical role in secondary injury and long-term neurological deficits. Astrocytes, the most abundant glial cells in the brain, play a key role in this cascade, interacting with neurons in a complex interplay that can both protect and exacerbate neuronal damage. This paper aims to provide a com [...]

by Igor Val Danilov  , Dace Medne  and Sandra Mihailova

Received: 09 February 2025;  Published: 03 July 2025;  doi: 10.21926/obm.neurobiol.2503290

Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed elec [...]