Open Access Original Research

Predicting Tumor Mutational Burden in Prostate Cancer Using Deep Learning on Histopathological Images

Received: 11 February 2026;  Published: 07 September 2026;  doi: 10.21926/obm.genet.2603357

Abstract

Tumor mutational burden (TMB) is a critical biomarker associated with the response to immunotherapy in prostate cancer. The heterogeneity of tumors can complicate the prediction of TMB, making reliable detection essential for effective treatment planning. Recent advancements in deep learning (DL) have facilitated the analysis of histopathologi [...]