OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
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Molecular Determinants of Fertility in the Female
Submission Deadline: January 31, 2023 (Open) Submit Now
Rita Payan-Carreira, PhD, Professor
University of Évora, Evora, Portugal
Research Interests: theriogenology; molecular biology; fertility and infertility; embryo-maternal interaction; clinical diagnosis
About This Topic
Factors determining female fertility are not limited to organ abnormalities or defects, common reproductive diseases, and aging. Still, these causes do not cover all the reasons for compromised fertility. Environmental and lifestyle factors, as well as some organic dysfunction (endocrine, immune), and idiopathic causes, challenge the clinician to explain infertility. Understanding the main determinants of female fertility will drive a more profound knowledge of the mechanism underlying the normal reproductive function. It will also allow improving strategies to mitigate infertility issues or restore fertility.
Multiple cellular events and a network of molecular pathways are involved in reproductive homeostasis, guaranteeing an adequate performance and producing a healthy offspring. However, infertility is a major emerging issue in both humans and animals. Some molecules have been pointed to be at the origin of unspecific idiopathic infertility, like the oxidative stress-related molecules or the environmental born endocrine disrupters. Besides, genetic mutations have also been involved in particular infertility cases, whether directly impairing the embryo survival or by inducing changes in the normal fallopian or uterine microenvironment that compromise gametes and early embryo survival at implantation.
Proteomic, genetic, and other advanced molecular techniques brought new information, highlighting the importance of particular pathways and molecules in the female reproductive fitness and fertility. In animals, these fertility-related pathways may present species specificities that are issued from selective pressures. These are also important in animal species, considering that wild populations often suffer from genetic bottleneck compromising the reproductive function.
Because of the broad interest in the characterization of molecular determinants of female reproductive function, we would like to invite researchers to contribute with their results or reviews to this Special Issue, whose scope tackles female fertility's molecular determinants.
molecular determinants; female fertility; reproductive fitness; theriogenology; pregnancy success; molecular pathways; infertility
Received: 25 August 2021; Published: 26 April 2022; doi: 10.21926/obm.genet.2202153
In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes [...]
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